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Properties of C5a Receptor on Human Macrophages

Autor: Vernon Seow

Macrophages (MP) are important to host defence and inflammation but plasticity in theirgene expression profiles contributes to their functional heterogeneity. C5a is one of the most potentproinflammatory agents generated upon complement activation an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64284c3383c57529badde7faae4084e9
https://doi.org/10.14264/uql.2017.437

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Diet‐induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism

Autor: Junxian Lim, Lindsay Brown, Vernon Seow, David P. Fairlie, Ligong Liu, Mei-Kwan Yau, Jacky Y. Suen, Rink-Jan Lohman, Abishek Iyer

Publikováno v: The FASEB Journal. 27:4757-4767

Excessive uptake of fatty acids and glucose by adipose tissue triggers adipocyte dysfunction and infiltration of immune cells. Altered metabolic homeostasis in adipose tissue promotes insulin resistance, type 2 diabetes, hypertension, and cardiovascu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662b2ec8f642521b8690fcfdd8207a74
https://doi.org/10.1096/fj.13-232702

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Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists

Autor: Vernon Seow, Adam J. Cotterell, Junxian Lim, Weijun Xu, Jacky Y. Suen, David P. Fairlie, Martin J. Stoermer, W. Mei Kok, Rink-Jan Lohman, Mei-Kwan Yau, Matthew J. Sweet, Robert Reid

Publikováno v: Scientific Reports

Drug discovery and translation are normally based on optimizing efficacy by increasing receptor affinity, functional potency, drug-likeness (rule-of-five compliance) and oral bioavailability. Here we demonstrate that residence time of a compound on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576f09ed534eec95e0408e518dc69c39
http://europepmc.org/articles/PMC4837355

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The Stem Region of Premembrane Protein Plays an Important Role in the Virus Surface Protein Rearrangement during Dengue Maturation

Autor: Lukas B. Tanner, Xue Li Guan, Sumarlin Lee, Petra Kukkaro, Yin Hoe Yau, Susana Geifman Shochat, Pei Yong Shi, Vernon Seow, Markus R. Wenk, Guntur Fibriansah, Shee-Mei Lok, Qian Zhang, Goran Biuković, Cornelia Hunke, Pau Ling Chew, Gerhard Grüber

Publikováno v: Journal of Biological Chemistry. 287:40525-40534

Dengue virus surface proteins, envelope (E) and pre-membrane (prM), undergo rearrangement during the maturation process at acidic condition.prM-stem region binds tighter to both E protein and lipid membrane when environment becomes acidic.At acidic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e412600992f6c587ee001806f9c9ec71
https://doi.org/10.1074/jbc.m112.384446

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Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a

Autor: Juliana K. Ariffin, Abishek Iyer, Junxian Lim, Jacky Y. Suen, Daniel M. Hohenhaus, David P. Fairlie, Vernon Seow, Matthew J. Sweet

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 191(8)

Monocytes and macrophages are important innate immune cells equipped with danger-sensing receptors, including complement and Toll-like receptors. Complement protein C5a, acting via C5aR, is shown in this study to differentially modulate LPS-induced i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f0894917e5cb68ec0e7e36c4012007
https://pubmed.ncbi.nlm.nih.gov/24043889

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An mRNA atlas of G protein-coupled receptor expression during primary human monocyte/macrophage differentiation and lipopolysaccharide-mediated activation identifies targetable candidate regulators of inflammation

Autor: David P. Fairlie, Kolja Schaale, Abishek Iyer, Matthew J. Sweet, Daniel M. Hohenhaus, Vernon Seow, Kim-Anh Lê Cao

Publikováno v: Immunobiology. 218(11)

G protein-coupled receptors (GPCRs) are among the most important targets in drug discovery. In this study, we used TaqMan Low Density Arrays to profile the full GPCR repertoire of primary human macrophages differentiated from monocytes using either c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b01df5d0fdcc78f39337f19350374b
https://pubmed.ncbi.nlm.nih.gov/23948647

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C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling

Autor: Abishek Iyer, Jacky Y. Suen, Vernon Seow, Junxian Lim, Robert Reid, Lindsay Brown, David P. Fairlie

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(2)

Mammalian survival depends on metabolizing nutrients, storing energy, and combating infection. Complement activation in blood triggers energy-depleting immune responses to fight infections. Here we identify surprising energy-conserving roles for comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23d4742be8f59f3c32b1f5791b382aa
https://pubmed.ncbi.nlm.nih.gov/23118029

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