Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Vernon K Ward"'
Autor:
Colin Davies, Vernon K Ward
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161582 (2016)
Murine norovirus-1 (MNV-1) is known to subvert host cell division inducing an accumulation of cells in the G0/G1 phase, creating conditions where viral replication is favored. This study identified that NS5 (VPg), is capable of inducing cell cycle ar
Externí odkaz:
https://doaj.org/article/69092bf7984946009778662d98fce6af
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104523 (2014)
Internalization of peptides by antigen presenting cells is crucial for the initiation of the adaptive immune response. Mannosylation has been demonstrated to enhance antigen uptake through mannose receptors, leading to improved immune responses. In t
Externí odkaz:
https://doaj.org/article/c6ab83fe967b4facbd14d1c30ae5b716
Autor:
Morgan R Herod, Omar Salim, Rachel J Skilton, Cynthia A Prince, Vernon K Ward, Paul R Lambden, Ian N Clarke
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90679 (2014)
Investigations into human norovirus infection, replication and pathogenesis, as well as the development of potential antiviral agents, have been restricted by the lack of a cell culture system for human norovirus. To date, the optimal cell culture su
Externí odkaz:
https://doaj.org/article/2bb8d2b4de25413f84d7066b538b8b0e
Autor:
Estelle S Baker, Sylvia R Luckner, Kurt L Krause, Paul R Lambden, Ian N Clarke, Vernon K Ward
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e30534 (2012)
Human noroviruses are highly infectious viruses that cause the majority of acute, non-bacterial epidemic gastroenteritis cases worldwide. The first open reading frame of the norovirus RNA genome encodes for a polyprotein that is cleaved by the viral
Externí odkaz:
https://doaj.org/article/e7718fb8925746c8b5709ef7dc7c375c
Publikováno v:
Viruses, Vol 16, Iss 8, p 1324 (2024)
An intrinsically disordered protein (IDP) or region (IDR) lacks or has little protein structure but still maintains function. This lack of structure creates flexibility and fluidity, allowing multiple protein conformations and potentially transient i
Externí odkaz:
https://doaj.org/article/3fcdaaa5be4340a1a9ba2c38ab605c7c
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Autor:
Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris
Publikováno v:
ACS Medicinal Chemistry Letters. 14:506-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d43179c43e8630cced245bf2621c5f
https://doi.org/10.1021/acsmedchemlett.3c00048
https://doi.org/10.1021/acsmedchemlett.3c00048
Publikováno v:
Expert Review of Vaccines, Vol 17, Iss 9, Pp 833-849 (2018)
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation from laboratory models, to routine clinical administration. While some VLP vaccines thrive and are readily adopted into the vaccination schedule, others
Externí odkaz:
https://doaj.org/article/e251dc1f456242e3bf3c726ef2572a71
Publikováno v:
Viruses, Vol 13, Iss 8, p 1549 (2021)
Nucleotidylylation is a post-transcriptional modification important for replication in the picornavirus supergroup of RNA viruses, including members of the Caliciviridae, Coronaviridae, Picornaviridae and Potyviridae virus families. This modification
Externí odkaz:
https://doaj.org/article/b2720896e7d3458496bff8cca626a06e