Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Vernon K Ward"'
Publikováno v:
Viruses, Vol 16, Iss 8, p 1324 (2024)
An intrinsically disordered protein (IDP) or region (IDR) lacks or has little protein structure but still maintains function. This lack of structure creates flexibility and fluidity, allowing multiple protein conformations and potentially transient i
Externí odkaz:
https://doaj.org/article/3fcdaaa5be4340a1a9ba2c38ab605c7c
Autor:
Alice-Roza Eruera, Alice M. McSweeney, Geena M. McKenzie-Goldsmith, Helen K. Opel-Reading, Simone X. Thomas, Ashley C. Campbell, Louise Stubbing, Andrew Siow, Jonathan G. Hubert, Margaret A. Brimble, Vernon K. Ward, Kurt L. Krause
Publikováno v:
Viruses, Vol 15, Iss 11, p 2202 (2023)
Norovirus is the leading cause of viral gastroenteritis worldwide, and there are no approved vaccines or therapeutic treatments for chronic or severe norovirus infections. The structural characterisation of the norovirus protease and drug development
Externí odkaz:
https://doaj.org/article/86ca3c78c4f045989589594a543e6b57
Autor:
Carmen Mirabelli, Melissa K. Jones, Vivienne L. Young, Abimbola O. Kolawole, Irene Owusu, Mengrou Shan, Basel Abuaita, Holly Turula, Jose G. Trevino, Irina Grigorova, Steven K. Lundy, Costas A. Lyssiotis, Vernon K. Ward, Stephanie M. Karst, Christiane E. Wobus
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Human norovirus (HNoV) is a global health and socioeconomic burden, estimated to infect every individual at least five times during their lifetime. The underlying mechanism for the potential lack of long-term immune protection from HNoV infe
Externí odkaz:
https://doaj.org/article/298a2a3779044a91988f0db58af882d8
Autor:
Kevin J. Sparrow, Rinu Shrestha, James M. Wood, Keith Clinch, Brett L. Hurst, Hong Wang, Brian B. Gowen, Justin G. Julander, E. Bart Tarbet, Alice M. McSweeney, Vernon K. Ward, Gary B. Evans, Lawrence. D. Harris
Publikováno v:
ACS Medicinal Chemistry Letters. 14:506-513
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4d43179c43e8630cced245bf2621c5f
https://doi.org/10.1021/acsmedchemlett.3c00048
https://doi.org/10.1021/acsmedchemlett.3c00048
Publikováno v:
Expert Review of Vaccines, Vol 17, Iss 9, Pp 833-849 (2018)
Introduction: Virus-like particle (VLP) vaccines face significant challenges in their translation from laboratory models, to routine clinical administration. While some VLP vaccines thrive and are readily adopted into the vaccination schedule, others
Externí odkaz:
https://doaj.org/article/e251dc1f456242e3bf3c726ef2572a71
Publikováno v:
Viruses, Vol 13, Iss 8, p 1549 (2021)
Nucleotidylylation is a post-transcriptional modification important for replication in the picornavirus supergroup of RNA viruses, including members of the Caliciviridae, Coronaviridae, Picornaviridae and Potyviridae virus families. This modification
Externí odkaz:
https://doaj.org/article/b2720896e7d3458496bff8cca626a06e
Publikováno v:
Viruses, Vol 13, Iss 7, p 1282 (2021)
The viral protein genome-linked (VPg) of noroviruses is a multi-functional protein that participates in essential roles during the viral replication cycle. Predictive analyses indicate that murine norovirus (MNV) VPg contains a disordered N-terminal
Externí odkaz:
https://doaj.org/article/ed86c58766404d709d9a4398cdeedc6f
Autor:
Braeden Donaldson, Farah Al-Barwani, Simon J. Pelham, Katie Young, Vernon K. Ward, Sarah L. Young
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-13 (2017)
Abstract Background Colorectal cancer is responsible for almost 700,000 deaths annually worldwide. Therapeutic vaccination is a promising alternative to conventional treatment for colorectal cancer, using vaccines to induce targeted immune responses
Externí odkaz:
https://doaj.org/article/cdf421eccad84ac082a2cee418327f0d
Autor:
Katrin Kramer, Farah Al-Barwani, Margaret A. Baird, Vivienne L. Young, David S. Larsen, Vernon K. Ward, Sarah L. Young
Publikováno v:
Journal of Immunology Research, Vol 2019 (2019)
Virus-like particles (VLP) from the rabbit haemorrhagic disease virus (RHDV) can deliver tumour antigens to induce anticancer immune responses. In this study, we explored how RHDV VLP can be functionalised to enhance the immune response by increasing
Externí odkaz:
https://doaj.org/article/0882ebfbf55a4ce38ae4777e914b9228
Autor:
Katrin Campbell, Vivienne L. Young, Braeden C. Donaldson, Matthew J. Woodall, Nicholas J. Shields, Greg F. Walker, Vernon K. Ward, Sarah L. Young
Publikováno v:
Vaccines, Vol 9, Iss 5, p 463 (2021)
Breast cancer (BC) is the most frequently diagnosed cancer in women, with many patients experiencing recurrence following treatment. Antigens delivered on virus-like particles (VLPs) induce a targeted immune response and here we investigated whether
Externí odkaz:
https://doaj.org/article/c401da3c02d24e7d923fc6c7cf85d928