Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Vernon E. Lawson"'
Autor:
Leila Peraro, Sigrid Carle, Xiaoyu Zang, Heli K. Shah, Ryan T. Davison, Travis R. Blum, David J. Slade, Deepak Vallabhaneni, Caitlyn E. Fennell, Kathryn E. Cole, Matthew R. Burnett, Justin S. Miller, Deirdre M. Wholly, Kathryn M. Ingalls, Jacob T. Sivak, Vernon E. Lawson, Elissa A. Fink, Stephanie L. Cramer, Chelsea T. Herr
Publikováno v:
The Journal of Organic Chemistry. 85:8253-8260
We describe the synthesis of Xyzidepsin, a depsipeptidic analogue of HDAC inhibitor Romidepsin (FK228), using a solid-phase strategy. Our latent thioester solid-phase linker was synthesized in 92% yield (three steps). Chemoselective conditions unmask
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d336d3c2d41912dc2b9df760e904381
https://doi.org/10.1021/acs.joc.0c00854
https://doi.org/10.1021/acs.joc.0c00854
Autor:
Gregory B. Shelkey, Grace E. Hutton, Wade S. Perkins, Vernon E. Lawson, Ryan T. Davison, Justin S. Miller
Publikováno v:
Journal of Peptide Science. 27
Hydrophobic latent C-terminal thioesters were converted into thioesters, and were also coupled with cysteine in one-pot reactions, using conditions generally compatible with hydrophobic materials. The reaction conditions (ethanethiol and triethylamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3f347fa90664828611edc0c16c8bdc
https://doi.org/10.1002/psc.3358
https://doi.org/10.1002/psc.3358