Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Vernon E, Walker"'
Autor:
Dale M. Walker, Tsvetelina I. Lazarova, Steven W. Riesinger, Miriam C. Poirier, Terri Messier, Brian Cunniff, Vernon E. Walker
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
The lack of anticancer agents that overcome innate/acquired drug resistance is the single biggest barrier to achieving a durable complete response to cancer therapy. To address this issue, a new drug family was developed for intracellular delivery of
Externí odkaz:
https://doaj.org/article/f4c45ff1604b44f9a8e00b84babc041b
Autor:
James A. Swenberg, Vernon E. Walker, Yutai Li, Karupiah Jayaraj, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen
1,3-Butadiene is an important industrial chemical used in the production of synthetic rubber and is also found in gasoline and combustion products. It is a multispecies, multisite carcinogen in rodents, with mice being the most sensitive species. 1,3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f309f151862cccc299191958738b4d0
https://doi.org/10.1158/0008-5472.c.6493818.v1
https://doi.org/10.1158/0008-5472.c.6493818.v1
1,3-Butadiene (BD) is an important industrial and environmental chemical classified as a human carcinogen based on epidemiologic studies in occupationally exposed workers and animal studies in laboratory rats and mice. BD is metabolically activated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::404ff08b6f6e6853dd8d2c65d486d911
https://doi.org/10.1158/0008-5472.c.6499391.v1
https://doi.org/10.1158/0008-5472.c.6499391.v1
Supplementary Figures 1-3 from Molecular Dosimetry of 1,2,3,4-Diepoxybutane–Induced DNA-DNA Cross-Links in B6C3F1 Mice and F344 Rats Exposed to 1,3-Butadiene by Inhalation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f4d409f7b2b9d4ef62e76a702967f6
https://doi.org/10.1158/0008-5472.22379906.v1
https://doi.org/10.1158/0008-5472.22379906.v1
Autor:
James A. Swenberg, Vernon E. Walker, Yutai Li, Karupiah Jayaraj, Patricia B. Upton, Nadia I. Georgieva, Gunnar Boysen
Supplementary Table 1 from Analysis of Diepoxide-Specific Cyclic N-Terminal Globin Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f29e0921f29abf68c8efa001cf3e8cb
https://doi.org/10.1158/0008-5472.22363647
https://doi.org/10.1158/0008-5472.22363647
Autor:
Dorothea K. Torous, Lawrence J. Saubermann, Yuhchyau Chen, Svetlana L. Avlasevich, David P. Lovell, Stephen D. Dertinger, Vernon E. Walker, James T. MacGregor, Mona Khattab, Jeffrey C. Bemis, Ayesha Baig
Publikováno v:
Environ Mol Mutagen
We previously described flow cytometry-based methods for scoring the incidence of micronucleated reticulocytes (MN-RET) and PIG-A mutant phenotype reticulocytes (MUT RET) in rodent and human blood samples. The current report describes important metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53bbdb1730702474576b03c972132a5
https://doi.org/10.1002/em.22393
https://doi.org/10.1002/em.22393
Autor:
Michael J Bauer, George R. Douglas, Patricia B. Upton, Dale M. Walker, Vernon E. Walker, Timothy R. Fennell, James A. Swenberg
Publikováno v:
Chemical Research in Toxicology. 33:1609-1622
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in multiple organs/tissues of rats by unresolved mechanisms. For this report, evidence for ACN-induced direct/indirect DNA damage and mutagenesis was investigated by ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc467225c5df0ebce55722fd219b3a78
https://doi.org/10.1021/acs.chemrestox.0c00153
https://doi.org/10.1021/acs.chemrestox.0c00153
Publikováno v:
Chem Res Toxicol
Acrylonitrile (ACN), which is a widely used industrial chemical, induces cancers in the mouse via unresolved mechanisms. For this report, complementary and previously described methods were used to assess in vivo genotoxicity and/or mutagenicity of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a5f3f025ea50051a8d3a4574fe0b27
https://europepmc.org/articles/PMC7477827/
https://europepmc.org/articles/PMC7477827/
Publikováno v:
Dose-Response, Vol 2 (2004)
A protective apoptosis-mediated (PAM) process that is turned on in mammalian cells by low-dose photon (X and γ) radiation and appears to also be turned on by the genotoxic chemical ethylene oxide is discussed. Because of the PAM process, exposure to
Externí odkaz:
https://doaj.org/article/ae015ef453544321b3c89a65f9dcd0fa
Autor:
Dewakar Sangaraju, Yesha Patel, Natalia Y. Tretyakova, Daniel O. Stram, Vernon E. Walker, Dorothy K. Hatsukami, Irina Stepanov, Emily J. Boldry
Publikováno v:
Chemical Research in Toxicology. 30:678-688
1,3-Butadiene (BD) is an important industrial and environmental chemical classified as a known human carcinogen. Occupational exposure to BD in the polymer and monomer industries is associated with an increased incidence of lymphoma. BD is present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4849171f564f2ae68a58ec47ea20736
https://doi.org/10.1021/acs.chemrestox.6b00407
https://doi.org/10.1021/acs.chemrestox.6b00407