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pro vyhledávání: '"Vernon A. Benignus"'
Autor:
Vernon A. Benignus
Publikováno v:
Carbon Monoxide ISBN: 9780429260674
Short-term exposure to carbon monoxide (CO) will produce frank behavioral effects if carboxyhemoglobin (COHb) rises to sufficiendy high levels. Although there are many reports of effects below the level of COHb needed to produce unconsciousness, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77c178f1f34cf54a879b9bd425c677a5
https://doi.org/10.1201/9780429260674-10
https://doi.org/10.1201/9780429260674-10
Publikováno v:
Risk Analysis. 31:1935-1948
Acute solvent exposures may contribute to automobile accidents because they increase reaction time and decrease attention, in addition to impairing other behaviors. These effects resemble those of ethanol consumption, both with respect to behavioral
Publikováno v:
Journal of Toxicology and Environmental Health, Part A. 72:824-831
The literature concerning the neurobehavioral and neurophysiological effects of long-term exposure to perchloroethylene (PERC) in humans was meta-analyzed to provide a quantitative review and synthesis in the form of dose-effect curves. The useable d
Autor:
Vernon A. Benignus, Ambuja S. Bale, Mark Bercegeay, Philip J. Bushnell, Timothy J. Shafer, Q. T. Krantz, Elaina M. Kenyon, William K. Boyes
Publikováno v:
Toxicological Sciences. 99:572-581
Acute exposure to toluene was assessed in two experiments to determine the relationship between brain toluene concentration and changes in neurophysiological function. The concentration of toluene in brain tissue at the time of assessment was estimat
Autor:
Tracey E. Samsam, Q. T. Krantz, Vernon A. Benignus, Wendy M. Oshiro, Elaina M. Kenyon, Philip J. Bushnell
Publikováno v:
Toxicological Sciences. 99:181-189
Knowledge of the appropriate metric of dose for a toxic chemical facilitates quantitative extrapolation of toxicity observed in the laboratory to the risk of adverse effects in the human population. Here, we utilize a physiologically based toxicokine
Publikováno v:
NeuroToxicology. 28:221-226
Synthesizing information about the acute neurotoxicity of organic solvents into predictive relationships between exposure and effect in humans is difficult because (1) data are usually derived from experimental animals whose sensitivity to the chemic
Publikováno v:
Toxicology Mechanisms and Methods. 16:27-36
Realistic simulation of environmental exposure scenarios requires dynamic methods in which exposures and human activities vary continuously as a function of time. Simulation of such complex scenarios is, with conventional physiologically based method
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1109-1118
The mechanisms underlying the acute neurophysiological and behavioral effects of volatile organic compounds (VOCs) remain to be elucidated. However, the function of neuronal ion channels is perturbed by VOCs. The present study examined effects of tol
Autor:
William K. Boyes, Vernon A. Benignus, Todd Krantz, Mark Bercegeay, Jane Ellen Simmons, Marina V. Evans
Publikováno v:
Toxicological Sciences. 87:187-196
The relationship between the concentration of trichloroethylene (TCE) in the brain and changes in brain function, indicated by the amplitude of steady-state pattern-elicited visual evoked potentials (VEP), was evaluated in Long-Evans rats. VEPs were
Autor:
William K. Boyes, Vernon A. Benignus, Paul M.L. Janssen, Jane Ellen Simmons, Christopher R. Eklund, Philip J. Bushnell
Publikováno v:
Environmental Toxicology and Pharmacology. 19:599-605
Risk assessment procedures can be improved through better understanding and use of tissue dose information and linking tissue dose level to adverse outcomes. For volatile organic compounds, such as toluene and trichloroethylene (TCE), blood and brain