Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Vernon, Knight"'
Autor:
Nadezhda V. Koshkina, Brian E. Gilbert, J. Clifford Waldrep, Vernon Knight, Beppino C. Giovanella, Eugenie S. Kleinerman
Publikováno v:
Annals of the New York Academy of Sciences. 922:151-163
The purpose of this study was to test the anticancer properties of the water-insoluble derivative of camptothecin, 9-nitrocamptothecin (9NC), administered in a liposome formulation (L-9NC) in aerosol to mice with subcutaneous xenografts of three huma
Autor:
Vernon Knight, Claire F. Verschraegen, Robert A. Newman, Brian E. Gilbert, Garrett L. Walsh, Evelyne M. Loyer, Armando J. Huaringa
Publikováno v:
Clinical Cancer Research. 10:2319-2326
Purpose: The purpose is to evaluate the feasibility and safety of aerosol administration of the topoisomerase I inhibitor, 9-nitrocamptothecin, in a liposome formulation, and to recommend a dosage for a Phase II trial for an 8-week daily treatment sc
Autor:
Brian E. Gilbert, Luz Roberts, Charles L. Densmore, J.C. Waldrep, Vernon Knight, Nadezhda V. Koshkina, Ajay Gautam, Sara Melton
Publikováno v:
Gene Therapy. 9:353-357
Growth inhibition of established tumor metastases in the lungs poses a difficult challenge for most clinical settings in spite of extensive multi-modality approaches. Aerosol delivery of drugs and genes holds promise for the treatment of disseminated
Publikováno v:
Inhalation Toxicology. 14:185-197
9-Nitrocamptothecin (9-NC) dilauroylphosphatidylcholine (DLPC) liposome aerosol was evaluated for potential toxicity in an 8-wk, subacute toxicity study in dogs. Fourteen adult dogs were divided into 2 groups with 10 animals in the 9-NC-DLPC treatmen
Autor:
Laura L. Worth, Vernon Knight, Charles L. Densmore, Ajay Gautam, Yuen Kai Fung, Eugenie S. Kleinerman, J. Clifford Waldrep, Bo Xu, Anne T'ang, Shu Fang Jia
Publikováno v:
Cancer Gene Therapy. 8:619-627
Lung metastases are a frequent complication of osteosarcoma and a treatment that would reduce the severity of this complication would be of great benefit to patients. We have used a formulation consisting of polyethyleneimine (PEI) and a p53 gene adm
Autor:
Balbir Bhogal, Bo Xu, Frank M. Orson, Pascal Hua, Berma M. Kinsey, J. Clifford Waldrep, Vernon Knight, Charles L. Densmore
Publikováno v:
Molecular Therapy. 1(2):180-188
Aerosol delivery of plasmid DNA to the lungs offers the possibility of direct application of gene preparations to pulmonary surfaces as a means of treating a variety of genetic pulmonary disorders. However, the process of jet nebulization rapidly deg
Publikováno v:
The Journal of Gene Medicine. 1:251-264
Background A major challenge of gene therapy is the efficient transfer of genes to cell sites where effective transfection can occur. The impact of jet nebulization on DNA structural and functional integrity has been problematic for the aerosol deliv
Publikováno v:
International Journal of Pharmaceutics. 152:27-36
Development of liposomal formulations for pulmonary delivery with jet nebulizers has vast potential for future aerosol therapies. Different variables determine the therapeutic efficacy of aerosols, including formulation. The purpose of this study was
Autor:
Peter W. Scherer, Vernon Knight, J. Clifford Waldrep, Melanie B. Black, Caroline M. Knight, William L. Eschenbacher, Brian E. Gilbert
Publikováno v:
Chest. 111:316-323
Study objective To test the tolerance and safety of single doses of beclomethasone dipropionate (Bec)-dilauroylphosphatidylcholine (DLPC) liposome aerosol in volunteers. Design Single-dose inhalations of liposome preparations of Bec-DLPC and DLPC alo
Autor:
Brian E. Gilbert, J. Clifford Waldrep, Melanie B. Black, Jerry Bennick Charles Montgomery Vernon Knight
Publikováno v:
Inhalation Toxicology. 9:717-730
Cyclosporin A (CsA)-dilauroylphosphatidylcholine (DLPC) liposome aerosol was evaluated for potential toxicity in a 28-day, acute toxicity study in rats. Rats of both sexes were housed in a nose-only chamber and exposed to aerosols of room air, water,