Pyrimidine thioethers: A novel class of antidepressant agents, endowed with anxiolytic, performance enhancing and nootropic activity

Autor: Fioravanti, Rossella, Proia, Eleonora, Tyurenkov, Ivan N., Kurkin, Denis V., Bakulin, Dmitry A., Kovalev, Nikolay S., Sheikin, Dmitry S., Kirillov, Ivan A., Nawrozkij, Maxim B., Vernigora, Andrey A., Brunilina, Leila L., Fiorentino, Francesco, Mladenović, Milan, Rotili, Dante, Ragno, Rino

Publikováno v: In European Journal of Medicinal Chemistry 5 January 2023 245 Part 2

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Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors

Autor: Burmistrov, Vladimir, Morisseau, Christophe, Karlov, Dmitry, Pitushkin, Dmitry, Vernigora, Andrey, Rasskazova, Elena, Butov, Gennady M., Hammock, Bruce D.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 September 2020 30(18)

Structure-Based Design, Synthesis, and Biological Evaluation of the Cage-Amide Derived Orthopox Virus Replication Inhibitors.

Autor: Mozhaitsev ES; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia., Suslov EV; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia., Rastrepaeva DA; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia., Yarovaya OI; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia., Borisevich SS; Laboratory of Chemical Physics, Laboratory of Physical and Chemical Methods of Analysis, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia., Khamitov EM; Laboratory of Chemical Physics, Laboratory of Physical and Chemical Methods of Analysis, Ufa Institute of Chemistry Ufa Federal Research Center, 71 Pr. Oktyabrya, 450078 Ufa, Russia., Kolybalov DS; Synchrotron Radiation Facility SKIF, G.K. Boreskov Institute of Catalysis SB RAS, 630559 Koltsovo, Russia.; Scientific Educational Center 'Institute of Chemical Technology', Novosibirsk State University, 630090 Novosibirsk, Russia., Arkhipov SG; Synchrotron Radiation Facility SKIF, G.K. Boreskov Institute of Catalysis SB RAS, 630559 Koltsovo, Russia.; Scientific Educational Center 'Institute of Chemical Technology', Novosibirsk State University, 630090 Novosibirsk, Russia., Bormotov NI; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Shishkina LN; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Serova OA; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Brunilin RV; Department of Analytical, Physical Chemistry and Polymer Chemistry and Physics, Department of Organic Chemistry, Volgograd State Technical University Lenina, Avenue 28, 400005 Volgograd, Russia., Vernigora AA; Department of Analytical, Physical Chemistry and Polymer Chemistry and Physics, Department of Organic Chemistry, Volgograd State Technical University Lenina, Avenue 28, 400005 Volgograd, Russia., Nawrozkij MB; Center of Translational Medicine, Sirius University of Science and Technology, Olympic Avenue 1, Krasnodar Krai, 354340 Sirius, Russia., Agafonov AP; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Maksyutov RA; State Research Center of Virology and Biotechnology VECTOR, Rospotrebnadzor, 630559 Koltsovo, Russia., Volcho KP; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia., Salakhutdinov NF; Department of Medicinal Chemistry, N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry SB RAS, Lavrentyev Ave. 9, 630090 Novosibirsk, Russia.

Publikováno v: Viruses [Viruses] 2022 Dec 21; Vol. 15 (1). Date of Electronic Publication: 2022 Dec 21.