Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Vernetti LA"'
Autor:
Grandis, Jennifer, Gough, AH, Chen, N, Shun, TY, Lezon, TR, Boltz, RC, Reese, CE, Wagner, J, Vernetti, LA, Grandis, JR, Lee, AV
Publikováno v:
Grandis, Jennifer; Gough, AH; Chen, N; Shun, TY; Lezon, TR; Boltz, RC; et al.(2014). Identifying and quantifying heterogeneity in high content analysis: Application of heterogeneity indices to drug discovery. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8zt9r6sz
One of the greatest challenges in biomedical research, drug discovery and diagnostics is understanding how seemingly identical cells can respond differently to perturbagens including drugs for disease treatment. Although heterogeneity has become an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::d5c01bf9056370c6519f980a2e9fe1d6
http://www.escholarship.org/uc/item/8zt9r6sz
http://www.escholarship.org/uc/item/8zt9r6sz
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Akademický článek
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Autor:
Xia M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., Varmazyad M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., Pla-Palacín I; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., Gavlock DC; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., DeBiasio R; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., LaRocca G; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., Reese C; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States., Florentino RM; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States., Faccioli LAP; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States., Brown JA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Vernetti LA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Schurdak M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Stern AM; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Gough A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States., Behari J; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States.; Division of Gastroenterology, Hepatology and Nutrition, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Soto-Gutierrez A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States., Taylor DL; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Computational and System Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States., Miedel MT; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, United States.
Publikováno v:
Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Sep 11; Vol. 12, pp. 1423936. Date of Electronic Publication: 2024 Sep 11 (Print Publication: 2024).
Autor:
Beaudoin JJ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Clemens L; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Miedel MT; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Gough A; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Zaidi F; Metabolon Inc., Durham, NC 27713, USA., Ramamoorthy P; Metabolon Inc., Durham, NC 27713, USA., Wong KE; Metabolon Inc., Durham, NC 27713, USA., Sarangarajan R; Metabolon Inc., Durham, NC 27713, USA., Battista C; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Shoda LKM; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Siler SQ; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Taylor DL; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Howell BA; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA., Vernetti LA; Department of Computational and Systems Biology, Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15219, USA., Yang K; DILIsym Services Division, Simulations Plus Inc., Research Triangle Park, Durham, NC 27709, USA.
Publikováno v:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 02; Vol. 24 (11). Date of Electronic Publication: 2023 Jun 02.
Autor:
Argemi J; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA.; Liver Unit, Clínica Universidad de Navarra, University of Navarra, Pamplona, 31008, Spain., Latasa MU; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain., Atkinson SR; Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK., Blokhin IO; Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Massey V; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Gue JP; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA., Cabezas J; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA.; Departament of Hepatology, Marqués de Valdecilla University Hospital, Santander, 39008, Spain., Lozano JJ; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Van Booven D; John P. Hussman Institute of Human Genomics. Miller School of Medicine, University of Miami, Miami, FL, 33136, USA., Bell A; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Cao S; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Vernetti LA; University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Arab JP; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA.; Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile., Ventura-Cots M; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA., Edmunds LR; Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Fondevila C; Liver Transplant Unit, Department of Surgery, Hospital Clinic, University of Barcelona, Barcelona, 08036, Spain., Stärkel P; Service d'Hépato-gastroentérologie, Cliniques Universitaires Saint-Luc and Laboratory of Hepatogastroenterology, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain, Brussels, 1200, Belgium., Dubuquoy L; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Louvet A; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Odena G; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA., Gomez JL; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Aragon T; Department of Gene Therapy and Regulation, Center for Applied Medical Research, University of Navarra, Pamplona, 31008, Spain., Altamirano J; Liver Unit, Department of Internal Medicine, Vall d'Hebron Institut de Recerca. Internal Medicine Department, Hospital Quiron Salud, Barcelona, 08035, Spain., Caballeria J; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Jurczak MJ; Department of Medicine, Division of Endocrinology and Metabolism, Center for Metabolic and Mitochondrial Medicine, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Taylor DL; University of Pittsburgh Drug Discovery Institute, Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA, 15261, USA., Berasain C; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain.; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain., Wahlestedt C; Center for Therapeutic Innovation and Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, 33136, USA., Monga SP; Departments of Pathology and Medicine, Pittsburgh Liver Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA., Morgan MY; UCL Institute for Liver and Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, WC1E 6BT, UK., Sancho-Bru P; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain.; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, 08036, Spain., Mathurin P; Service des Maladies de l'appareil digestif, CHU Lille. Inserm LIRIC - UMR995, University of Lille, Lille, 59000, France., Furuya S; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77845, USA., Lackner C; Medical University of Graz, Institute of Pathology, Graz, 8036, Austria., Rusyn I; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77845, USA., Shah VH; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA., Thursz MR; Division of Digestive Diseases, Department of Surgery and Cancer, Imperial College London, London, SW7 2AZ, UK., Mann J; Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., Avila MA; Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, 31008, Spain.; Centro de Investigacion Biomedica en Red, Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, 28029, Spain., Bataller R; Division of Gastroenterology, Hepatology and Nutrition, Pittsburgh Liver Research Center, University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, 15261, USA. bataller@pitt.edu.; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition and Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27516, USA. bataller@pitt.edu.
Publikováno v:
Nature communications [Nat Commun] 2023 Feb 10; Vol. 14 (1), pp. 757. Date of Electronic Publication: 2023 Feb 10.
Autor:
Lefever DE; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Miedel MT; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Pei F; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., DiStefano JK; Diabetes and Fibrotic Disease Unit, Translational Genomics Research Institute TGen, Phoenix, AZ 85004, USA., Debiasio R; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Shun TY; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Saydmohammed M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Chikina M; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA., Vernetti LA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Soto-Gutierrez A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA., Monga SP; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Bataller R; Division of Gastroenterology Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA., Behari J; Division of Gastroenterology Hepatology and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.; UPMC Liver Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Yechoor VK; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA., Bahar I; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Gough A; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Stern AM; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA., Taylor DL; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Publikováno v:
Metabolites [Metabolites] 2022 Jun 07; Vol. 12 (6). Date of Electronic Publication: 2022 Jun 07.