Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Autor: Poe, Michael M., Methuku, Kashi Reddy, Guanguan Li, Verma, Ashwini R., Teske, Kelly A., Stafford, Douglas C., Arnold, Leggy A., Cramer, Jeffrey W., Jones, Timothy M., Cerne, Rok, Krambis, Michael J., Witkin, Jeffrey M., Jambrina, Enrique, Rehman, Sabah, Ernst, Margot, Cook, James M., Schkeryantz, Jeffrey M.

Publikováno v: Journal of Medicinal Chemistry; Dec2016, Vol. 59 Issue 23, p10800-10806, 7p

Synthesis and Characterization of a Novel γ-Aminobutyric Acid Type A (GABA A ) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy.

Autor: Poe MM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Methuku KR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Li G; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Verma AR; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Teske KA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Stafford DC; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Arnold LA; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Cramer JW; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States., Jones TM; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States., Cerne R; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States., Krambis MJ; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States., Witkin JM; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States., Jambrina E; Lilly Research Laboratories, Eli Lilly and Company , 28108 Alcobendas, Spain., Rehman S; Department for Molecular Neurosciences, Medical University of Vienna , 1090 Vienna, Austria., Ernst M; Department for Molecular Neurosciences, Medical University of Vienna , 1090 Vienna, Austria., Cook JM; Department of Chemistry and Biochemistry and the Milwaukee Institute for Drug Discovery, University of Wisconsin-Milwaukee , Milwaukee, Wisconsin 53201, United States., Schkeryantz JM; Lilly Research Laboratories, Eli Lilly and Company , Indianapolis, Indiana 42685, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Dec 08; Vol. 59 (23), pp. 10800-10806. Date of Electronic Publication: 2016 Nov 28.