Longitudinal change in mitochondrial heteroplasmy exhibits positive selection for deleterious variants.

Autor: Kuiper LM; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Shi W; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Verlouw J; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Hong YS; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Arp P; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Puiu D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Broer L; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands., Xie J; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Newcomb C; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Rich SS; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Bader JS; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Guallar E; Department of Epidemiology and Medicine, and Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health. Baltimore, MD, USA., van Meurs JBJ; Genetic Laboratory, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands.; Department of Orthopeadics & Sports Medicine, Erasmus MC, Rotterdam, the Netherlands., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Apr 03. Date of Electronic Publication: 2024 Apr 03.

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Autor: Porcu, E., Rueger, S., Lepik, K., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Bonder, M.J., Boomsma, D., Christiansen, M., Claringbould, A., Deelen, P., Esko, T., Fave, M.J., Franke, L., Frayling, T., Gharib, S.A., Gibson, G., Heijmans, B.T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg-Guzman, J., Kukushkina, V., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U.M., Mei, H.L., Milani, L., Montgomery, G.W., Muller-Nurasyid, M., Nauck, M., Nivard, M., Penninx, B., Perola, M., Pervjakova, N., Pierce, B.L., Powell, J., Prokisch, H., Psaty, B.M., Raitakari, O.T., Ripatti, S., Rotzschke, O., Saha, A., Scholz, M., Schramm, K., Seppala, I., Slagboom, E.P., Stehouwer, C.D.A., Stumvoll, M., Sullivan, P., Hoen, P.A.C. 't, Teumer, A., Thiery, J., Tong, L., Tonjes, A., Dongen, J. van, Iterson, M. van, Meurs, J. van, Veldink, J.H., Verlouw, J., Visscher, P.M., Volker, U., Vosa, U., Westra, H.J., Wijmenga, C., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F.T., Beekman, M., Boomsma, D.I., Bot, J., Deelen, J., Hofman, B.A., Hottenga, J.J., Isaacs, A., Jhamai, P.M., Kielbasa, S.M., Lakenberg, N., Luijk, R., Mei, H., Moed, M., Nooren, I., Pool, R., Schalkwijk, C.G., Slagboom, P.E., Suchiman, H.E.D., Swertz, M.A., Tigchelaar, E.F., Uitterlinden, A.G., Berg, L.H. van den, Breggen, R. van der, Kallen, C.J.H. van der, Dijk, F. van, Duijn, C.M. van, Galen, M. van, Greevenbroek, M.M.J. van, Heemst, D. van, Rooij, J. van, Van't Hof, P., Zwet, E.W. van, Vermaat, M., Verbiest, M., Verkerk, M., Zhernakova, D.V., Zhernakova, S., Santoni, F.A., Reymond, A., Kutalik, Z., eQTLGen Consortium, BIOS Consortium

Publikováno v: Porcu, E, Rüeger, S, Lepik, K, eQTLGen Consortium, BIOS Consortium, Santoni, F, Reymond, A & Kutalik, Z 2019, ' Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits ', Nature Communications, vol. 10, no. 1, 3300 . https://doi.org/10.1038/s41467-019-10936-0
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, 10:3300. Nature Publishing Group
eQTLGen Consortium & BIOS Consortium 2019, ' Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits ', Nature Communications, vol. 10, no. 1, 3300 . https://doi.org/10.1038/s41467-019-10936-0
Nat. Commun. 10:3300 (2019)
Nature Communications, 10(1):3300. Nature Publishing Group
Nature Communications, 10(1):3300. Nature Publishing Group UK
Nature communications, vol. 10, no. 1, pp. 3300
Nature Communications, 10
Porcu, E, Kutalik, Z, eQTLGen Consortium, BIOS Consortium, Boomsma, D I, Nivard, M G, Hottenga, J J, Pool, R & van Dongen, J 2019, ' Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits ', Nature Communications, vol. 10, no. 1, 3300 . https://doi.org/10.1038/s41467-019-10936-0

Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eef251064cec97623fab5b0fca75810
http://www.scopus.com/inward/record.url?scp=85069729041&partnerID=8YFLogxK

Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits

Autor: Porcu, E. (Eleonora), Rueger, S. (Sina), Lepik, K. (Kaido), Agbessi, M. (Mawusse), Ahsan, H. (Habibul), Alves, I. (Isabel), Andiappan, A. (Anand), Arindrarto, W. (Wibowo), Awadalla, P. (Philip), Battle, A. (Alexis), Beutner, F. (Frank), Bonder, M. J. (Marc Jan), Boomsma, D. (Dorret), Christiansen, M. (Mark), Claringbould, A. (Annique), Deelen, P. (Patrick), Esko, T. (Tonu), Fave, M.-J. (Marie-Julie), Franke, L. (Lude), Frayling, T. (Timothy), Gharib, S. A. (Sina A.), Gibson, G. (Gregory), Heijmans, B. T. (Bastiaan T.), Hemani, G. (Gibran), Jansen, R. (Rick), Kahonen, M. (Mika), Kalnapenkis, A. (Anette), Kasela, S. (Silva), Kettunen, J. (Johannes), Kim, Y. (Yungil), Kirsten, H. (Holger), Kovacs, P. (Peter), Krohn, K. (Knut), Kronberg-Guzman, J. (Jaanika), Kukushkina, V. (Viktorija), Lee, B. (Bernett), Lehtimaki, T. (Terho), Loeffler, M. (Markus), Marigorta, U. M. (Urko M.), Mei, H. (Hailang), Milani, L. (Lili), Montgomery, G. W. (Grant W.), Mueler-Nurasyid, M. (Martina), Nauck, M. (Matthias), Nivard, M. (Michel), Penninx, B. (Brenda), Perola, M. (Markus), Pervjakova, N. (Natalia), Pierce, B. L. (Brandon L.), Powell, J. (Joseph), Prokisch, H. (Holger), Psaty, B. M. (Bruce M.), Raitakari, O. T. (Olli T.), Ripatti, S. (Samuli), Rotzschke, O. (Olaf), Saha, A. (Ashis), Scholz, M. (Markus), Schramm, K. (Katharina), Seppala, I. (Ilkka), Slagboom, E. P. (Eline P.), Stehouwer, C. D. (Coen D. A.), Stumvoll, M. (Michael), Sullivan, P. (Patrick), Teumer, A. (Alexander), Thiery, J. (Joachim), Tong, L. (Lin), Tonjes, A. (Anke), van Dongen, J. (Jenny), van Iterson, M. (Maarten), van Meurs, J. (Joyce), Veldink, J. H. (Jan H.), Verlouw, J. (Joost), Visscher, P. M. (Peter M.), Volker, U. (Uwe), Vosa, U. (Urmo), Westra, H.-J. (Harm-Jan), Wijmenga, C. (Cisca), Yaghootkar, H. (Hanieh), Yang, J. (Jian), Zeng, B. (Biao), Zhang, F. (Futao), Beekman, M. (Marian), Boomsma, D. I. (Dorret I.), Bot, J. (Jan), Deelen, J. (Joris), Hofman, B. A. (Bert A.), Hottenga, J. J. (Jouke J.), Isaacs, A. (Aaron), Jhamai, P. M. (P. Mila), Kielbasa, S. M. (Szymon M.), Lakenberg, N. (Nico), Luijk, R. (Rene), Mei, H. (Hailiang), Moed, M. (Matthijs), Nooren, I. (Irene), Pool, R. (Rene), Schalkwijk, C. G. (Casper G.), Slagboom, P. E. (P. Eline), Suchiman, H. E. (H. Eka D.), Swertz, M. A. (Morris A.), Tigchelaar, E. F. (Ettje F.), Uitterlinden, A. G. (Andre G.), van den Berg, L. H. (Leonard H.), van der Breggen, R. (Ruud), van der Kallen, C. J. (Carla J. H.), van Dijk, F. (Freerk), van Duijn, C. M. (Cornelia M.), van Galen, M. (Michiel), van Greevenbroek, M. M. (Marleen M. J.), van Heemst, D. (Diana), van Rooij, J. (Jeroen), Van't Hof, P. (Peter), van Zwet, E. W. (Erik. W.), Vermaat, M. (Martijn), Verbiest, M. (Michael), Verkerk, M. (Marijn), Zhernakova, D. V. (Dasha V.), Zhernakova, S. (Sasha), Santoni, F. A. (Federico A.), Reymond, A. (Alexandre), Kutalik, Z. (Zoltan)

Genome-wide association studies (GWAS) have identified thousands of variants associated with complex traits, but their biological interpretation often remains unclear. Most of these variants overlap with expression QTLs, indicating their potential in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::5d4f24d031228650820d283cc0d4fac4
http://urn.fi/urn:nbn:fi-fe202003117859

A bioinformatics pipeline for estimating mitochondrial DNA copy number and heteroplasmy levels from whole genome sequencing data.

Autor: Battle SL; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Puiu D; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Verlouw J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Broer L; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Fetterman JL; Evans Department of Medicine and the Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA, USA., Liu C; Framingham Heart Study, Boston University School of Medicine, Boston, MA, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Publikováno v: NAR genomics and bioinformatics [NAR Genom Bioinform] 2022 May 17; Vol. 4 (2), pp. lqac034. Date of Electronic Publication: 2022 May 17 (Print Publication: 2022).

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression.

Autor: Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. urmo.vosa@gmail.com.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. urmo.vosa@gmail.com., Claringbould A; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. anniqueclaringbould@gmail.com.; Oncode Institute, Amsterdam, the Netherlands. anniqueclaringbould@gmail.com.; Structural & Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. anniqueclaringbould@gmail.com., Westra HJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Bonder MJ; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Deelen P; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands.; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands.; Department of Genetics, University Medical Centre Utrecht, Utrecht, the Netherlands., Zeng B; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA., Kirsten H; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Saha A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA., Kreuzhuber R; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Yazar S; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia., Brugge H; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Oelen R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., de Vries DH; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., van der Wijst MGP; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Kasela S; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Pervjakova N; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Alves I; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.; L'institut du thorax, Université de Nantes, CHU Nantes, INSERM, CNRS, Nantes, France., Favé MJ; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Agbessi M; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Christiansen MW; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Jansen R; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Tong L; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Teumer A; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany., Schramm K; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany., Hemani G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom., Verlouw J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Yaghootkar H; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom.; School of Life Sciences, College of Liberal Arts and Science, University of Westminster, London, United Kingdom.; Division of Medical Sciences, Department of Health Sciences, Luleå University of Technology, Luleå, Sweden., Sönmez Flitman R; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Brown A; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Population Health and Genomics, University of Dundee, Dundee, United Kingdom., Kukushkina V; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kalnapenkis A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Rüeger S; Lausanne University Hospital, Lausanne, Switzerland., Porcu E; Lausanne University Hospital, Lausanne, Switzerland., Kronberg J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Kettunen J; Computational Medicine, Faculty of Medicine, University of Oulu, Oulu, Finland.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Finnish Institute for Health and Welfare, Helsinki, Finland., Lee B; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Zhang F; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Qi T; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Hernandez JA; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia., Arindrarto W; Leiden University Medical Center, Leiden, the Netherlands., Beutner F; Heart Center Leipzig, Universität Leipzig, Leipzig, Germany., Dmitrieva J; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Elansary M; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Fairfax BP; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Georges M; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium., Heijmans BT; Leiden University Medical Center, Leiden, the Netherlands., Hewitt AW; Menzies Institute for Medical Research, School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.; Centre for Eye Research Australia, Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia., Kähönen M; Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Kim Y; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Knight JC; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Kovacs P; IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany., Krohn K; Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany., Li S; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Marigorta UM; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA.; Integrative Genomics Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Science and Technology Park, Derio, Spain.; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain., Mei H; Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands., Momozawa Y; Unit of Animal Genomics, WELBIO, GIGA-R & Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, University Hospital Munich, Ludwig Maximilian's University, Munich, Germany.; IBE, Faculty of Medicine, LMU Munich, Munich, Germany., Nauck M; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany., Nivard MG; Department of Biological Psychology, Faculty of Behaviour and Movement Sciences, Vrije Universiteit, Amsterdam, the Netherlands., Penninx BWJH; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Pritchard JK; Department of Biology, Stanford University, Stanford, CA, USA.; Department of Genetics, Stanford University, Stanford, CA, USA., Raitakari OT; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland., Rotzschke O; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Slagboom EP; Leiden University Medical Center, Leiden, the Netherlands., Stehouwer CDA; Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, the Netherlands., Stumvoll M; Department of Medicine, Universität Leipzig, Leipzig, Germany., Sullivan P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., 't Hoen PAC; Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, the Netherlands., Thiery J; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.; Institute for Laboratory Medicine, LIFE-Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany., Tönjes A; Department of Medicine, Universität Leipzig, Leipzig, Germany., van Dongen J; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., van Iterson M; Leiden University Medical Center, Leiden, the Netherlands., Veldink JH; UMC Utrecht Brain Center, University Medical Center Utrecht, Department of Neurology, Utrecht University, Utrecht, the Netherlands., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany., Warmerdam R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Oncode Institute, Amsterdam, the Netherlands., Wijmenga C; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands., Swertz M; Genomics Coordination Center, University Medical Centre Groningen, Groningen, the Netherlands., Andiappan A; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore., Montgomery GW; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Ripatti S; Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland.; Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Perola M; National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland., Kutalik Z; Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland., Dermitzakis E; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.; Institute of Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland., Bergmann S; Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland., Frayling T; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, United Kingdom., van Meurs J; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands., Prokisch H; Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany.; Institute of Human Genetics, Technical University Munich, Munich, Germany., Ahsan H; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Pierce BL; Department of Public Health Sciences, University of Chicago, Chicago, IL, USA., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Boomsma DI; Netherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute and Amsterdam Neuroscience, Amsterdam, the Netherlands., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA., Gharib SA; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Medicine, University of Washington, Seattle, WA, USA., Awadalla P; Computational Biology, Ontario Institute for Cancer Research, Toronto, Ontario, Canada., Milani L; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom., Downes K; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Stegle O; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.; Division of Computational Genomics and Systems Genetics, German Cancer Research Center, Heidelberg, Germany., Battle A; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA., Visscher PM; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Yang J; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Scholz M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany., Powell J; Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, New South Wales, Australia.; UNSW Cellular Genomics Futures Institute, University of New South Wales, Sydney, New South Wales, Australia., Gibson G; School of Biological Sciences, Georgia Tech, Atlanta, GA, USA., Esko T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Franke L; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. lude@ludesign.nl.; Oncode Institute, Amsterdam, the Netherlands. lude@ludesign.nl.

Publikováno v: Nature genetics [Nat Genet] 2021 Sep; Vol. 53 (9), pp. 1300-1310. Date of Electronic Publication: 2021 Sep 02.