Zobrazeno 1 - 10
of 3 384
pro vyhledávání: '"Verkhratsky, A"'
Autor:
Zhao, Ya-Fei, Ren, Wen-Jing, Zhang, Ying, He, Jin-Rong, Yin, Hai-Yan, Liao, Yang, Rubini, Patrizia, Deussing, Jan M., Verkhratsky, Alexei, Yuan, Zeng-Qiang, Illes, Peter, Tang, Yong
Extracellular adenosine 50-triphosphate (ATP) in the brain is suggested to be an etiological factor of major depressive disorder (MDD). It has been assumed that stress-released ATP stimulates P2X7 receptors (Rs) at the microglia, thereby causing neur
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A89098
https://ul.qucosa.de/api/qucosa%3A89098/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A89098/attachment/ATT-0/
The mood disorders, major depression (MD) and bipolar disorder (BD), have a high lifetime prevalence in the human population and accordingly generate huge costs for health care. Efficient, rapidly acting, and side-effect-free pharmaceuticals are hith
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84231
https://ul.qucosa.de/api/qucosa%3A84231/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84231/attachment/ATT-0/
Autor:
Xiaomin Huang, Junhua Qi, Yixun Su, Ying Zhou, Qi Wang, Taida Huang, Dongdong Xue, Yunxin Zeng, Alexei Verkhratsky, Benjie Zhou, Hui Chen, Chenju Yi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-11 (2024)
Abstract The impairment of the blood-brain barrier (BBB) has been increasingly recognised as a critical element in the early pathogenesis of Alzheimer’s disease (AD), prompting a focus on brain endothelial cells (BECs), which serve as the primary c
Externí odkaz:
https://doaj.org/article/33b4275d6b3c443b8177513955e237ed
Autor:
Brian G Oliver, Xiaomin Huang, Rochelle Yarak, Xu Bai, Qi Wang, Razia Zakarya, Karosham D. Reddy, Chantal Donovan, Richard Y. Kim, James Morkaya, Baoming Wang, Yik Lung Chan, Sonia Saad, Alen Faiz, David van Reyk, Alexei Verkhratsky, Chenju Yi, Hui Chen
Publikováno v:
Environment International, Vol 191, Iss , Pp 108971- (2024)
There is no safe level of air pollution for human health. Traffic-related particulate matter (PM2.5) is a major in-utero toxin, mechanisms of action of which are not fully understood. BALB/c dams were exposed to an Australian level of traffic PM2.5 (
Externí odkaz:
https://doaj.org/article/6fca2a75557a4402bb948d62629d5789
Autor:
Oliver, Brian G, Huang, Xiaomin, Yarak, Rochelle, Bai, Xu, Wang, Qi, Zakarya, Razia, Reddy, Karosham D., Donovan, Chantal, Kim, Richard Y., Morkaya, James, Wang, Baoming, Lung Chan, Yik, Saad, Sonia, Faiz, Alen, Reyk, David van, Verkhratsky, Alexei, Yi, Chenju, Chen, Hui
Publikováno v:
In Environment International September 2024 191
Publikováno v:
In Trends in Molecular Medicine July 2024 30(7):642-659
Autor:
Ye Liu, Zhenning Huang, Tian-Xiang Zhang, Bin Han, Guili Yang, Dongmei Jia, Li Yang, Qiang Liu, Alexander Y. L. Lau, Friedemann Paul, Alexei Verkhratsky, Fu-Dong Shi, Chao Zhang
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell receptor signaling as well as astrocyte–microglia interaction, which both contribute to evol
Externí odkaz:
https://doaj.org/article/9743515186dc49bfb082ad3ba3afc3e4
Autor:
Alexander Popov, Nadezda Brazhe, Kseniia Morozova, Konstantin Yashin, Maxim Bychkov, Olga Nosova, Oksana Sutyagina, Alexey Brazhe, Evgenia Parshina, Li Li, Igor Medyanik, Dmitry E. Korzhevskii, Zakhar Shenkarev, Ekaterina Lyukmanova, Alexei Verkhratsky, Alexey Semyanov
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract How aging affects cells of the human brain active milieu remains largely unknown. Here, we analyze astrocytes and neurons in the neocortical tissue of younger (22–50 years) and older (51–72 years) adults. Aging decreases the amount of re
Externí odkaz:
https://doaj.org/article/ceeb2da29c3a47b68b9403c949de291d
Autor:
Alexei Verkhratsky, Arthur Butt, Baoman Li, Peter Illes, Robert Zorec, Alexey Semyanov, Yong Tang, Michael V. Sofroniew
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-37 (2023)
Abstract Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in wa
Externí odkaz:
https://doaj.org/article/f78779f97bd142ebba86ea8ae5682acf