Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Verhezen P"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103123- (2024)
Summary: Here, we present a protocol to perform CRISPR-Cas9 genome editing in human resting primary natural killer (NK) and NK-92 cells. We describe steps for guide RNA selection, ribonucleoprotein (RNP) complex formation, delivery via Nucleofection,
Externí odkaz:
https://doaj.org/article/34be51c4937340bc921941d7ca0f8a8c
Autor:
Astrid Van den Eynde, Laura Gehrcken, Tias Verhezen, Ho Wa Lau, Christophe Hermans, Hilde Lambrechts, Tal Flieswasser, Delphine Quatannens, Gils Roex, Karen Zwaenepoel, Elly Marcq, Philippe Joye, Edgar Cardenas De La Hoz, Christophe Deben, Alessia Gasparini, Pierre Montay-Gruel, Maxim Le Compte, Eva Lion, Filip Lardon, Steven Van Laere, Vasiliki Siozopoulou, Diana Campillo-Davo, Jorrit De Waele, Patrick Pauwels, Julie Jacobs, Evelien Smits, Jonas R. M. Van Audenaerde
Publikováno v:
Journal of Hematology & Oncology, Vol 17, Iss 1, Pp 1-19 (2024)
Abstract Background It remains challenging to obtain positive outcomes with chimeric antigen receptor (CAR)-engineered cell therapies in solid malignancies, like colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC). A major obstacle is
Externí odkaz:
https://doaj.org/article/8761eb0063d942beb968b458b3b522ca
Autor:
E.J.S. Denessen, D.L. Van Den Kerkhof, M.L.J. Jeurissen, R.J.H. Wetzels, P.W.M. Verhezen, Y.M.C Henskens
Publikováno v:
Platelets, Vol 33, Iss 3, Pp 416-424 (2022)
Platelet function assays and global haemostasis assays are essential in diagnosing bleeding tendencies, with light transmission aggregometry (LTA) as golden standard. The Multiple Electrode Aggregation (Multiplate), platelet function assay (PFA) and
Externí odkaz:
https://doaj.org/article/96c36081712a4e2ca552b3322e5b4119
Akademický článek
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Autor:
Jorrit De Waele, Tias Verhezen, Sanne van der Heijden, Zwi N. Berneman, Marc Peeters, Filip Lardon, An Wouters, Evelien L. J. M. Smits
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-20 (2021)
Abstract Immunotherapy is currently under intensive investigation as a potential breakthrough treatment option for glioblastoma. Given the anatomical and immunological complexities surrounding glioblastoma, lymphocytes that infiltrate the brain to de
Externí odkaz:
https://doaj.org/article/4e74d57df4f94a0fbb9a416bc7ae9cce
Autor:
I.C.A. Munnix, R. Van Oerle, P. Verhezen, P. Kuijper, C.M. Hackeng, H.I.J. Hopman-Kerkhoff, F. Hudig, D. Van De Kerkhof, A. Leyte, M.P.M. De Maat, R.F.M. Oude Elferink, J. Ruinemans-Koerts, M. Schoorl, J. Slomp, H. Soons, A. Stroobants, E. Van Wijk, Y.M.C. Henskens
Publikováno v:
Platelets, Vol 32, Iss 4, Pp 516-523 (2021)
Light transmission aggregometry (LTA) is considered the gold standard method for evaluation of platelet function. However, there are a lot of variation in protocols (pre-analytical procedures and agonist concentrations) and results. The aim of our st
Externí odkaz:
https://doaj.org/article/7ecddd574f1344fb861b7143c1f442d9
Autor:
Anne-Marije Hulshof, Minka Vries, Paul Verhezen, Rick Wetzels, Mirella Haartmans, Renske Olie, Hugo Ten Cate, Yvonne Henskens
Publikováno v:
Platelets, Vol 32, Iss 4, Pp 463-468 (2021)
Platelet function tests (PFT), such as the Multiple Electrode Analyzer (Multiplate) and VerifyNow, show little concordance in patients using antiplatelet drugs. A major difference between these tests is the use of prostaglandin E1 (PGE1) to inhibit P
Externí odkaz:
https://doaj.org/article/e1e7d1340ec34817b6508d3b0c389a19
Autor:
Demi S Post, Arian van der Veer, Olaf E M G Schijns, Sylvia Klinkenberg, Kim Rijkers, G Louis Wagner, Vivianne H J M van Kranen-Mastenbroek, Paul C P H Willems, Paul W M Verhezen, Erik A M Beckers, Floor C J I Heubel-Moenen, Yvonne M C Henskens
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0264351 (2022)
IntroductionValproic acid (VPA) is a frequently prescribed anti-epileptic drug. Since its introduction side effects on hemostasis are reported. However, studies show conflicting results, and the clinical relevance is questioned. We aimed to determine
Externí odkaz:
https://doaj.org/article/00f4153321684ea989cf14475877706e
Autor:
Anne-Marije Hulshof, Renske H. Olie, Minka J. A. Vries, Paul W. M. Verhezen, Paola E. J. van der Meijden, Hugo ten Cate, Yvonne M. C. Henskens
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Aims: Patients using antithrombotic drugs after percutaneous coronary intervention (PCI) are at risk for bleeding and recurrent ischemia. We aimed to explore routine and tissue plasminogen activated (tPA) ROTEM results in a post-PCI population on dua
Externí odkaz:
https://doaj.org/article/aaba5e75ed38495885ccd269e845d179
Autor:
ter Beek, O., Pavlenko, D., Suck, M., Helfrich, S., Bolhuis-Versteeg, L., Snisarenko, D., Causserand, C., Bacchin, P., Aimar, P., van Oerle, R., Wetzels, R., Verhezen, P., Henskens, Y., Stamatialis, D.
Publikováno v:
In Separation and Purification Technology 15 October 2019 225:60-73