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Akademický článek

KIT promotes tumor stroma formation and counteracts tumor-suppressive TGFβ signaling in colorectal cancer

Autor: Emre Küçükköse, Niek A. Peters, Inge Ubink, Veere A. M. van Keulen, Roxanna Daghighian, André Verheem, Jamila Laoukili, Onno Kranenburg

Publikováno v: Cell Death and Disease, Vol 13, Iss 7, Pp 1-10 (2022)

Abstract Expression profiling has identified four consensus molecular subtypes (CMS1-4) in colorectal cancer (CRC). The receptor tyrosine kinase KIT has been associated with the most aggressive subtype, CMS4. However, it is unclear whether, and how,

Externí odkaz: https://doaj.org/article/ff70be75eeff4857b2be1828deac162e

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Akademický článek

Tissue clearing and immunostaining to visualize the spatial organization of vasculature and tumor cells in mouse liver

Autor: Nicola Frenkel, Susanna Poghosyan, Jan Willem van Wijnbergen, Lotte van den Bent, Liza Wijler, André Verheem, Inne Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn

Publikováno v: Frontiers in Oncology, Vol 13 (2023)

The liver has a complex and hierarchical segmental organization of arteries, portal veins, hepatic veins and lymphatic vessels. In-depth imaging of liver vasculature and malignancies could improve knowledge on tumor micro-environment, local tumor gro

Externí odkaz: https://doaj.org/article/e29b9526460f461f9d44df94e8ae2e22

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Akademický článek

Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model

Autor: Liza A. Wijler, Danielle A.E. Raats, Andre Verheem, Anna M. denOtter, Helene Rundqvist, Miriam vanDijk, Anne M. May, Onno Kranenburg

Publikováno v: JCSM Rapid Communications, Vol 5, Iss 1, Pp 117-129 (2022)

Abstract Background Physical activity is associated with a lower risk of colorectal cancer (CRC) and CRC‐specific mortality. However, evidence for a causal relationship between physical activity and disease progression is lacking. Here, we have use

Externí odkaz: https://doaj.org/article/6cdcace1a9c341049516dcf610708588

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Akademický článek

Modeling resistance of colorectal peritoneal metastases to immune checkpoint blockade in humanized mice

Autor: Onno Kranenburg, Hergen Spits, Julien Villaudy, Madalina Cercel, Miriam Koopman, Cornelis J A Punt, Jamila Laoukili, Andre Verheem, Inne H M Borel Rinkes, Emre Küçükköse, Balthasar A Heesters, Susan van Hal, Sylvia F Boj, Jeanine M L Roodhart

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 12 (2022)

Background The immunogenic nature of metastatic colorectal cancer (CRC) with high microsatellite instability (MSI-H) underlies their responsiveness to immune checkpoint blockade (ICB). However, resistance to ICB is commonly observed, and is associate

Externí odkaz: https://doaj.org/article/bfcad88f61be41c09cf923011ef6cf7d

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Akademický článek

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Akademický článek

Liver lymphatic drainage patterns follow segmental anatomy in a murine model

Autor: Nicola C. Frenkel, Susanna Poghosyan, André Verheem, Timothy P. Padera, Inne H. M. Borel Rinkes, Onno Kranenburg, Jeroen Hagendoorn

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

Abstract The liver’s cellular functions are sustained by a hierarchical, segmentally-organized vascular system. Additionally, liver lymphatic vessels are thought to drain to perihepatic lymph nodes. Surprisingly, while recent findings highlight the

Externí odkaz: https://doaj.org/article/83a9268bbc9c4e1cb850f89e226f267c

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