RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.

Autor: Van Eeckhoutte HP; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Donovan C; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia., Kim RY; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia., Conlon TM; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Ansari M; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.; Institute of Computational Biology, Helmholtz Munich, Munich, Germany., Khan H; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia., Jayaraman R; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia., Hansbro NG; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia., Dondelinger Y; VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Cell Death and Inflammation Unit, Ghent University, Ghent, Belgium., Delanghe T; VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Cell Death and Inflammation Unit, Ghent University, Ghent, Belgium., Beal AM; Immunology Research Unit, GlaxoSmithKline, Collegeville, PA, USA., Geddes B; Research, Prime Medicine Inc., Cambridge, MA, USA., Bertin J; Immunology and Inflammation Research Therapeutic Area, Sanofi, Cambridge, MA, USA., Vanden Berghe T; VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Cell Death and Inflammation Unit, Ghent University, Ghent, Belgium.; Department of Biomedical Sciences, University of Antwerp, Wilrijk, Belgium., De Volder J; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Maes T; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Vandenabeele P; VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Cell Death and Inflammation Unit, Ghent University, Ghent, Belgium., Vanaudenaerde BM; BREATHE, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Deforce D; NXTGNT, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Škevin S; NXTGNT, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.; Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Van Nieuwerburgh F; NXTGNT, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.; Laboratory of Pharmaceutical Biotechnology, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Verhamme FM; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Joos GF; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Idrees S; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia., Schiller HB; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Yildirim AÖ; Institute of Lung Health and Immunity (LHI), Comprehensive Pneumology Center (CPC), Helmholtz Munich, Member of the German Center for Lung Research (DZL), Munich, Germany., Faiz A; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia., Bertrand MJM; VIB-UGent Center for Inflammation Research, Department for Biomedical Molecular Biology, Cell Death and Inflammation Unit, Ghent University, Ghent, Belgium., Brusselle GG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium., Hansbro PM; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.; Centre for Inflammation, Centenary Institute and School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.; These authors contributed equally to this work., Bracke KR; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, University Hospital Ghent, Ghent, Belgium ken.bracke@UGent.be.; These authors contributed equally to this work.

Publikováno v: The European respiratory journal [Eur Respir J] 2023 Apr 01; Vol. 61 (4). Date of Electronic Publication: 2023 Apr 01 (Print Publication: 2023).

Epigenome-wide association study on diffusing capacity of the lung.

Autor: Terzikhan N; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; These authors contributed equally., Xu H; Dept of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; These authors contributed equally., Edris A; Dept of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Bracke KR; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Verhamme FM; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Stricker BHC; Dept of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands., Dupuis J; Dept of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; These authors contributed equally., Lahousse L; Dept of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.; These authors contributed equally., O'Connor GT; Pulmonary Center, Boston University Schools of Medicine and Public Health, Boston, MA, USA.; These authors contributed equally., Brusselle GG; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.; Dept of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; Dept of Respiratory Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, The Netherlands.; These authors contributed equally.

Publikováno v: ERJ open research [ERJ Open Res] 2021 Mar 15; Vol. 7 (1). Date of Electronic Publication: 2021 Mar 15 (Print Publication: 2021).

The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD.

Autor: De Smet EG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Van Eeckhoutte HP; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Avila Cobos F; Center for Medical Genetics, Ghent University, Ghent, Belgium., Blomme E; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Verhamme FM; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Provoost S; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Verleden SE; Department of Respiratory Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium., Venken K; Laboratory for Molecular Immunology and Inflammation, Department of Rheumatology, Ghent University, Ghent, Belgium.; VIB Inflammation Research Center, Ghent University, Ghent, Belgium., Maes T; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Joos GF; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Mestdagh P; Center for Medical Genetics, Ghent University, Ghent, Belgium., Brusselle GG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Bracke KR; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. ken.bracke@UGent.be.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2020 May; Vol. 13 (3), pp. 423-436. Date of Electronic Publication: 2019 Dec 09.

Bone morphogenetic protein 6 (BMP-6) modulates lung function, pulmonary iron levels and cigarette smoke-induced inflammation.

Autor: Verhamme FM; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. fien.verhamme@UGent.be., De Smet EG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Van Hooste W; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Delanghe J; Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium., Verleden SE; Department of Respiratory Medicine, University Hospital Gasthuisberg, Catholic University of Leuven, Leuven, Belgium., Joos GF; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Brusselle GG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Bracke KR; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2019 Mar; Vol. 12 (2), pp. 340-351. Date of Electronic Publication: 2018 Dec 12.

DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients.

Autor: Seys LJM; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium.; Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium., Widagdo W; Departments of Viroscience, Rotterdam, The Netherlands., Verhamme FM; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium., Kleinjan A; Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands., Janssens W; University Hospital Leuven, Respiratory Division and Rehabilitation, Leuven, Belgium., Joos GF; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium., Bracke KR; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium., Haagmans BL; Departments of Viroscience, Rotterdam, The Netherlands., Brusselle GG; Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University HospitalGhent, Belgium.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 Jan 06; Vol. 66 (1), pp. 45-53.