Obesity in acute alcoholic hepatitis increases morbidity and mortality

Autor: Parker, Richard, Kim, S.J., Im, G.Y., Nahas, J., Dhesi, B., Vergis, N., Sinha, A., Ghezzi, A., Rink, M.R., McCune, A., Aithal, G.P., Newsome, P.N., Weston, C.J., Holt, A., Gao, B.

Publikováno v: In EBioMedicine July 2019 45:511-518

IL-1 Signal Inhibition in Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial of Canakinumab.

Autor: Vergis N; Division of Digestive Diseases, Imperial College London, London, United Kingdom., Patel V; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom; Roger Williams Institute of Hepatology London, Foundation for Liver Research, London, United Kingdom; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Bogdanowicz K; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Czyzewska-Khan J; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Keshinro R; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Fiorentino F; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom; Nightingale-Saunders Clinical Trials and Epidemiology Unit, King's Clinical Trials Unit, King's College London, United Kingdom., Day E; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Middleton P; Division of Digestive Diseases, Imperial College London, London, United Kingdom., Atkinson S; Division of Digestive Diseases, Imperial College London, London, United Kingdom., Tranah T; Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, United Kingdom; School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Cross M; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Babalis D; Imperial College Clinical Trials Unit, Faculty of Medicine, Imperial College Lon London, United Kingdom., Foster N; Patient partner., Lord E; Division of Digestive Diseases, Imperial College London, London, United Kingdom., Quaglia A; Department of Cellular Pathology, UCL Cancer Institute, Royal Free Hospital, London, United Kingdom., Lloyd J; North West London Pathology, Charing Cross Hospital, London, United Kingdom., Goldin R; Division of Digestive Diseases, Imperial College London, London, United Kingdom., Rosenberg W; Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom., Parker R; Leeds Liver Unit, St James' Hospital, Leeds, United Kingdom., Richardson P; Liverpool University Hospitals NHS Trust, Liverpool, United Kingdom., Masson S; Faculty of Medical Sciences, Newcastle University Medical School, Newcastle upon Tyne, United Kingdom., Whitehouse G; Chelsea and Westminster Hospital NHS Foundation Trust, London, United Kingdom., Sieberhagan C; Liverpool University Hospitals NHS Trust, Liverpool, United Kingdom., Patch D; Institute for Liver and Digestive Health, Royal Free Hospital, London, United Kingdom., Naoumov N; London, United Kingdom., Dhanda A; Hepatology Research Group, Faculty of Health, University of Plymouth, Plymouth, United Kingdom., Forrest E; Department of Gastroenterology, Glasgow Royal Infirmary, University of Glasgow, Glasgow, United Kingdom., Thursz M; Division of Digestive Diseases, Imperial College London, London, United Kingdom. Electronic address: m.thursz@imperial.ac.uk.

Publikováno v: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2024 Aug 23. Date of Electronic Publication: 2024 Aug 23.

In severe alcohol-related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using IL-8 and micro-RNAs.

Autor: Tyson LD; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; The Liver Unit, St Mary's Hospital, London, UK., Atkinson S; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; The Liver Unit, St Mary's Hospital, London, UK., Hunter RW; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Allison M; Cambridge NIHR Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, UK., Austin A; Department of Hepatology, Royal Derby Hospital, Derby, UK., Dear JW; Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Forrest E; Department of Hepatology, Glasgow Royal Infirmary, Glasgow, UK.; University of Glasgow, Glasgow, UK., Liu T; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Lord E; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Masson S; Department of Hepatology, Newcastle Freeman Hospital, Newcastle upon Tyne, UK., Nunes J; Meso Scale Diagnostics, Gaithersburg, USA., Richardson P; Department of Hepatology, The Royal Liverpool University Hospital, Liverpool, UK., Ryder SD; NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust and the University of Nottingham, Queens Medical Centre, Nottingham, UK., Wright M; Department of Hepatology, University Hospital Southampton NHS Foundation Trust, Southampton, UK., Thursz M; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; The Liver Unit, St Mary's Hospital, London, UK., Vergis N; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; The Liver Unit, St Mary's Hospital, London, UK.; GSK, Brentford, UK.

Publikováno v: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2023 Dec; Vol. 58 (11-12), pp. 1217-1229. Date of Electronic Publication: 2023 Oct 02.

The diagnostic and prognostic significance of liver histology in alcoholic hepatitis

Autor: Forrest, E, Petts, G, Austin, A, Lloyd, K, Wright, M, Vergis, N, Atkinson, S, Masson, S, Patch, D, Quaglia, A, Thursz, M, Goldin, R

Background Liver biopsy may be of diagnostic and prognostic value but its role in alcoholic hepatitis (AH) has been controversial. Aim To assess the utility of liver biopsy in the assessment of clinically severe AH Methods The histological features o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::fe3f4d7a9185b381ae3cb9c385897328
http://hdl.handle.net/10044/1/85474

The Liverpool alcohol-related liver disease algorithm identifies twice as many emergency admissions compared to standard methods when applied to Hospital Episode Statistics for England.

Autor: Dhanda A; University of Plymouth, Plymouth, UK.; South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK., Bodger K; University of Liverpool, Liverpool, UK.; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Hood S; Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK., Henn C; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK., Allison M; Cambridge Liver Unit, Cambridge NIHR Biomedical Research Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Amasiatu C; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK., Burton R; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK., Cramp M; University of Plymouth, Plymouth, UK.; South West Liver Unit, University Hospitals Plymouth NHS Trust, Plymouth, UK., Forrest E; Glasgow Royal Infirmary, Glasgow, UK., Khetani M; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK., MacGilchrist A; Liver Unit, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Masson S; Liver Unit, Newcastle Hospitals NHS Trust, Newcastle, UK., Parker R; Leeds Liver Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Sheron N; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK., Simpson K; Liver Unit, Royal Infirmary of Edinburgh, NHS Lothian, Edinburgh, UK., Vergis N; Imperial College London, London, UK.; Research and Development, GlaxoSmithKline (GSK), Hertfordshire, UK., White M; Addiction and Inclusion Directorate, Office for Health Improvement and Disparities, Department for Health and Social Care, London, UK.

Publikováno v: Alimentary pharmacology & therapeutics [Aliment Pharmacol Ther] 2023 Feb; Vol. 57 (4), pp. 368-377. Date of Electronic Publication: 2022 Nov 17.