Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Vergil H. Ferm"'
Publikováno v:
Toxicology and Applied Pharmacology. 116:92-100
Exposure of semiconfluent cultures of Madin-Darby canine kidney cells to 10 microM zinc leads to a change in the organization of the actin filament system. Most of the stress fibers at the basal end of the cell are lost and the actin associated with
Autor:
Roger P. Smith, Vergil H. Ferm, Dean E. Wilcox, Harriet Kruszyna, Theodore R. Sana, Robert Kruszyna
Publikováno v:
Fundamental and Applied Toxicology. 15:754-759
Pairs of osmotic minipumps containing 400 mg/ml (6.15 m ) sodium azide in distilled water were subcutaneously implanted in timed pregnancy Syrian golden hamsters. The total delivered dose was calculated as 6 × 10 −2 mmol kg −1 hr −1 at the max
Autor:
THEODORE R. SANA, VERGIL H. FERM, ROGER P. SMITH, ROBERT KRUSZYNA, HARRIET KRUSZYNA, DEAN E. WILCOX
Publikováno v:
Toxicological Sciences. 15:754-759
Publikováno v:
Reproductive Toxicology. 4:183-190
Pregnant hamsters were treated with selenite, selenate, and selenomethionine during the critical stages of embryogenesis. The dosing regimens were oral, intravenous, and osmotic minipump infusion. Malformations, mainly encephaloceles, were noted with
Publikováno v:
Teratology. 42(4)
Inorganic selenium (Se) salts (selenite and selenate oxyanions) and the organic selenoamino acids (selenomethionine and seleniferous grains) are teratogenic and embryolethal in domestic and wild birds. Selenium bioaccumulation has been held responsib
Publikováno v:
Reproduction. 44:109-112
Manganese is an essential trace element in the living system. It is invariably present in its ionic form and is known to participate in a number of biological systems (Cotzias, 1958). Relatively high levels of manganese are required to manifest toxic
Publikováno v:
Toxicological Sciences. 4:977-982
Publikováno v:
Fundamental and Applied Toxicology. 3:41-48
Succinonitrile (SN) and tetramethylsuccinonitrile (TMSN) were evaluated and compared for their teratogenic potential. Groups of 3 to 20 pregnant hamsters received a single ip injection of either SN, at doses ranging from 0.78 to 6.24 mmol/kg, or TMSN
Autor:
David P. Hanlon, Vergil H. Ferm
Publikováno v:
Teratology. 34:189-193
Hamster dams dosed continuously with arsenate and exposed to short-term hyperthermia produced a greater percentage of malformed offspring than did hamster dams dosed with arsenate alone. Hamsters receiving both treatments possessed elevated arsenic c
Publikováno v:
Fundamental and Applied Toxicology. 4:977-982
Etretinate (Ro 10-9359; Tigason; 4-methoxy-2,3,6-trimethylphenyl analog of retinoic acid, ethyl ester) was evaluated for teratogenic activity in the Syrian golden hamster, Groups of pregnant hamsters were given a single oral dose of 2.8–88 mg/kg et