IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart.

Autor: Nanadikar, Maithily S., Vergel Leon, Ana M., Guo, Jia, van Belle, Gijsbert J., Jatho, Aline, Philip, Elvina S., Brandner, Astrid F., Böckmann, Rainer A., Shi, Runzhu, Zieseniss, Anke, Siemssen, Carla M., Dettmer, Katja, Brodesser, Susanne, Schmidtendorf, Marlen, Lee, Jingyun, Wu, Hanzhi, Furdui, Cristina M., Brandenburg, Sören, Burgoyne, Joseph R., Bogeski, Ivan

Publikováno v: Nature Communications; 4/14/2023, Vol. 14 Issue 1, p1-19, 19p

O 2 affects mitochondrial functionality ex vivo.

Autor: Nanadikar MS; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Vergel Leon AM; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Borowik S; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Hillemann A; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Zieseniss A; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Belousov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow 117997, Russia; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University Göttingen, Göttingen 37077, Germany; Pirogov Russian National Research Medical University, Moscow 117997, Russia., Bogeski I; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany., Rehling P; Department of Cellular Biochemistry, University Medical Center Göttingen, GZMB, 37077 Göttingen, Germany; Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany., Dudek J; Department of Cellular Biochemistry, University Medical Center Göttingen, GZMB, 37077 Göttingen, Germany; Comprehensive Heart Failure Center, CHFC, University Center Würzburg, Am Schwarzenberg 15, 97078 Würzburg, Germany., Katschinski DM; Institute for Cardiovascular Physiology, University Medical Center Göttingen, Georg-August-University, Humbdoltallee 23, 37077 Göttingen, Germany. Electronic address: doerthe.katschinski@med.uni-goettingen.de.

Publikováno v: Redox biology [Redox Biol] 2019 Apr; Vol. 22, pp. 101152. Date of Electronic Publication: 2019 Feb 23.