Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Verena Wenzl"'
Publikováno v:
Microorganisms, Vol 11, Iss 4, p 830 (2023)
Combination therapies appear to be beneficial for preventing bacterial resistance to antibacterial approaches. The aim of this study was to define and determine an optimal effective concentration combination (OPECC) for binary application of antibact
Externí odkaz:
https://doaj.org/article/b02ebaa30d634ff5bd6436e70ff60f3a
Autor:
Bernd Mayer, Cristina M. Furdui, Barbara S. Lang, Leslie B. Poole, M. Verena Wenzl, Gustav Oberdorfer, Karl Gruber, Antonius C.F. Gorren
Publikováno v:
Journal of Biological Chemistry. 287:38124-38134
Aldehyde dehydrogenase-2 (ALDH2) catalyzes the bioactivation of nitroglycerin (glyceryl trinitrate, GTN) in blood vessels, resulting in vasodilation by nitric oxide (NO) or a related species. Because the mechanism of this reaction is still unclear we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6fa50b2012a498b8c05d634e40c01a1
https://doi.org/10.1074/jbc.m112.371716
https://doi.org/10.1074/jbc.m112.371716
Autor:
Bernd Mayer, Matteo Beretta, Antonius C.F. Gorren, Doris Koesling, M. Verena Wenzl, Robert Weis, Michael Russwurm, Kurt Schmidt
Publikováno v:
The Journal of Biological Chemistry
The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase, and nitroglycerin (GTN) denitrating activities. The small molecule Alda-1 was reported to partly restore low acetaldehyde d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00617395f97e77a6cb04d882a822e587
https://doi.org/10.1074/jbc.m109.014548
https://doi.org/10.1074/jbc.m109.014548
Autor:
Karl Gruber, Antonius C.F. Gorren, Doris Koesling, Matteo Beretta, Pravas Kumar Baral, Andreas Zeller, Michael Russwurm, Kurt Schmidt, Bernd Mayer, M. Verena Wenzl
Publikováno v:
The Journal of Biological Chemistry
Mitochondrial aldehyde dehydrogenase-2 (ALDH2) plays an essential role in nitroglycerin (GTN) bioactivation, resulting in formation of NO or a related activator of soluble guanylate cyclase. ALDH2 denitrates GTN to 1,2-glyceryl dinitrate and nitrite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7927bb6c03283e344b6eea32be872f
https://doi.org/10.1074/jbc.m109.005652
https://doi.org/10.1074/jbc.m109.005652
Publikováno v:
Cardiovascular Research. 79:304-312
Aims Nitroglycerin (GTN) acts through release of a nitric oxide (NO)-related activator of soluble guanylate cyclase in vascular smooth muscle. Besides enzymatic GTN bioactivation catalysed by aldehyde dehydrogenase, non-enzymatic reaction of GTN with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6f276b0bb1f65bde0e2c5d94b9bbd9
https://doi.org/10.1093/cvr/cvn107
https://doi.org/10.1093/cvr/cvn107
Autor:
Barbara S, Lang, Antonius C F, Gorren, Gustav, Oberdorfer, M Verena, Wenzl, Cristina M, Furdui, Leslie B, Poole, Bernd, Mayer, Karl, Gruber
Publikováno v:
The Journal of Biological Chemistry
Background: Aldehyde dehydrogenase-2 (ALDH2) catalyzes bioactivation of glyceryl trinitrate (GTN) resulting in vasodilation. The exact mechanism is still unclear. Results: Structures of ALDH2 in complex with GTN and of a thionitrate intermediate were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c719cbdc2b6ae1c3ec3dfdd2bb81e9b
https://pubmed.ncbi.nlm.nih.gov/22988236
https://pubmed.ncbi.nlm.nih.gov/22988236
Autor:
Martina Griesberger, M. Verena Wenzl, Matteo Beretta, Alexander Kollau, Doris Koesling, Gerald Wölkart, Antonius C.F. Gorren, Bernd Mayer, Michael Russwurm, Kurt Schmidt
Publikováno v:
Molecular pharmacology. 79(3)
Mitochondrial aldehyde dehydrogenase (ALDH2) contributes to vascular bioactivation of the antianginal drugs nitroglycerin (GTN) and pentaerythrityl tetranitrate (PETN), resulting in cGMP-mediated vasodilation. Although continuous treatment with GTN r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b27c585f2c972739f713f6ed8deeeb09
https://pubmed.ncbi.nlm.nih.gov/21156756
https://pubmed.ncbi.nlm.nih.gov/21156756
Autor:
Matteo Beretta, Bernd Mayer, M. Verena Wenzl, Robert Weis, Doris Koesling, Antonius C.F. Gorren, Michael Russwurm, Kurt Schmidt
Publikováno v:
BMC Pharmacology
Background The East Asian variant of mitochondrial aldehyde dehydrogenase (ALDH2) exhibits significantly reduced dehydrogenase, esterase and nitroglycerin (GTN) reductase activities [1]. The small molecule Alda-1 was reported to partly restore low ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db65cc9cc51d0d026d990921accdb8ef
https://doi.org/10.1186/1471-2210-9-s2-a40
https://doi.org/10.1186/1471-2210-9-s2-a40
Autor:
Doris Koesling, Matteo Beretta, Andreas Zeller, Bernd Mayer, Heike Stessel, M. Verena Wenzl, Michael Russwurm, Kurt Schmidt
Publikováno v:
Molecular pharmacology. 76(5)
Nitroxyl (HNO) may be formed endogenously by uncoupled nitric-oxide (NO) synthases, enzymatic reduction of NO or as product of vascular nitroglycerin bioactivation. The established HNO donor Angeli's salt (trioxodinitrate, AS) causes cGMP-dependent v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1f770af3b9e86fd496ada4e5ec3445e
https://pubmed.ncbi.nlm.nih.gov/19720727
https://pubmed.ncbi.nlm.nih.gov/19720727
Autor:
Bernd Mayer, Matteo Beretta, Gerald Wölkart, Heike Stessl, Michaela Verena Wenzl, Kurt Schmidt
Publikováno v:
Nitric Oxide. 19:61-62
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea175712c7dced22ccf084e61db985ec
https://doi.org/10.1016/j.niox.2008.06.179
https://doi.org/10.1016/j.niox.2008.06.179