Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

Autor: Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson

Publikováno v: eLife, Vol 6 (2017)

To determine the dynamics of allelic-specific expression during mouse development, we analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also

Externí odkaz: https://doaj.org/article/56a76cb9f51a468ea09e84df56a0f1ab

Author Correction: The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression

Autor: Daniel Schramek, Athanassios Kotsinas, Arabella Meixner, Teiji Wada, Ulrich Elling, J. Andrew Pospisilik, G. Gregory Neely, Ralf-Harun Zwick, Verena Sigl, Guido Forni, Manuel Serrano, Vassilis G. Gorgoulis, Josef M. Penninger

Publikováno v: Nature Genetics. 55:891-891

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49c353ebb50857cf744acdbd05552eee
https://doi.org/10.1038/s41588-023-01387-x

RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy

Autor: Shane J. F. Cronin, Dagmar Bancher-Todesca, Magdalena Paolino, Jürgen Harreiter, Josef M. Penninger, Verena Sigl, Andrea J. White, Iris Uribesalgo, Georg A. Holländer, Lukas Kenner, Alexandra Kautzky-Willer, Esther Rauscher, Michael Schuster, Christoph Bock, Rubina Koglgruber, Thomas Penz, Blanka Pranjic, Juan Pablo Fededa, Maria Novatchkova, Graham Anderson, Sabine Dekan

Publikováno v: Nature

Successful pregnancies rely on adaptations within the mother1, including marked changes within the immune system2. It has long been known that the thymus, the central lymphoid organ, changes markedly during pregnancy3. However, the molecular basis an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4a0dfb4b7f9e9984544e32c5e2c4a3
https://europepmc.org/articles/PMC7116618/

RANKL/RANK control Brca1 mutation-driven mammary tumors

Autor: Miguel Angel Pujana, Kwadwo Owusu-Boaitey, Georg Pfeiler, Shuan Rao, Luigi Tortola, Melita Ticevic, Eva Y.-H. P. Lee, Enrique Vidal, Purna A. Joshi, Anoop Kavirayani, Daniel Schramek, Gerald Wirnsberger, Josef M. Penninger, Ashley A Odai-Afotey, Eva González-Suárez, Renu Sarao, Verena Sigl, Maria Novatchkova, for Cimba, Aishia Sampson, Iris Uribesalgo, Nnamdi Edokobi, Helmuth Popper, Lukas Kenner, Rama Khokha, Yen Y. Tan, Jennifer Cruickshank, Conxi Lázaro, Christian F. Singer, Zsuzsanna Bago-Horvath, Ivona Kozieradzki, Jerome Hersl, Holger Heyn, Hal K. Berman, Laundette P. Jones

Publikováno v: Cell Research
Sigl, V; Owusu-Boaitey, K; Joshi, PA; Kavirayani, A; Wirnsberger, G; Novatchkova, M; et al.(2016). RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research, 26(7), 761-774. doi: 10.1038/cr.2016.69. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/0bs3d6z8
Recercat. Dipósit de la Recerca de Catalunya
instname
Cell research, 26(7), 761-774. INST BIOCHEMISTRY & CELL BIOLOGY

© 2016 IBCB, SIBS, CAS All rights reserved. Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbd92993fa4237832179d864185f0a9
http://europepmc.org/articles/PMC5129883

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer

Autor: Daniel Branstetter, Manolo D’Arcangelo, Linnea La Fleur, Luigi Tortola, Shane J. F. Cronin, Josef M. Penninger, Verena Sigl, Michael Bergqvist, Roberto Nitsch, Lukas Kenner, Helmut Popper, Shuan Rao, Karolina Edlund, Stephan Handschuh, John M. Rossi, Simon Ekman, Reiner A. Wimmer, Alexander Jais, Astrid Hagelkruys, Ivona Kozieradzki, Thomas Lendl, Johan Botling, Maria Novatchkova, Jude Canon, Michael Orthofer, Gabriel Wagner, William C. Dougall, Fred R. Hirsch, Iris Uribesalgo, Hiroshi Takayanagi, Patrick Micke

Lung cancer is the leading cause of cancer deaths. Besides smoking, epidemiological studies have linked female sex hormones to lung cancer in women; however, the underlying mechanisms remain unclear. Here we report that the receptor activator of nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::358e7ca1b293d1faf19bebc8bfdbebef
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-342920