Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Verena Schuldenzucker"'
Autor:
Verena Schuldenzucker, Robin Schubert, Lisa M Muratori, Frauke Freisfeld, Lorena Rieke, Tamara Matheis, Sarah Schramke, Jan Motlik, Nicole Kemper, Ute Radespiel, Ralf Reilmann
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185970 (2017)
Large animal models of Huntington's disease (HD) may increase the reliability of translating preclinical findings to humans. Long live expectancy offers opportunities particularly for disease modifying approaches, but also challenges. The transgenic
Externí odkaz:
https://doaj.org/article/3cd3ab1d22f94713afea4989de5fa3be
Autor:
Lorena Rieke, Verena Schuldenzucker, Ralf Reilmann, Tamara Matheis, Michaela Fels, Benjamin Habbel, Nicole Kemper, Robin Schubert
Publikováno v:
Journal of Huntington's Disease. 8:23-31
Background To increase the reliability of translating preclinical findings to humans, large animal models, such as the transgenic (tg) Libechov minipig, were established. As minipigs possess high genetic homology with humans and have similarities in
Autor:
Robin Schubert, Jan Motlik, Sarah Schramke, Verena Schuldenzucker, Ralf Reilmann, Tamara Matheis, Frauke Freisfeld, Lisa M. Muratori, Nicole Kemper, Lorena Rieke, Ute Radespiel
Publikováno v:
Journal of Huntington's Disease. 7:151-161
BACKGROUND Huntington's disease (HD) is an autosomal-dominant, progressive neurodegenerative disorder with motor, cognitive, behavioral and metabolic symptoms. HD patients exhibit an altered response to stress which is reflected in changes of cortiso
Autor:
Jan Motlik, Stefanie Ott, Eun Young Kim, Ralf Reilmann, M Wirsig, Sarah Schramke, E Hölzner, Robin Schubert, Hans J. Johnson, Nina Nagelmann, Cornelius Faber, Verena Schuldenzucker, Frauke Frank, Lennart Liebsch, Sergej O. Demokritov
Publikováno v:
Journal of Neuroscience Methods. 265:46-55
Background As novel treatment approaches for Huntington's disease (HD) evolve, the use of transgenic (tg) large animal models has been considered for preclinical safety and efficacy assessments. It is hoped that large animal models may provide higher
Autor:
Robin Schubert, Ralf Reilmann, Frauke Frank, M Wirsig, Nicole Kemper, Michaela Fels, Sarah Schramke, Verena Schuldenzucker
Publikováno v:
Česká a slovenská neurologie a neurochirurgie. :55-60
Autor:
Lorena Rieke, Ralf Reilmann, Tamara Matheis, Benjamin Habbel, Verena Schuldenzucker, Robin Schubert
Publikováno v:
Models for HD.
Background Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical studies. Minipigs are characterise
Autor:
Tamara Matheis, Frauke Freisfeld, Michaela Fels, Robin Schubert, Ralf Reilmann, Jan Motlik, Verena Schuldenzucker, Nicole Kemper, Lisa M. Muratori, Lorena Rieke
Publikováno v:
Models for HD.
Backround Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical studies. Minipigs are characterised
Autor:
Sarah Schramke, Robin Schubert, Michaela Fels, Lorena Rieke, Ralf Reilmann, Tamara Matheis, Nicole Kemper, Lisa M. Muratori, Verena Schuldenzucker, Jan Motlik
Publikováno v:
Journal of Huntington's disease. 7(3)
BACKGROUND Large animal models, such as the transgenic (tg) Huntington disease (HD) minipig, have been proposed to improve translational reliability and assessment of safety, efficacy and tolerability in preclinical studies. Minipigs are characterise
Autor:
Ralf, Reilmann, Verena, Schuldenzucker
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1780
Large animal models offer novel opportunities in exploring safety, biology, and efficacy of novel therapeutic approaches for Huntington's disease (HD). Challenges in the development of, for example, gene therapy, such as delivery, distribution, and p
Autor:
Verena Schuldenzucker, Ralf Reilmann
Publikováno v:
Methods in Molecular Biology ISBN: 9781493978243
Large animal models offer novel opportunities in exploring safety, biology, and efficacy of novel therapeutic approaches for Huntington's disease (HD). Challenges in the development of, for example, gene therapy, such as delivery, distribution, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de839166f1a2984e7e263d73976cce98
https://doi.org/10.1007/978-1-4939-7825-0_13
https://doi.org/10.1007/978-1-4939-7825-0_13