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Matriptase-dependent epidermal pre-neoplasm in zebrafish embryos caused by a combination of hypotonic stress and epithelial polarity defects.

Autor: Julia Hatzold, Verena Nett, Stephanie Brantsch, Jin-Li Zhang, Joy Armistead, Heike Wessendorf, Rebecca Stephens, Patrick O Humbert, Sandra Iden, Matthias Hammerschmidt

Publikováno v: PLoS Genetics, Vol 19, Iss 8, p e1010873 (2023)

Aberrantly up-regulated activity of the type II transmembrane protease Matriptase-1 has been associated with the development and progression of a range of epithelial-derived carcinomas, and a variety of signaling pathways can mediate Matriptase-depen

Externí odkaz: https://doaj.org/article/72c70ea8bcc5480abbe1bc7b312005cd

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Human TRPV6-pathies caused by gene mutations

Autor: Amanda Wyatt, Verena Nett, Nicole Erhardt, Ulrich Wissenbach

Publikováno v: Biochimica et biophysica acta. General subjects. 1865(6)

The TRP-family of ion channels consists of 27 members in humans. Most TRP channels are non- selective cation channels with the exception of TRPV5 and TRPV6 which exhibit a high permeability for Ca2+ ions. A functional channel is formed by 4 identical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a8f373d01c8e43f018e3078bc454a
https://pubmed.ncbi.nlm.nih.gov/33610740

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