Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Verena Mutzel"'
Autor:
Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.
Externí odkaz:
https://doaj.org/article/fb6c9598aa694328ac2e4a2c1b16bd7b
Autor:
Edda G. Schulz, Ikuhiro Okamoto, Verena Mutzel, Luca Giorgetti, Ilona Dunkel, Edith Heard, Mitinori Saitou
Publikováno v:
Nature Structural and Molecular Biology
Nature Structural & Molecular Biology
Nature structural & molecular biology
Nature Structural & Molecular Biology
Nature structural & molecular biology
SummaryGene-regulatory networks control establishment and maintenance of alternative gene expression states during development. A particular challenge is the acquisition of opposing states by two copies of the same gene, as it is the case in mammals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9980e3c1be3dd7d22d93010d747bda4c
https://doi.org/10.1038/s41594-019-0214-1
https://doi.org/10.1038/s41594-019-0214-1
Autor:
Rutger A.F. Gjaltema, Till Schwämmle, Pauline Kautz, Michael Robson, Robert Schöpflin, Liat Ravid Lustig, Lennart Brandenburg, Ilona Dunkel, Carolina Vechiatto, Evgenia Ntini, Verena Mutzel, Vera Schmiedel, Annalisa Marsico, Stefan Mundlos, Edda G. Schulz
Publikováno v:
Mol. Cell 82, 190-208.e17 (2021)
Molecular Cell
Molecular Cell
Developmental genes such as Xist, which initiates X chromosome inactivation, are controlled by complex cis-regulatory landscapes, which decode multiple signals to establish specific spatiotemporal expression patterns. Xist integrates information on X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b361ead72a84f2a46ba323733c265e3
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63891
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63891
Autor:
Norbert Mages, Verena Mutzel, Annalisa Marsico, Ilona Dunkel, Bernd Timmermann, Edda G. Schulz, Guido Pacini
Publikováno v:
bioRxiv (The Preprintserver for biology)
To ensure dosage compensation between the sexes, one randomly chosen X chromosome is silenced in each female cell in the process of X-chromosome inactivation (XCI). XCI is initiated during early development through upregulation of the long non-coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::679c000e9e7db65c8b672c2ab4ff12e9
https://doi.org/10.1101/2020.07.20.211573
https://doi.org/10.1101/2020.07.20.211573
Autor:
Verena Mutzel, Edda G. Schulz
Publikováno v:
Bioessays
X-chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation. This process imposes a plethora of questions: How do cells count their X chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d586e94393c436ee23795e0694e88c
https://hdl.handle.net/21.11116/0000-0006-01A5-E21.11116/0000-0006-01A7-C
https://hdl.handle.net/21.11116/0000-0006-01A5-E21.11116/0000-0006-01A7-C