Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Verena Labi"'
Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity
Autor:
Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be eng
Externí odkaz:
https://doaj.org/article/019d4fb19cb64cd6834d48d84c0fafe0
Autor:
Christian Molnar, Sheila Bohler, Jovana Rajak, Julia Miriam Weiss, Irene Gonzalez-Mendez, Geoffroy Andrieux, Eva-Maria Demmerath, Madeleine Wahl, Lena Wendeburg, Gudrun Göhring, Brigitte Strahm, Doris Steinemann, Martina Rudelius, Melanie Börries, Leticia Quintanilla-Martinez, Charlotte M. Niemeyer, Verena Labi, Miriam Erlacher
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100069- (2023)
Externí odkaz:
https://doaj.org/article/eb53d0919a71441d88fd83a5986a697d
Autor:
Jeiny Luna Choconta, Verena Labi, Cristiana Dumbraveanu, Theodora Kalpachidou, Kai K. Kummer, Michaela Kress
Publikováno v:
Immunity & Ageing, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Pain in Fabry disease (FD) is generally accepted to result from neuronal damage in the peripheral nervous system as a consequence of excess lipid storage caused by alpha-galactosidase A (α-Gal A) deficiency. Signatures of pain arising from
Externí odkaz:
https://doaj.org/article/d7cfec8667fd48a0ac4476aea728779d
Autor:
Jiří Koutník, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier, Kerstin Siegmund
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background The Protein kinase D3 (PKD3) has been implicated in signal transduction downstream of the T cell receptor (TCR). However, its role for the activation of primary T lymphocytes has not been elucidated so far. Methods Expression of P
Externí odkaz:
https://doaj.org/article/d2cd8faf7d8a4d44a77535a25aa7c4b8
Autor:
Magdalena Hagen, Tirtha Chakraborty, William J. Olson, Martin Heitz, Natascha Hermann-Kleiter, Janine Kimpel, Brigitte Jenewein, Johanna Pertoll, Verena Labi, Klaus Rajewsky, Emmanuel Derudder
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B lymphocyte development proceeds through a well-ordered sequence of steps, leading to the formation of a sizeable mature B population recognizing a diversity of antigens. These latter cells are ultimately responsible for the production of antibodies
Externí odkaz:
https://doaj.org/article/571cedaed8154a859d7316d01c67d07c
Autor:
William J. Olson, Bojana Jakic, Verena Labi, Johannes Woelk, Emmanuel Derudder, Gottfried Baier, Natascha Hermann-Kleiter
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
B cells are key mediators of humoral immunity. Mature B cells fall into various sub-classes that can be separated by their ontogeny, expression of cell surface markers, anatomical location, and function. B1 subsets play important roles in natural imm
Externí odkaz:
https://doaj.org/article/e2139a73e90d43b3a56eebf28e146f74
Autor:
Bojana Jakic, William J. Olson, Kerstin Siegmund, Victoria Klepsch, Janine Kimpel, Verena Labi, Dietmar Zehn, Gottfried Baier, Natascha Hermann-Kleiter
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-16 (2021)
Abstract Memory formation is a hallmark of T cell-mediated immunity, but how differentiation into either short-lived effector cells (SLECs, CD127−KLRG1+) or memory precursors cells (MPECs, CD127+KLRG1−) and subsequent regulation of long-term memo
Externí odkaz:
https://doaj.org/article/16f2165276a045e28562fa2d8f16d12a
Publikováno v:
Bio-Protocol, Vol 11, Iss 23 (2021)
Pathogens such as bacteria, viruses, fungi, or protozoa can cause acute and chronic infections in their hosts. The intracellular bacterium Listeria monocytogenes serves as a model pathogen to assess the molecular mechanisms regulating CD8 T cell acti
Externí odkaz:
https://doaj.org/article/5ae1fc9d439c46d697278efc357e74a1
Autor:
Fabian Schuler, Johannes G. Weiss, Silke E. Lindner, Michael Lohmüller, Sebastian Herzog, Simon F. Spiegl, Philipp Menke, Stephan Geley, Verena Labi, Andreas Villunger
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Checkpoint kinase 1 (CHK1) is critical for intrinsic cell cycle control and coordination of cell cycle progression. Here the authors show that CHK1 loss or chemical inhibition impacts on normal B cell development, lymphomagenesis and cancer cell surv
Externí odkaz:
https://doaj.org/article/f516c8c11d6a41889865f546d8e29a09
Autor:
William J. Olson, Bojana Jakic, Verena Labi, Katia Schoeler, Michaela Kind, Victoria Klepsch, Gottfried Baier, Natascha Hermann-Kleiter
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2878-2891.e5 (2019)
Summary: CD4 T follicular helper (Tfh) cells are specialized in helping B cells during the germinal center (GC) reaction and ultimately promote long-term humoral immunity. Here we report that loss of the nuclear orphan receptor NR2F6 causes enhanced
Externí odkaz:
https://doaj.org/article/c6e258769d22419c911e8d6adc256291