AAV vectors for FRET-based analysis of protein-protein interactions in photoreceptor outer segments

Autor: Elvir Becirovic, Sybille Boehm, Ong Nam Phuong Nguyen, Lisa Maria Riedmayr, Verena Hammelmann, Christian Schön, Elisabeth Susanne Butz, Christian Wahl-Schott, Martin Biel, Stylianos Michalakis

Publikováno v: Frontiers in Neuroscience, Vol 10 (2016)

Fluorescence resonance energy transfer (FRET) is a powerful method for the detection and quantification of stationary and dynamic protein-protein interactions. Technical limitations have hampered systematic in vivo FRET experiments to study protein-p

Externí odkaz: https://doaj.org/article/e25e27f60a7446888c96eb0eef162a28

The retinitis pigmentosa mutation c.3444+1G>A in CNGB1 results in skipping of exon 32.

Autor: Elvir Becirovic, Kostadinka Nakova, Verena Hammelmann, Roman Hennel, Martin Biel, Stylianos Michalakis

Publikováno v: PLoS ONE, Vol 5, Iss 1, p e8969 (2010)

Retinitis pigmentosa (RP) is a severe hereditary eye disorder characterized by progressive degeneration of photoreceptors and subsequent loss of vision. Two of the RP associated mutations were found in the CNGB1 gene that encodes the B subunit of the

Externí odkaz: https://doaj.org/article/4347f29f96c744399b121612794f6aa9

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Autor: Chandy George, Israel Hanukoglu, Aguan D. Wei, Jane F. Armstrong, John A. Peters, Roslyn M. Bill, Steve A.N. Goldstein, Lucia G. Sivilotti, Mootaz M. Salman, Heike Wulff, Paul Davies, Michael Zhu, Stephan Kellenberger, Elena Faccenda, Michael F. Jarvis, Dejian Ren, Stefanie Fenske, Emma L. Veale, Jörg Striessnig, Verena Hammelmann, Brian F. King, Terrance P. Snutch, Trevor G. Smart, Leonard K. Kaczmarek, Brenda T. Winn, Eamonn Kelly, Philip Kitchen, Richard W. Aldrich, Jamie A. Davies, Charlotte Van den Eynde, Lachlan D. Rash, Edward Perez-Reyes, Elvir Becirovic, Christopher Southan, Joris Vriens, William A. Catterall, Jinbin Tian, Martin Biel, Adam J. Pawson, Leigh D. Plant, Alistair Mathie, Kotdaji Ha, James S. Trimmer, Bernard Attali, Anders A. Jensen, Lixia Yue, Joseph W. Lynch, Austin M. Baggetta, Haoxing Xu, Charles Kennedy, Xiaoli Zhang, Stephen P.H. Alexander, Simon D. Harding, Markus Delling, Simonetta Falzoni, Stephan Grissmer, Francesco Di Virgilio, Alex C. Conner

Publikováno v: British journal of pharmacology, vol. 178 Suppl 1, pp. S157-S245
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d921561f4575efc693e15cc0f59fd20
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf

Cyclic nucleotide-regulated channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Verena Hammelmann, U. Benjamin Kaupp, Elvir Becirovic, Franz Hofmann, Martin Biel

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2019

Cyclic nucleotide-gated (CNG) channels are responsible for signalling in the primary sensory cells of the vertebrate visual and olfactory systems.CNG channels are voltage-independent cation channels formed as tetramers. Each subunit has 6TM, with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31e6251558cb492ca2022e859f51dbbc
https://doi.org/10.2218/gtopdb/f71/2019.4

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect

Autor: Martin Biel, Stephan Kratzer, Corinna Mattusch, Claudia Kopp, Gerhard Rammes, Peter A. Goldstein, Eberhard Kochs, Martina Buerge, Tatiana Engel, Shui-Wang Ying, Rainer Haseneder, Matthias Kreuzer, Verena Hammelmann

Publikováno v: Anesthesiology. 122:1047-1059

Background: The thalamus is thought to be crucially involved in the anesthetic state. Here, we investigated the effect of the inhaled anesthetic xenon on stimulus-evoked thalamocortical network activity and on excitability of thalamocortical neurons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f3957f6437ea1a1395f9d39bf1851e7
https://doi.org/10.1097/aln.0000000000000635