Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice

Autor: Marc S. Stieglitz, Stefanie Fenske, Verena Hammelmann, Elvir Becirovic, Verena Schöttle, James E. Delorme, Martha Schöll-Weidinger, Robert Mader, Jan Deussing, David P. Wolfer, Mathias W. Seeliger, Urs Albrecht, Carsten T. Wotjak, Martin Biel, Stylianos Michalakis, Christian Wahl-Schott

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2018)

Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these

Externí odkaz: https://doaj.org/article/06a8cf2032ac4ed683c6dc858970939f

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Autor: Chandy George, Israel Hanukoglu, Aguan D. Wei, Jane F. Armstrong, John A. Peters, Roslyn M. Bill, Steve A.N. Goldstein, Lucia G. Sivilotti, Mootaz M. Salman, Heike Wulff, Paul Davies, Michael Zhu, Stephan Kellenberger, Elena Faccenda, Michael F. Jarvis, Dejian Ren, Stefanie Fenske, Emma L. Veale, Jörg Striessnig, Verena Hammelmann, Brian F. King, Terrance P. Snutch, Trevor G. Smart, Leonard K. Kaczmarek, Brenda T. Winn, Eamonn Kelly, Philip Kitchen, Richard W. Aldrich, Jamie A. Davies, Charlotte Van den Eynde, Lachlan D. Rash, Edward Perez-Reyes, Elvir Becirovic, Christopher Southan, Joris Vriens, William A. Catterall, Jinbin Tian, Martin Biel, Adam J. Pawson, Leigh D. Plant, Alistair Mathie, Kotdaji Ha, James S. Trimmer, Bernard Attali, Anders A. Jensen, Lixia Yue, Joseph W. Lynch, Austin M. Baggetta, Haoxing Xu, Charles Kennedy, Xiaoli Zhang, Stephen P.H. Alexander, Simon D. Harding, Markus Delling, Simonetta Falzoni, Stephan Grissmer, Francesco Di Virgilio, Alex C. Conner

Publikováno v: British journal of pharmacology, vol. 178 Suppl 1, pp. S157-S245
Alexander, S P, Mathie, A, Peters, J A, Veale, E L, Striessnig, J, Kelly, E, Armstrong, J F, Faccenda, E, Harding, S D, Pawson, A J, Southan, C, Davies, J A, Aldrich, R W, Attali, B, Baggetta, A M, Becirovic, E, Biel, M, Bill, R M, Catterall, W A, Conner, A C, Davies, P, Delling, M, Virgilio, F D, Falzoni, S, Fenske, S, George, C, Goldstein, S A N, Grissmer, S, Ha, K, Hammelmann, V, Hanukoglu, I, Jarvis, M, Jensen, A A, Kaczmarek, L K, Kellenberger, S, Kennedy, C, King, B, Kitchen, P, Lynch, J W, Perez-Reyes, E, Plant, L D, Rash, L, Ren, D, Salman, M M, Sivilotti, L G, Smart, T G, Snutch, T P, Tian, J, Trimmer, J S, Van den Eynde, C, Vriens, J, Wei, A D, Winn, B T, Wulff, H, Xu, H, Yue, L, Zhang, X & Zhu, M 2021, ' The concise guide to pharmacology 2021/22 : Ion channels ', British Journal of Pharmacology, vol. 178, no. Suppl. 1, pp. S157-S245 . https://doi.org/10.1111/bph.15539

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d921561f4575efc693e15cc0f59fd20
https://serval.unil.ch/resource/serval:BIB_8F1855C9FD25.P001/REF.pdf

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel.

Autor: Verena Hammelmann, Xiangang Zong, Franz Hofmann, Stylianos Michalakis, Martin Biel

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e17078 (2011)

Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 cha

Externí odkaz: https://doaj.org/article/890f27eb01af4b5984470361b9a59f43

Cyclic nucleotide-regulated channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

Autor: Verena Hammelmann, U. Benjamin Kaupp, Elvir Becirovic, Franz Hofmann, Martin Biel

Publikováno v: IUPHAR/BPS Guide to Pharmacology CITE. 2019

Cyclic nucleotide-gated (CNG) channels are responsible for signalling in the primary sensory cells of the vertebrate visual and olfactory systems.CNG channels are voltage-independent cation channels formed as tetramers. Each subunit has 6TM, with the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31e6251558cb492ca2022e859f51dbbc
https://doi.org/10.2218/gtopdb/f71/2019.4

Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect

Autor: Martin Biel, Stephan Kratzer, Corinna Mattusch, Claudia Kopp, Gerhard Rammes, Peter A. Goldstein, Eberhard Kochs, Martina Buerge, Tatiana Engel, Shui-Wang Ying, Rainer Haseneder, Matthias Kreuzer, Verena Hammelmann

Publikováno v: Anesthesiology. 122:1047-1059

Background: The thalamus is thought to be crucially involved in the anesthetic state. Here, we investigated the effect of the inhaled anesthetic xenon on stimulus-evoked thalamocortical network activity and on excitability of thalamocortical neurons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5f3957f6437ea1a1395f9d39bf1851e7
https://doi.org/10.1097/aln.0000000000000635