Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Verena Grunow"'
Autor:
Stefanie Koidl, Astrid Sobke, Klaus T. Preissner, Peter Vajkoczy, Marion Scharpfenecker, Simone Rosseau, Nicholas W. Gale, Norbert Suttorp, Hellmut G. Augustin, Matthias Herrmann, Yvonne Reiss, Martin Witzenrath, Gavin Thurston, Ulrike Fiedler, Verena Grunow
Publikováno v:
Nature Medicine. 12:235-239
The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine kinase Tie-2 (refs. 1,2). Paracrine Ang-1-mediated activation of Tie-2 acts as a regulator of vessel maturation and vascular quiescence. In turn, the antagonis
Autor:
Ulrike Fiedler, Verena Grunow, Stefanie Koidl, Gavin Thurston, Anja Hegen, Marion Scharpfenecker, Jarno M. Schmidt, Wilhelm Kriz, Hellmut G. Augustin
Publikováno v:
Blood. 103(11)
The angiopoietins Ang-1 and Ang-2 have been identified as ligands with opposing functions of the receptor tyrosine kinase Tie-2 regulating endothelial cell survival and vascular maturation. Ang-1 acts in a paracrine agonistic manner, whereas Ang-2 ap