Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Verena Gotta"'
Autor:
Tatjana Welzel, Klervi Golhen, Andrew Atkinson, Verena Gotta, David Ternant, Jasmin B. Kuemmerle-Deschner, Christine Michler, Gilbert Koch, Johannes N. van den Anker, Marc Pfister, Andreas Woerner
Publikováno v:
Pediatric Rheumatology Online Journal, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background In pediatric rheumatic diseases (PRD), adalimumab is dosed using fixed weight-based bands irrespective of methotrexate co-treatment, disease activity (DA) or other factors that might influence adalimumab pharmacokinetics (PK). In
Externí odkaz:
https://doaj.org/article/f2c51365bcf44787aa48f649528e7736
Autor:
Klervi Golhen, Michael Buettcher, Jörg Huwyler, John van den Anker, Verena Gotta, Kim Dao, Laura E. Rothuizen, Kevin Kobylinski, Marc Pfister
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1186 (2024)
The antiparasitic drug ivermectin is approved for persons > 15 kg in the US and EU. A pharmacometric (PMX) population model with clinical PK data was developed (i) to characterize the effect of the patient-friendly ivermectin formulation CHILD-IVITAB
Externí odkaz:
https://doaj.org/article/12e1f1321610492b84aa70d719982c48
Autor:
Verena Gotta, Julia Anna Bielicki, Paolo Paioni, Chantal Csajka, Dominic Stefan Bräm, Christoph Berger, Elisabeth Giger, Michael Buettcher, Klara M. Posfay-Barbe, John van den Anker, Marc Pfister
Publikováno v:
Swiss Medical Weekly, Vol 154, Iss 4 (2024)
BACKGROUND AND AIMS: Pharmacometric in silico approaches are frequently applied to guide decisions concerning dosage regimes during the development of new medicines. We aimed to demonstrate how such pharmacometric modelling and simulation can provide
Externí odkaz:
https://doaj.org/article/1e2536a16ca447fea78a789062ead18b
Autor:
Anica Fenner, Melanie Huber, Verena Gotta, Vera Jaeggi, Luregn J. Schlapbach, Philipp Baumann
Publikováno v:
Children, Vol 11, Iss 6, p 731 (2024)
Antibiotic overtreatment fosters multidrug-resistance that threatens healthcare systems worldwide as it increases patient morbidity and mortality. Contemporary data on antibiotic usage on tertiary care paediatric intensive care units for in- and exte
Externí odkaz:
https://doaj.org/article/8dfa1f7f509141348858e3dbbcabf7c6
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 207-220 (2023)
Abstract Diabetic ketoacidosis (DKA), a frequent complication of type 1 diabetes (T1D), is characterized by hyperosmolar hypovolemia. The response of water‐regulating hormones arginine vasopressin (AVP; antidiuretic hormone) and aldosterone to DKA
Externí odkaz:
https://doaj.org/article/99c58f0f7700484d8b4fa19c3d811bb6
Autor:
Britta Steffens, Gilbert Koch, Pascal Gächter, Fabien Claude, Verena Gotta, Freya Bachmann, Johannes Schropp, Marco Janner, Dagmar l'Allemand, Daniel Konrad, Tatjana Welzel, Gabor Szinnai, Marc Pfister
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesGraves' disease (GD) with onset in childhood or adolescence is a rare disease (ORPHA:525731). Current pharmacotherapeutic approaches use antithyroid drugs, such as carbimazole, as monotherapy or in combination with thyroxine hormone substit
Externí odkaz:
https://doaj.org/article/c3e9c3811567474e91030811eae525aa
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1081 (2023)
Imatinib is a targeted cancer therapy that has significantly improved the care of patients with chronic myeloid leukemia (CML) and gastrointestinal stromal tumor (GIST). However, it has been shown that the recommended dosages of imatinib are associat
Externí odkaz:
https://doaj.org/article/c16005e152ce45049eef7c6700f01b38
Publikováno v:
Frontiers in Pediatrics, Vol 10 (2022)
ObjectivesThe objective of this pharmacometric (PMX) study was to (i) characterize population pharmacokinetics (PPK) and exposure-pain response associations following intranasal (0.1 mg/kg) or intravenous (IV, 0.05 mg/kg) administration of nalbuphine
Externí odkaz:
https://doaj.org/article/d87e652c8ced4c8088024ebbffc20938
Autor:
Philipp Baumann, Aline Fuchs, Verena Gotta, Nicole Ritz, Gurli Baer, Jessica M. Bonhoeffer, Michael Buettcher, Ulrich Heininger, Gabor Szinnai, Jan Bonhoeffer, for the ProPAED study group
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Background Kinetics of copeptin and mid regional proadrenomedullin (MR-proADM) during febrile pediatric lower respiratory tract infections (LRTI) are unknown. We aimed to analyze kinetic profiles of copeptin and MR-proADM and the impact of clinical a
Externí odkaz:
https://doaj.org/article/c624e61ce27647c980876f59f1913425
Autor:
Philipp Baumann, Verena Gotta, Andrew Atkinson, Markus Deisenberg, Martin Hersberger, Adam Roggia, Kevin Schmid, Vincenzo Cannizzaro
Publikováno v:
Children, Vol 9, Iss 6, p 794 (2022)
Low copeptin levels may indicate inadequate arginine-vasopressin release promoting arterial hypotension, whereas high copeptin concentrations may reflect disease severity. This single-center prospective non-randomized clinical trial analyzed the cour
Externí odkaz:
https://doaj.org/article/721bc32c12bf437fa79de3ec5a619fdb