Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Verena Gobel"'
Publikováno v:
Biological Reviews. 97:251-272
Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite, functioning as a signalling molecule in diverse cellular processes. Over the past few decades, studies of S1P signalling have revealed that the physiological activity of S1P largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc17f96d7164d3f1c6d761ef6a4ebba1
https://doi.org/10.1111/brv.12798
https://doi.org/10.1111/brv.12798
In prevailing epithelial polarity models, membrane-based polarity cues such as the partitioning-defective PARs specify the positions and identities of apicobasal membrane domains. Recent findings suggest, however, that vesicle-associated polarity cue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f01dbdf4854623c5bc6e81f6a9c15f1a
https://doi.org/10.1101/2022.02.06.479326
https://doi.org/10.1101/2022.02.06.479326
Autor:
Nan Zhang, Hongjie Zhang, Liakot A Khan, Gholamali Jafari, Yong Eun, Edward Membreno, Verena Gobel
In prevailing epithelial polarity models, membrane-based polarity cues (e.g., the partitioning-defective PARs) position apicobasal cellular membrane domains. Intracellular vesicular trafficking expands these domains by sorting apicobasal cargo toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1961bb72abc84762de8071c3476cea9
https://doi.org/10.1101/2022.01.06.475118
https://doi.org/10.1101/2022.01.06.475118
Autor:
Hongjie Zhang, Gholamali Jafari, Liakot A. Khan, Verena Gobel, Edward Membreno, Siyang Yan, Nan Zhang
Publikováno v:
The Journal of Cell Biology
Unicellular tubes, components of organs and capillaries, form intracellular lumens. Khan et al. report that a tensile triple intermediate-filament lattice, embedded between microfilaments and microtubules, tunnels the lumen through the single-cell C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e5a91c807030daa757369a1ab833f0
http://europepmc.org/articles/PMC6605810
http://europepmc.org/articles/PMC6605810
Autor:
Kin Yip Tam, Anbing Shi, Bin Liang, Xuanjun Zhang, Hongjie Zhang, Verena Gobel, Rong Ying, Xue Jiang, Mengqiao Cui, Jun Zheng, Gang Li
Publikováno v:
The Journal of Neuroscience. 39:5816-5834
Hereditary sensory and autonomic neuropathy Type 1 (HSAN1) is a rare autosomal dominantly inherited neuropathy, clinically characterized by a loss of distal peripheral sensory and motoneuronal function. Mutations in subunits of serine palmitoyltransf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae5c7f1c290cf56782cad2121ee9df7
https://doi.org/10.1523/jneurosci.2541-18.2019
https://doi.org/10.1523/jneurosci.2541-18.2019
Publikováno v:
Biochemical and Biophysical Research Communications. 505:600-605
RAB-11/Rab11 is an endosomal GTPase with conserved roles in directional trafficking and apical domain formation in polarized epithelial cells. From a yeast two-hybrid screen using full-length C. elegans RAB-11 as bait, we identified LEC-5 as a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4cf87e73cfb819d3dc7c4587ca9fd6
https://doi.org/10.1016/j.bbrc.2018.09.110
https://doi.org/10.1016/j.bbrc.2018.09.110
Publikováno v:
Biological Reviews. 93:1438-1460
As a prevalent post-translational modification, ubiquitination is essential for many developmental processes. Once covalently attached to the small and conserved polypeptide ubiquitin (Ub), a substrate protein can be directed to perform specific biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ba725c8b7cd3e4cf7551f44ab11b1f
https://doi.org/10.1111/brv.12404
https://doi.org/10.1111/brv.12404
Autor:
Verena Gobel, Hongjie Zhang, Siyang Yan, Gholamali Jafari, Edward Membreno, Liakot A Khan, Nan Zhang
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90f79c30311fd2c1b1b0570df0a44b57
https://doi.org/10.3791/56100-v
https://doi.org/10.3791/56100-v
Publikováno v:
Journal of Visualized Experiments.
The four C. elegans excretory canals are narrow tubes extended through the length of the animal from a single cell, with almost equally far extended intracellular endotubes that build and stabilize the lumen with a membrane and submembraneous cytoske
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a94288a794af20c0a95c556a5cb32b
https://doi.org/10.3791/56101
https://doi.org/10.3791/56101
Autor:
Verena Gobel, Siyang Yan, Nan Zhang, Gholamali Jafari, Edward Membreno, Hongjie Zhang, Liakot A. Khan
Publikováno v:
Journal of Visualized Experiments.
Multicellular tubes, fundamental units of all internal organs, are composed of polarized epithelial or endothelial cells, with apical membranes lining the lumen and basolateral membranes contacting each other and/or the extracellular matrix. How this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9023367ba4717e675bd50f720f5024c3
https://doi.org/10.3791/56100
https://doi.org/10.3791/56100