Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Verena Boschert"'
Autor:
Verena Boschert, Johannes Boenke, Ann-Kathrin Böhm, Jonas Teusch, Valentin Steinacker, Anton Straub, Stefan Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7334 (2024)
Although inhibitors targeting the PD1/PD-L1 immune checkpoint are showing comparably good outcomes, a significant percentage of head and neck squamous cell carcinoma (HNSCC) patients do not respond to treatment. Apart from using different treatment s
Externí odkaz:
https://doaj.org/article/049e1cc5fc4e4a1aaa8910918a7007ee
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 775 (2022)
The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational mod
Externí odkaz:
https://doaj.org/article/0d2f84aa051c4d7789f5d00f9d474a0b
Autor:
Verena Boschert, Jonas Teusch, Anwar Aljasem, Philipp Schmucker, Nicola Klenk, Anton Straub, Max Bittrich, Axel Seher, Christian Linz, Urs D. A. Müller-Richter, Stefan Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8770 (2020)
Head and neck squamous cell carcinoma (HNSCC) is a widespread disease with a low survival rate and a high risk of recurrence. Nowadays, immune checkpoint inhibitor (ICI) treatment is approved for HNSCC as a first-line treatment in recurrent and metas
Externí odkaz:
https://doaj.org/article/8044eb9612ad4cdf80438c2edb5c916d
Autor:
Verena Boschert, Nicola Klenk, Alexander Abt, Sudha Janaki Raman, Markus Fischer, Roman C. Brands, Axel Seher, Christian Linz, Urs D. A. Müller-Richter, Thorsten Bischler, Stefan Hartmann
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 2, p 471 (2020)
Head and neck squamous cell carcinoma (HNSCC) is known to overexpress a variety of receptor tyrosine kinases, such as the HGF receptor Met. Like other malignancies, HNSCC involves a mutual interaction between the tumor cells and surrounding tissues a
Externí odkaz:
https://doaj.org/article/cade972cde004f18919cf02eb044ef0e
Autor:
Verena Boschert, Maarten van Dinther, Stella Weidauer, Katharina van Pee, Eva-Maria Muth, Peter ten Dijke, Thomas D. Mueller
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/70ed4decf88046ff9d702b59d1e70283
Autor:
Maarten van Dinther, Juan Zhang, Stella E Weidauer, Verena Boschert, Eva-Maria Muth, Achim Knappik, David J J de Gorter, Puck B van Kasteren, Christian Frisch, Thomas D Mueller, Peter ten Dijke
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62295 (2013)
Sclerosteosis is a rare high bone mass disease that is caused by inactivating mutations in the SOST gene. Its gene product, Sclerostin, is a key negative regulator of bone formation and might therefore serve as a target for the anabolic treatment of
Externí odkaz:
https://doaj.org/article/f9a0fd8880214c629ade8f4eb736a565
Autor:
Verena Boschert, Maarten van Dinther, Stella Weidauer, Katharina van Pee, Eva-Maria Muth, Peter Ten Dijke, Thomas D Mueller
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e81710 (2013)
The cystine-knot containing protein Sclerostin is an important negative regulator of bone growth and therefore represents a promising therapeutic target. It exerts its biological task by inhibiting the Wnt (wingless and int1) signaling pathway, which
Externí odkaz:
https://doaj.org/article/a228ee4bb24a4ece9007e486537ddd70
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:388-392
The secreted cystine-knot protein sclerostin was first identified from genetic screening of patients suffering from the rare bone-overgrowth diseases sclerosteosis and van Buchem disease. Sclerostin acts a negative regulator of bone growth through in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70553cc770e9f916ec53bc37eab6c65f
https://doi.org/10.1107/s2053230x1500360x
https://doi.org/10.1107/s2053230x1500360x
Autor:
Achim Knappik, Stella E. Weidauer, J. W. Back, Monika Beerbaum, Eva-Maria Muth, Thomas D. Mueller, Peter Schmieder, K. van Pee, Verena Boschert, Peter Timmerman, Christian Frisch
Publikováno v:
Open Biology, Vol 6, Iss 8 (2016)
Open biology, 6(8):160120
Open Biology
Open biology, 6(8):160120
Open Biology
The glycoprotein sclerostin has been identified as a negative regulator of bone growth. It exerts its function by interacting with the Wnt co-receptor LRP5/6, blocks the binding of Wnt factors and thereby inhibits Wnt signalling. Neutralizing anti-sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46acbedb0e10d4a8ab7bcc9b4a53bc57
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17792
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/17792
Autor:
Verena Boschert, Maarten van Dinther, Stella Weidauer, Katharina van Pee, Eva-Maria Muth, Peter ten Dijke, Thomas D. Mueller
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 1 (2014)
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2bb51ce955cbc50614a5b82de0bcdeb
http://europepmc.org/articles/PMC3882281
http://europepmc.org/articles/PMC3882281