Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Verena Apfel"'
Autor:
Melusine Bleu, Fanny Mermet-Meillon, Verena Apfel, Louise Barys, Laura Holzer, Marianne Bachmann Salvy, Rui Lopes, Inês Amorim Monteiro Barbosa, Cecile Delmas, Alexandra Hinniger, Suzanne Chau, Markus Kaufmann, Simon Haenni, Karolin Berneiser, Maria Wahle, Ivana Moravec, Alexandra Vissières, Tania Poetsch, Erik Ahrné, Nathalie Carte, Johannes Voshol, Elisabeth Bechter, Jacques Hamon, Marco Meyerhofer, Dirk Erdmann, Matteo Fischer, Therese Stachyra, Felix Freuler, Sascha Gutmann, César Fernández, Tobias Schmelzle, Ulrike Naumann, Guglielmo Roma, Kate Lawrenson, Cristina Nieto-Oberhuber, Amanda Cobos-Correa, Stephane Ferretti, Dirk Schübeler, Giorgio Giacomo Galli
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Lineage-restricted transcription factor PAX8 is oncogenic in ovarian cancer cells. Here the authors show that PAX8 interacts and recruits a splice variant of the MECOM locus PRDM3 to control the gene expression module involved in adhesion and extrace
Externí odkaz:
https://doaj.org/article/e459f346777c48fab385e6b2235f6c4c
Autor:
Melusine Bleu, Swann Gaulis, Rui Lopes, Kathleen Sprouffske, Verena Apfel, Sjoerd Holwerda, Marco Pregnolato, Umut Yildiz, Valentina Cordoʹ, Antonella F. M. Dost, Judith Knehr, Walter Carbone, Felix Lohmann, Charles Y. Lin, James E. Bradner, Audrey Kauffmann, Luca Tordella, Guglielmo Roma, Giorgio G. Galli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Transcription factors are critical regulators of cell identity. Here, the authors use computational and functional genomic approaches to show an oncogenic role of PAX8 in renal cancer. Mechanistic dissection of PAX8 functions reveal its role in activ
Externí odkaz:
https://doaj.org/article/a841cd70bc974e82bf6c4f6bbe42719f
Autor:
Ulrike Naumann, David A. Ruddy, Debora Bonenfant, Valentina Cordo, Stephane Ferretti, Andreas Weiss, Verena Apfel, Ines Barbosa, Alexandra Buhles, Reinaldo Almeida, Grainne Kerr, Damien Begue, Laetitia Martinuzzi, Giorgio G. Galli, Luca Tordella, Michelle Piquet, Laura Holzer
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Asparagine deprivation by l-asparaginase (L-ASNase) is an effective therapeutic strategy in acute lymphoblastic leukemia, with resistance occurring due to upregulation of ASNS, the only human enzyme synthetizing asparagine (Annu. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4617fa9d1331f299416bc9bfec2b576
https://doi.org/10.1021/acsptsci.0c00196
https://doi.org/10.1021/acsptsci.0c00196
Autor:
Judith Knehr, James E. Bradner, Charles Y. Lin, Valentina Cordoʹ, Audrey Kauffmann, Kathleen Sprouffske, Guglielmo Roma, Walter Carbone, Swann Gaulis, Giorgio G. Galli, Antonella F M Dost, Luca Tordella, Rui Lopes, Melusine Bleu, Umut Yildiz, Marco Pregnolato, Felix Lohmann, Verena Apfel, Sjoerd J B Holwerda
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
Transcription factor networks shape the gene expression programs responsible for normal cell identity and pathogenic state. Using Core Regulatory Circuitry analysis (CRC), we identify PAX8 as a candidate oncogene in Renal Cell Carcinoma (RCC) cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec6739b6b5497bf507aec40cac2435d
http://link.springer.com/article/10.1038/s41467-019-11672-1
http://link.springer.com/article/10.1038/s41467-019-11672-1
Autor:
David E. Root, Clary B. Clish, Mahmoud Ghandi, William R. Sellers, Verena Apfel, Kerry A. Pierce, William C. Hahn, Shuba Gopal, Raymond Pagliarini, Dojna Shkoza, Shaoyang Ning, Francisca Vazquez, Aviad Tsherniak, Levi A. Garraway, Stuart L. Schreiber, Amanda Souza, Amy Deik, Yilong Zou, Marios Giannakis, Gregory V. Kryukov, Julie Ann, Paula Keskula, Giorgio G. Galli, Haoxin Li, Desiree Hernandez, Jordi Barretina
Publikováno v:
Nature Medicine. 25:850-860
Despite considerable efforts to identify cancer metabolic alterations that might unveil druggable vulnerabilities, systematic characterizations of metabolism as it relates to functional genomic features and associated dependencies remain uncommon. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::980f500fd90efe8bb919bee7bfe0bea3
https://doi.org/10.1038/s41591-019-0404-8
https://doi.org/10.1038/s41591-019-0404-8
Autor:
Juan Diaz-Miyar, Antoine deWeck, Marc Altorfer, Guglielmo Roma, Annick Waldt, Fanny Mermet-Meillon, Ulrike Naumann, Rok Krese, Rachel Cuttat, Mathias Eder, Joachim Weischenfeldt, Rui Lopes, André Vidas Olsen, Simon Wengert, Walter Carbone, Esther C. H. Uijttewaal, Verena Apfel, Adriana Emma Wesdorp, Kathleen Sprouffske, Dirk Schübeler, Giorgio G. Galli, Audrey Kauffmann, Philipp S. Hoppe, Jan Dahinden, Melusine Bleu, Umut Yildiz, Judith Knehr, Caibin Sheng
Publikováno v:
Lopes, R, Sprouffske, K, Sheng, C, Uijttewaal, E C H, Wesdorp, A E, Dahinden, J, Wengert, S, Diaz-Miyar, J, Yildiz, U, Bleu, M, Apfel, V, Mermet-Meillon, F, Krese, R, Eder, M, Olsen, A V, Hoppe, P, Knehr, J, Carbone, W, Cuttat, R, Waldt, A, Altorfer, M, Naumann, U, Weischenfeldt, J, deWeck, A, Kauffmann, A, Roma, G, Schübeler, D & Galli, G G 2021, ' Systematic dissection of transcriptional regulatory networks by genome-scale and single-cell CRISPR screens ', Science Advances, vol. 7, no. 27, eabf5733 . https://doi.org/10.1126/sciadv.abf5733
Millions of putative transcriptional regulatory elements (TREs) have been cataloged in the human genome, yet their functional relevance in specific pathophysiological settings remains to be determined. This is critical to understand how oncogenic tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d2f8984b1f3f9701761e7abc615195
https://curis.ku.dk/portal/da/publications/systematic-dissection-of-transcriptional-regulatory-networks-by-genomescale-and-singlecell-crispr-screens(22df3d06-0c32-449b-8fc4-303d9a1dae35).html
https://curis.ku.dk/portal/da/publications/systematic-dissection-of-transcriptional-regulatory-networks-by-genomescale-and-singlecell-crispr-screens(22df3d06-0c32-449b-8fc4-303d9a1dae35).html
Autor:
Johannes Voshol, Therese Stachyra, Alexandra Vissieres, Elisabeth Bechter, Verena Apfel, Erik Ahrné, Maria Wahle, Suzanne Chau, Ivana Moravec, Karolin Fiona Berneiser, Nathalie Carte, Tania Poetsch, Rui Lopes, Dirk Schübeler, Simon Haenni, Markus Kaufmann, Stephane Ferretti, Dirk Erdmann, Alexandra Hinniger, Marianne Bachmann Salvy, Jacques Hamon, Guglielmo Roma, Amanda Cobos-Correa, Ulrike Naumann, César Fernández, Louise Barys, Cristina Nieto-Oberhuber, Giorgio G. Galli, Melusine Bleu, Matteo Fischer, Felix Freuler, Sascha Gutmann, Kate Lawrenson, Fanny Mermet-Meillon, Tobias Schmelzle, Cecile Delmas, Laura Holzer, Marco Meyerhofer, Ines Barbosa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal and ovarian cancers. While a plethora of PAX8-regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aaf78d1de96ff3b8d6880ccacc7215a
https://pubmed.ncbi.nlm.nih.gov/33903593
https://pubmed.ncbi.nlm.nih.gov/33903593
Autor:
Stephanie Valeaux, Juan Zhang, Rainer Kneuer, Janet Dawson, Saijel Patel, Tina Rubic-Schneider, Tobias Junt, Perrine Loesle, Sophie Sarret, Nina Gommermann, Bruno Tigani, José M. Carballido, Verena Apfel, Amanda Littlewood-Evans, Alban Muller
Publikováno v:
The Journal of Experimental Medicine
Littlewood-Evans et al. demonstrate that extracellular succinate leads to the propagation of inflammatory macrophage activation, providing translational evidence to support the development of GPR91 antagonists for the treatment of rheumatoid arthriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e29df82da3188d4f888540015f1c86
https://doi.org/10.1084/jem.20160061
https://doi.org/10.1084/jem.20160061