Longitudinal analyses of CLL in mice identify leukemia-related clonal changes including a Myc gain predicting poor outcome in patients

Autor: Sascha Dietrich, Irene Gil-Farina, Selcen Öztürk, Marc Zapatka, Peter Lichter, Lavinia Arseni, Manfred Schmidt, Bola S. Hanna, Philipp M. Roessner, Anna Jauch, Stephan Stilgenbauer, Peter-Martin Bruch, Saira Afzal, Yashna Paul, Martina Seiffert, Verena Kalter

Publikováno v: Leukemia

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy mainly occurring at an advanced age with no single major genetic driver. Transgenic expression of TCL1 in B cells leads after a long latency to a CLL-like disease in aged Eµ-TCL1 mice suggest

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be562e2e6a735f38acc00cd848da34c2
http://europepmc.org/articles/PMC8807396

Nitrogen loss processes in response to upwelling in a Peruvian coastal setting dominated by denitrification – a mesocosm approach

Autor: Tim Boxhammer, Andrea Ludwig, Lennart T. Bach, Bess B. Ward, Isabel Baños, Maricarmen Igarza, Javier Arístegui, Carolin R. Löscher, Fabrizio Minutolo, Ulf Riebesell, Dirk V. Erler, Elisabeth von der Esch, Judith Meyer, Eric P. Achterberg, Verena Kalter, Kai G. Schulz, Jana Meyer

Publikováno v: Schulz, K G, Achterberg, E P, Arístegui, J, Bach, L T, Baños, I, Boxhammer, T, Erler, D, Igarza, M, Kalter, V, Ludwig, A, Löscher, C, Meyer, J, Meyer, J, Minutolo, F, Von Der Esch, E, Ward, B B & Riebesell, U 2021, ' Nitrogen loss processes in response to upwelling in a Peruviancoastal setting dominated by denitrification : a mesocosm approach ', Biogeosciences, vol. 18, no. 14, pp. 4305-4320 . https://doi.org/10.5194/bg-18-4305-2021
Biogeosciences
Biogeosciences, Vol 18, Pp 4305-4320 (2021)

Upwelling of nutrient-rich deep waters make eastern boundary upwelling systems (EBUSs), such as the Humboldt Current system, hot spots of marine productivity. Associated settling of organic matter to depth and consecutive aerobic decomposition result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9585bc244132c4644c84d8c5ce5f0d6f
https://bg.copernicus.org/articles/18/4305/2021/

IDO1-Targeted Therapy Does Not Control Disease Development in the Eµ-TCL1 Mouse Model of Chronic Lymphocytic Leukemia

Autor: Murat Sunbul, Martina Seiffert, Verena Kalter, Philipp M. Roessner, Selcen Öztürk

Publikováno v: Cancers
Volume 13
Issue 8
Cancers, Vol 13, Iss 1899, p 1899 (2021)

Simple Summary The tryptophan-catabolizing enzyme IDO1 and its metabolite kynurenine were shown to be enhanced in patients with chronic lymphocytic leukemia (CLL), and their involvement in T cell suppression and immune escape was suggested. As we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1b54185855ad737c80147d8b8addc5
https://pubmed.ncbi.nlm.nih.gov/33920868

Interleukin-10 receptor signaling promotes the maintenance of a PD-1

Autor: Bola S, Hanna, Laura, Llaó-Cid, Murat, Iskar, Philipp M, Roessner, Lara C, Klett, John K L, Wong, Yashna, Paul, Nikolaos, Ioannou, Selcen, Öztürk, Norman, Mack, Verena, Kalter, Dolors, Colomer, Elías, Campo, Johannes, Bloehdorn, Stephan, Stilgenbauer, Sascha, Dietrich, Manfred, Schmidt, Richard, Gabriel, Karsten, Rippe, Markus, Feuerer, Alan G, Ramsay, Peter, Lichter, Marc, Zapatka, Martina, Seiffert

Publikováno v: Immunity. 54(12)

T cell exhaustion limits anti-tumor immunity and responses to immunotherapy. Here, we explored the microenvironmental signals regulating T cell exhaustion using a model of chronic lymphocytic leukemia (CLL). Single-cell analyses identified a subset o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e7d083f208fa077095390dc49708bdbd
https://pubmed.ncbi.nlm.nih.gov/34879221

Factors controlling plankton productivity, particulate matter stoichiometry, and export fluxin the coastal upwelling system off Peru

Autor: Carsten Spisla, Mathias Haunost, Nauzet Hernández-Hernández, Mabel Zavala Moreira, Alba Filella, Jesus Ledesma, Eric P. Achterberg, Jonna Piiparinen, Tim Boxhammer, Anne Sophie Boegeholz, Francisco P. Chavez, Christian Lieberum, Paulina Aguayo, Javier Arístegui, Jana Meyer, Patricia Grasse, Avy Bernales, Allanah J. Paul, Fabrizio Minutolo, Sonia Sánchez, Leila Kittu, Ulf Riebesell, Mark J. Hopwood, Michael Sswat, Joaquin Ortiz Cortes, Elisabeth von der Esch, Michelle Graco, Ursula Mendoza, Judith Meyer, Andrea Ludwig, Maricarmen Igarza, Verena Kalter, Martin A. Fischer, Isabel Baños, Claudia Sforna, Patrizia Ayon, Carolin Loescher, Peter Kohnert, Shao-Min Chen, Lennart T. Bach, Kristian Spilling, Kristin Doering, Silke Lischka, Kai G. Schulz, Jan Hennke

Eastern boundary upwelling systems (EBUS) are among the most productive marine ecosystems on Earth. The high productivity in surface waters is facilitated by upwelling of nutrient-rich deep waters, with high light availability enabling fast phytoplan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088c77e2cd4e9749c6256ea35bfc4a70
https://doi.org/10.5194/bg-2020-35