Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vered Katz Ben-Yair"'
Autor:
Faizal Z. Asumda, Nellie A. Campbell, Mohamed A. Hassan, Reza Fathi, Daniella F. Vasquez Rico, Melanie Kiem, Ethan V. Vang, Yo Han Kim, Xin Luo, Daniel R. O’Brien, Sarah A. Buhrow, Joel M. Reid, Michael J. Moore, Vered Katz Ben-Yair, Mark L. Levitt, Jennifer L. Leiting, Amro M. Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J. Truty, Lewis R. Roberts
Publikováno v:
Cancers, Vol 16, Iss 5, p 1050 (2024)
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancer
Externí odkaz:
https://doaj.org/article/b28f6e53a90c47cf8ff9a1d3118f22b6
Effect of Opaganib on Supplemental Oxygen and Mortality in Patients with Severe SARS-CoV-2 Pneumonia
Autor:
Fernando Carvalho Neuenschwander, Ofra Barnett-Griness, Stefania Piconi, Yasmin Maor, Eduardo Sprinz, Nimer Assy, Oleg Khmelnitskiy, Nikita Lomakin, Boris Mikhailovich Goloshchekin, Ewelina Nahorecka, Adilson Joaquim Westheimer Calvacante, Anastasia Ivanova, Sergey Vladimirovich Zhuravel, Galina Yurevna Trufanova, Stefano Bonora, Amer Saffoury, Ami Mayo, Yury Shvarts, Giuliano Rizzardini, Rogerio Sobroza de Mello, Janaina Pilau, Alexey Klinov, Benjamin Valente-Acosta, Oleg Olegovich Burlaka, Natalia Bakhtina, Maskit Bar-Meir, Ivan Nikolaevich Shishimorov, Jose Oñate-Gutierrez, Cristian Ivan Garcia Rincon, Tatiana Ivanovna Martynenko, Ludhmila Abrahão Hajjar, Ana Carolina Nazare de Mendonca Procopio, Krzystof Simon, Walter Gabriel Chaves Santiago, Adam Fronczak, Conrado Roberto Hoffmann Filho, Osama Hussein, Vladimir Aleksandrovich Martynov, Guido Chichino, Piotr Blewaska, Jacek Wroblewski, Sergio Saul Irizar Santana, Andres Felipe Ocampo Agudelo, Adam Barczyk, Rachael L. Gerlach, Eppie Campbell, Aida Bibliowicz, Reza Fathi, Patricia Anderson, Gilead Raday, Michal Klein, Clara Fehrmann, Gina Eagle, Vered Katz Ben-Yair, Mark L. Levitt
RationaleThere are few treatment options for severe COVID-19 pneumonia. Opaganib is an oral treatment under investigation.ObjectiveEvaluate opaganib treatment in hospitalized patients with severe COVID-19 pneumonia.MethodsA randomized, placebo-contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac5a8655eb260c38557cc88d09eaf63c
https://doi.org/10.1101/2022.06.12.22276088
https://doi.org/10.1101/2022.06.12.22276088
Autor:
Yubin Kang, Pasupathi Sundaramoorthy, Cristina Gasparetto, Daniel Feinberg, Shengjun Fan, Gwynn Long, Emily Sellars, Anderson Garrett, Sascha A. Tuchman, Brandi N. Reeves, Zhiguo Li, Bei Liu, Besim Ogretmen, Lynn Maines, Vered Katz Ben-Yair, Charles Smith, Terry Plasse
Publikováno v:
Annals of hematologyReferences.
Multiple myeloma (MM) remains an incurable disease and there is an unmet medical need for novel therapeutic drugs that do not share similar mechanisms of action with currently available agents. Sphingosine kinase 2 (SK2) is an innovative molecular ta
Autor:
Kevin L, Winthrop, Alan W, Skolnick, Adnan M, Rafiq, Scott H, Beegle, Julian, Suszanski, Guenther, Koehne, Ofra, Barnett-Griness, Aida, Bibliowicz, Reza, Fathi, Patricia, Anderson, Gilead, Raday, Gina, Eagle, Vered Katz, Ben-Yair, Harold S, Minkowitz, Mark L, Levitt, Michael S, Gordon
Publikováno v:
Open Forum Infectious Diseases. 9
Background Opaganib, an oral sphingosine kinase-2 inhibitor with antiviral and anti-inflammatory properties, was shown to inhibit severe acute respiratory syndrome coronavirus 2 replication in vitro. We thus considered that opaganib could be benefici
Autor:
Charles D Smith, Lynn W Maines, Staci N Keller, Vered Katz Ben-Yair, Reza Fathi, Terry F Plasse, Mark L Levitt
Publikováno v:
Drug design, development and therapy. 16
The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive humanitarian and economic stress across the world. Although antivirals active against mild disease have been identified recently, new drugs to treat moderate and severe
Autor:
Scott Beegle, Alan W Skolnick, Mark L. Levitt, Michael S Gordon, Patricia Anderson, Harold S Minkowitz, Gina Eagle, Guenther Koehne, Gilead Raday, Kevin L. Winthrop, Adnan Rafiq, Reza Fathi, Aida Bibliowicz, Ofra Barnett-Griness, Vered Katz Ben-Yair, Julian Suszanski
BackgroundOpaganib, an oral sphingosine kinase-2 inhibitor with antiviral and anti-inflammatory properties, was shown to inhibit SARS-CoV-2 replication in vitro. We thus considered that opaganib could be beneficial for moderate to severe COVID-19 pne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11367e9baa18250ae680554587c233e6
https://doi.org/10.1101/2021.08.23.21262464
https://doi.org/10.1101/2021.08.23.21262464
Autor:
Marja Talikka, Julia Hoeng, Karsta Luettich, Justyna Szostak, Manuel C. Peitsch, Brett Fields, Jennifer Park, Vered Katz Ben-Yair, Anita R. Iskandar, Ulrike Kogel, Shay Rotkopf, Yang Xiang, Walter K. Schlage
Publikováno v:
Cancer Research. 75:B1-19
Over the past few years, we constructed a number of biological network models representing comprehensive connectivity maps of fundamental molecular mechanisms regulating cell proliferation, cellular stress, and cell fate in the healthy and inflamed l
Autor:
Yo Han Kim, Lewis R. Roberts, Jennifer L. Leiting, Nellie A. Campbell, Sarah A. Buhrow, Daniel R. O'Brien, Faizal Z. Asumda, Joel M. Reid, Mark L. Levitt, Mohamed A. Hassan, Michael J. Moore, Reza Fathi, Mark J. Truty, Vered Katz Ben-Yair, Xin Luo, Fabrice Lucien-Matteoni
Publikováno v:
Cancer Research. 80:3078-3078
Background: Upamostat is an orally available small molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2 and trypsin 3 (PRSS1/2/3) as well as urokinase-type plasminogen activator (uPA) which are expressed in man