Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus

Autor: Martina Mijušković, Yi-Fan Chou, Vered Gigi, Cory R. Lindsay, Olga Shestova, Susanna M. Lewis, David B. Roth

Publikováno v: Cell Reports, Vol 12, Iss 11, Pp 1842-1852 (2015)

Genome-wide analysis of thymic lymphomas from Tp53−/− mice with wild-type or C-terminally truncated Rag2 revealed numerous off-target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected on

Externí odkaz: https://doaj.org/article/f6fe3566d1774424a350b2d0e590a3e5

RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of 'alternative NHEJ'

Autor: Vered Gigi, Martina Mijušković, Wenzhao Meng, David Roth, Eline T. Luning Prak, Ludovic Deriano, Susanna M. Lewis, Olga Shestova

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2014, 42 (10), pp.6352-64. ⟨10.1093/nar/gku295⟩
Nucleic Acids Research, 2014, 42 (10), pp.6352-64. ⟨10.1093/nar/gku295⟩

International audience; DNA double-stranded breaks (DSBs) can be repaired by several mechanisms, including classical NHEJ (c-NHEJ) and a poorly defined, error-prone process termed alternative NHEJ (a-NHEJ). How cells choose between these alternatives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670ca871dc27dd795c7ad156b3b7801e
https://hal-pasteur.archives-ouvertes.fr/pasteur-01471690/file/gku295.pdf