Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Vered Bronner"'
Autor:
Vered Bronner, Keren Sinik, Alona Goor, Maya Haus-Cohen, Yael Elbaz, Yoav Pizem, Raanan Greenman, Shai S. Shen-Orr, Galit Denkberg, Anat Levin, Guy Horev, Yoram Reiter, Galit Horn
Publikováno v:
Molecular cancer therapeutics. 20(5)
Chimeric antigen receptors (CARs) are immunoreceptors that redirect T cells to selectively kill tumor cells. Given their clinical successes in hematologic malignancies, there is a strong aspiration to advance this immunotherapy for solid cancers; hen
Publikováno v:
Journal of Biological Chemistry. 287:14659-14671
Substrates tagged with (poly)ubiquitin for degradation can be targeted directly to the 26 S proteasome where they are proteolyzed. Independently, ubiquitin conjugates may also be delivered by bivalent shuttles. The majority of shuttles attach to the
Publikováno v:
Label-Free Technologies for Drug Discovery
Autor:
Rina Barak, Orna Liarzi, Monica Dines, Michael Eisenbach, Vered Bronner, Alla Shainskaya, Yael Sagi
Publikováno v:
Molecular Microbiology. 76:932-943
Summary The ability of CheY, the response regulator of bacterial chemotaxis, to generate clockwise rotation is regulated by two covalent modifications – phosphorylation and acetylation. While the function and signal propagation of the former are wi
Autor:
Yulia Matiuhin, Vered Bronner, Daoning Zhang, David Fushman, Michael H. Glickman, Tony Y. Chen, Rina Rosenzweig, Inbal Ziv
Publikováno v:
Molecular Cell. 36(6):1018-1033
As a signal for substrate targeting, polyubiquitin meets various layers of receptors upstream to the 26S proteasome. We obtained structural information on two receptors, Rpn10 and Dsk2, alone, and in complex with (poly)ubiquitin or with each other. A
Publikováno v:
Cellular and Molecular Bioengineering. 1:216-228
Surface plasmon resonance (SPR) technology is a central, widely used tool for kinetic studies of interactions between unlabeled biomolecules in real time. The ProteOn XPR36 protein interaction array system possesses all the qualities of high-level SP
Autor:
Laetitia Rubrecht, Tsafrir Bravman, Daniel Laune, Oded Nahshol, Vered Bronner, Ariel G. Notcovich
Publikováno v:
Analytical Biochemistry. 383:52-60
The production of antibodies for diagnostic and therapeutic applications is a major focus for biotechnology and pharmaceutical companies, and it requires the development of fast, high-throughput methodologies for screening and selecting appropriate c
Autor:
Mario Lebendiker, Tsafrir Bravman, Hadar Refaely, Stefan G.D. Rüdiger, Chen Katz, Deborah E. Shalev, Assaf Friedler, Monica Dines, Tsafi Danieli, Anat Iosub, Shahar Rotem, Hadar Benyamini, Vered Bronner
Publikováno v:
Proceedings of the National Academy of Sciences. 105:12277-12282
We have characterized the molecular basis of the interaction between ASPP2 and Bcl-2, which are key proteins in the apoptotic pathway. The C-terminal ankyrin repeats and SH3 domain of ASPP2 (ASPP2 Ank-SH3 ) mediate its interactions with the antiapopt
Autor:
Efrat Zahavi, Galit Denkberg, Vered Bronner, Yoram Reiter, Yael Elbaz, Tsafrir Bravman, Ariel G. Notcovich, Mira Peled, Harel Kasoto
Publikováno v:
Analytical biochemistry. 406(2)
Therapeutic monoclonal antibodies are becoming a significant and rapidly growing class of therapeutic pharmaceuticals. Their discovery and development requires fast and high-throughput methodologies for screening and selecting appropriate candidate a
Autor:
Orna, Liarzi, Rina, Barak, Vered, Bronner, Monica, Dines, Yael, Sagi, Alla, Shainskaya, Michael, Eisenbach
Publikováno v:
Molecular microbiology. 76(4)
The ability of CheY, the response regulator of bacterial chemotaxis, to generate clockwise rotation is regulated by two covalent modifications - phosphorylation and acetylation. While the function and signal propagation of the former are widely under