Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

Autor: Avraham Maimon, Maxim Mogilevsky, Asaf Shilo, Regina Golan-Gerstl, Akram Obiedat, Vered Ben-Hur, Ilana Lebenthal-Loinger, Ilan Stein, Reuven Reich, Jonah Beenstock, Eldar Zehorai, Claus L. Andersen, Kasper Thorsen, Torben F. Ørntoft, Roger J. Davis, Ben Davidson, David Mu, Rotem Karni

Publikováno v: Cell Reports, Vol 7, Iss 2, Pp 501-513 (2014)

Summary: The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively spliced yielding two splicing isoforms with differing last exons: M

Externí odkaz: https://doaj.org/article/bf0775f207b84a6085b0d57af787b01d

Inhibition of nonsense-mediated mRNA decay may improve stop codon read-through therapy for Duchenne muscular dystrophy

Autor: Adi Amar-Schwartz, Yuval Cohen, Antony Elhaj, Vered Ben-Hur, Zahava Siegfried, Rotem Karni, Talya Dor

Publikováno v: Human Molecular Genetics.

Duchene muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are genetic neuromuscular disorders that affect skeletal and cardiac muscle resulting from mutations in the dystrophin gene (DMD), coding for dystrophin protein. Read-through therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81aa19b78aa7874f7098d0b8290f417f
https://doi.org/10.1093/hmg/ddad072

Author response: S6K1 phosphorylates Cdk1 and MSH6 to regulate DNA repair

Autor: Amina Jbara, Vered Ben Hur, Adi Amar-Schwartz, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e55bb2a4203611f05b120af888d5423
https://doi.org/10.7554/elife.79128.sa2

Mnk2 Alternative Splicing Modulates the p38-MAPK Pathway and Impacts Ras-Induced Transformation

Autor: David Mu, Asaf Shilo, Torben F. Ørntoft, Reuven Reich, Ben Davidson, Rotem Karni, Ilana Lebenthal-Loinger, Jonah Beenstock, Eldar Zehorai, Kasper Thorsen, Ilan Stein, Maxim Mogilevsky, Akram Obiedat, Regina Golan-Gerstl, Roger J. Davis, Vered Ben-Hur, Claus L. Andersen, Avraham Maimon

Publikováno v: Cell Reports, Vol 7, Iss 2, Pp 501-513 (2014)
Maimon, A, Mogilevsky, M, Shilo, A, Golan-Gerstl, R, Obiedat, A, Ben-Hur, V, Lebenthal-Loinger, I, Stein, I, Reich, R, Beenstock, J, Zehorai, E, Andersen, C L, Thorsen, K, Orntoft, T F, Davis, R J, Davidson, B, Mu, D & Karni, R 2014, ' Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation ', Cell Reports, vol. 7, no. 2, pp. 501-13 . https://doi.org/10.1016/j.celrep.2014.03.041

Summary: The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively spliced yielding two splicing isoforms with differing last exons: M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::177ba359876ab28735b5612e489a6281
https://doi.org/10.1016/j.celrep.2014.03.041

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

Autor: Noa Weinberg-Corem, Miri Stolovich-Rain, Ann Saada, Frances M. Ashcroft, Yuval Dor, Daniela Dadon, Benjamin Glaser, Vered Ben-Hur, Shay Porat, Ayat Hija, Peter White, Zvi Granot, Rotem Karni, Christophe Girard, Joseph Grimsby, Rachel Schyr-Ben-Haroush, Sharona Tornovsky-Babaey, Mark A. Magnuson, Klaus H. Kaestner

Publikováno v: Cell Metabolism
Cell Metabolism, Elsevier, 2011, 13 (4), pp.440-449. ⟨10.1016/j.cmet.2011.02.012⟩
Cell Metabolism; Vol 13

SummaryRecent studies revealed a surprising regenerative capacity of insulin-producing β cells in mice, suggesting that regenerative therapy for human diabetes could in principle be achieved. Physiologic β cell regeneration under stressed condition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af93a46a12bd053f5bc841fb37ec017c