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Cu2+-Induced self-assembly and amyloid formation of a cyclic d,l-α-peptide: structure and function

Autor: Daniel Klose, Sahithya Phani Babu Vemulapalli, Michal Richman, Safra Rudnick, Vered Aisha, Meital Abayev, Marina Chemerovski, Meital Shviro, David Zitoun, Katharina Majer, Nino Wili, Gil Goobes, Christian Griesinger, Gunnar Jeschke, Shai Rahimipour

Publikováno v: Physical Chemistry Chemical Physics

In a wide spectrum of neurodegenerative diseases, self-assembly of pathogenic proteins to cytotoxic intermediates is accelerated by the presence of metal ions such as Cu2+. Only low concentrations of these early transient oligomeric intermediates are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1469e44000de7eade745e36691f3e65c
https://doi.org/10.1039/d1cp05415e

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Autor: Daniel, Klose, Sahithya Phani Babu, Vemulapalli, Michal, Richman, Safra, Rudnick, Vered, Aisha, Meital, Abayev, Marina, Chemerovski, Meital, Shviro, David, Zitoun, Katharina, Majer, Nino, Wili, Gil, Goobes, Christian, Griesinger, Gunnar, Jeschke, Shai, Rahimipour

Publikováno v: Physical chemistry chemical physics : PCCP. 24(11)

In a wide spectrum of neurodegenerative diseases, self-assembly of pathogenic proteins to cytotoxic intermediates is accelerated by the presence of metal ions such as Cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d92ae20792957d15b32f530aeaac3c8b
https://pubmed.ncbi.nlm.nih.gov/35234757

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Multifunctional cyclic D,L-α-peptide architectures stimulate non-insulin dependent glucose uptake in skeletal muscle cells and protect them against oxidative stress

Autor: Vered Aisha, Bareket Daniel, Safra Rudnick, Renana Shapira, Arie Gruzman, Alex Perelman, Olga Viskind, Michal Richman, Shai Rahimipour, Jordan H. Chill, Kamesh R. Ayasolla

Publikováno v: Journal of medicinal chemistry. 56(17)

Oxidative stress directly correlates with the early onset of vascular complications and the progression of peripheral insulin resistance in diabetes. Accordingly, exogenous antioxidants augment insulin sensitivity in type 2 diabetic patients and amel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::068b34678109e13061c38f14e36c756c
https://pubmed.ncbi.nlm.nih.gov/23984871

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