Evolution of substrate specificity in a retained enzyme driven by gene loss.

Autor: Juárez-Vázquez AL; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico., Edirisinghe JN; Computing, Environment and Life Sciences Directorate, Argonne National Laboratory, Lemont, United States.; Computation Institute, University of Chicago, Chicago., Verduzco-Castro EA; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico., Michalska K; Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Lemont, United States.; Structural Biology Center, Biosciences Division, Argonne National Laboratory, Lemont, United States., Wu C; Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, United States., Noda-García L; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico., Babnigg G; Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Lemont, United States., Endres M; Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Lemont, United States., Medina-Ruíz S; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico., Santoyo-Flores J; Cinvestav-IPN, , Mexico., Carrillo-Tripp M; Cinvestav-IPN, , Mexico., Ton-That H; Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, United States., Joachimiak A; Midwest Center for Structural Genomics, Biosciences Division, Argonne National Laboratory, Lemont, United States.; Department of Microbiology and Molecular Genetics, University of Texas Health Science Center, Houston, United States.; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, United States., Henry CS; Computing, Environment and Life Sciences Directorate, Argonne National Laboratory, Lemont, United States.; Computation Institute, University of Chicago, Chicago., Barona-Gómez F; Evolution of Metabolic Diversity Laboratory, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Irapuato, Mexico.

Publikováno v: ELife [Elife] 2017 Mar 31; Vol. 6. Date of Electronic Publication: 2017 Mar 31.

Insights into the evolution of enzyme substrate promiscuity after the discovery of (βα)₈ isomerase evolutionary intermediates from a diverse metagenome.

Autor: Noda-García L; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. lianet.noda@weizmann.ac.il.; Current Addresses: Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel. lianet.noda@weizmann.ac.il., Juárez-Vázquez AL; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. ajuarez@langebio.cinvestav.mx., Ávila-Arcos MC; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. mavila2@stanford.edu.; Current Addresses: Department of Genetics, Stanford University, Stanford, CA, USA. mavila2@stanford.edu., Verduzco-Castro EA; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. everduzco@langebio.cinvestav.mx., Montero-Morán G; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. gabriela.montero@ipicyt.edu.mx.; Current Addresses: División de Biología Molecular, Instituto Potosino de Investigación Científica y Tecnológica, San Luis Potosí, México. gabriela.montero@ipicyt.edu.mx., Gaytán P; Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 2001, CP 62250, Cuernavaca, México. paul@ibt.unam.mx., Carrillo-Tripp M; Biomolecular Diversity Laboratories, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. trippm@langebio.cinvestav.mx., Barona-Gómez F; Evolution of Metabolic Diversity, Unidad de Genómica Avanzada (Langebio), Cinvestav-IPN, Km 9.6 Libramiento Norte, Carretera Irapuato - León, CP 36821, Irapuato, México. fbarona@langebio.cinvestav.mx.

Publikováno v: BMC evolutionary biology [BMC Evol Biol] 2015 Jun 10; Vol. 15, pp. 107. Date of Electronic Publication: 2015 Jun 10.