Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Verdonck Marc Gustaaf Celine"'
Autor:
Christopher John Love, Jean-Paul R.M.A. Bosmans, Verdonck Marc Gustaaf Celine, Luc Moens, Jef Cuypers, Michel J.A. De Cleyn, Harrie J.M. Gijsen, Michel Surkyn, Sven Franciscus Anna Janssen Pharm. Van Brandt
Publikováno v:
Tetrahedron. 64:2456-2464
Two diastereoselective, scaleable routes towards trans -3,4-disubstituted piperidines with a 4-hydroxymethyl-3-hydroxy or 4-aminomethyl-3-hydroxy substitution pattern are being described. In the first route, the 3,4-trans configuration was introduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4aeb8e6fe77a066ee76c252c31d549
https://doi.org/10.1016/j.tet.2007.12.055
https://doi.org/10.1016/j.tet.2007.12.055
Autor:
Peter ten Holte, Boudewijn Janssens, Sandrine Gaurrand, Janine Arts, Jacky van Gompel, Virginie Sophie Poncelet, Patrick Angibaud, Ann Marien, Hans De Winter, Bruno Roux, An Aerts, Verdonck Marc Gustaaf Celine, Jacky Van Dun, Luc Van Hijfte, Kristof Van Emelen, Isabelle Noëlle Constance Pilatte, Eddy Jean Edgard Freyne, Wim Floren, Michel Janicot, Sven Franciscus Anna Van Brandt, Jean-Michel Argoullon, Laurence Queguiner
Publikováno v:
European Journal of Medicinal Chemistry. 40:597-606
A series of pyrimidyl-5-hydroxamic acids was prepared for evaluation as inhibitors of histone deacetylase (HDAC). Amino-2-pyrimidinyl can be used as a linker to provide HDAC inhibitors of good enzymatic potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abdbd08dce8f647012c95f1517777f59
https://doi.org/10.1016/j.ejmech.2005.01.008
https://doi.org/10.1016/j.ejmech.2005.01.008
Autor:
Bruno Roux, Luc Van Hijfte, Jacky van Gompel, Claire Mackie, Sven Franciscus Anna Janssen Pharm. Van Brandt, Marc Noppe, Ann Marien, David Speybrouck, Lut Janssen, Marc Du Jardin, Wim Floren, Eddy Jean Edgard Freyne, Michel Janicot, Kristof Van Emelen, Jacky Van Dun, Ron Gilissen, Isabelle Noëlle Constance Pilatte, Virginie Sophie Poncelet, Patrick Angibaud, Verdonck Marc Gustaaf Celine, Peter ten Holte, Sandrine Gaurrand, Martin John Page, Jozef Peeters, Laurence Decrane, Janine Arts, Laurence Queguiner
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(1)
Pursuing our efforts in designing 5-pyrimidylhydroxamic acid anti-cancer agents, we have identified a new series of potent histone deacetylase (HDAC) inhibitors. These compounds exhibit enzymatic HDAC inhibiting properties with IC(50) values in the n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc639d3fe98001df6eb7f54901be8937
https://pubmed.ncbi.nlm.nih.gov/19906529
https://pubmed.ncbi.nlm.nih.gov/19906529