Current challenges and improvements in assessing the immunogenicity of bacterial vaccines.

Autor: Fantoni G; VisMederi S.r.l., Siena, Italy.; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy., Boccadifuoco G; VisMederi S.r.l., Siena, Italy., Verdirosa F; VisMederi S.r.l., Siena, Italy., Molesti E; VisMederi S.r.l., Siena, Italy., Manenti A; VisMederi S.r.l., Siena, Italy., Montomoli E; VisMederi S.r.l., Siena, Italy.; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2024 Jul 09; Vol. 15, pp. 1404637. Date of Electronic Publication: 2024 Jul 09 (Print Publication: 2024).

Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria.

Autor: Bersani M; Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Failla M; Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Vascon F; Department of Biology, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy., Gianquinto E; Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Bertarini L; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy., Baroni M; Kinetic Business Centre, Molecular Discovery Ltd., Elstree, Borehamwood, Hertfordshire WD6 4PJ, UK., Cruciani G; Department of Chemistry, Biology and Biotechnology, Università Degli Studi di Perugia, Via Elce di Sotto, 06132 Perugia, Italy., Verdirosa F; Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100 Siena, Italy., Sannio F; Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100 Siena, Italy., Docquier JD; Department of Medical Biotechnologies, University of Siena, Viale Bracci 16, 53100 Siena, Italy.; Laboratoire de Bactériologie Moléculaire, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000 Liège, Belgium., Cendron L; Department of Biology, University of Padua, Viale G. Colombo 3, 35121 Padua, Italy., Spyrakis F; Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Lazzarato L; Department of Drug Science and Technology, University of Turin, Via Pietro Giuria 9, 10125 Turin, Italy., Tondi D; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125 Modena, Italy.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Dec 02; Vol. 16 (12). Date of Electronic Publication: 2023 Dec 02.

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases

Autor: Spyrakis, F., Santucci, M., Maso, L., Cross, S., Gianquinto, E., Sannio, F., Verdirosa, F., De Luca, F., Docquier, J. D., Cendron, L., Tondi, D., Venturelli, A., Cruciani, G., Costi, M. P.

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports

Bacteria are known to evade β-lactam antibiotic action by producing β-lactamases (BLs), including carbapenemases, which are able to hydrolyze nearly all available β-lactams. The production of BLs represents one of the best known and most targeted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3d2df6d839d4d9d64aa45da7bfc66f04
http://link.springer.com/article/10.1038/s41598-020-69431-y

Zidovudine-β-Lactam Pronucleoside Strategy for Selective Delivery into Gram-Negative Bacteria Triggered by β-Lactamases.

Autor: Rosales-Hurtado M; Institut des Biomolécules Max Mousseron, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Sannio F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy., Lari L; Institut des Biomolécules Max Mousseron, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Verdirosa F; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy., Feller G; Laboratoire de Biochimie, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000 Liège, Belgium., Carretero E; Institut des Biomolécules Max Mousseron, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France., Vo-Hoang Y; HSM, Univ Montpellier, CNRS, IRD, CHU Montpellier, 34090 Montpellier, France., Licznar-Fajardo P; HSM, Univ Montpellier, CNRS, IRD, CHU Montpellier, 34090 Montpellier, France., Docquier JD; Dipartimento di Biotecnologie Mediche, Università di Siena, I-53100 Siena, Italy.; Laboratoire de Bactériologie Moléculaire, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000 Liège, Belgium., Gavara L; Institut des Biomolécules Max Mousseron, Univ Montpellier, CNRS, ENSCM, 34293 Montpellier, France.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2023 Aug 11; Vol. 9 (8), pp. 1546-1557. Date of Electronic Publication: 2023 Jul 13.

Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.

Autor: Legru A; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France., Verdirosa F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy., Vo-Hoang Y; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France., Tassone G; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy., Vascon F; Laboratory of Structural Biology, Department of Biology, University of Padua, 35121 Padova, Italy., Thomas CA; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Sannio F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy., Corsica G; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy., Benvenuti M; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy., Feller G; Laboratoire de Biochimie, Centre d'Ingénierie des Protéines-InBioS, Université de Liège, Allée du 6 août B6, Sart-Tilman, B-4000 Liège, Belgium., Coulon R; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France., Marcoccia F; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy., Devente SR; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy., Bouajila E; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France., Piveteau C; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France., Leroux F; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France., Deprez-Poulain R; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France., Deprez B; Drugs and Molecules for Living System, U1177, Inserm, Université de Lille, Faculté de Pharmacie, 59006 Lille, France., Licznar-Fajardo P; HydroSciences Montpellier, UMR5151, Univ Montpellier, CNRS, IRD, CHU Montpellier, 34000 Montpellier, France., Crowder MW; Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States., Cendron L; Laboratory of Structural Biology, Department of Biology, University of Padua, 35121 Padova, Italy., Pozzi C; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy., Mangani S; Dipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, 53100 Siena, Italy., Docquier JD; Dipartimento di Biotecnologie Mediche, Università di Siena, 53100 Siena, Italy.; Centre d'Ingénierie des Protéines-InBioS, Université de Liège, B-4000 Liège, Belgium., Hernandez JF; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France., Gavara L; IBMM, CNRS, Univ Montpellier, ENSCM, 34000 Montpellier, France.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16392-16419. Date of Electronic Publication: 2022 Nov 30.