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A nitroalkene derivative of salicylate alleviates diet-induced obesity by activating creatine metabolism and non-shivering thermogenesis.

Autor: Cal K; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Uruguay., Leyva A; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur de Montevideo, IIBCE, Uruguay., Rodríguez-Duarte J; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay., Ruiz S; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay., Santos L; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay., Colella L; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Uruguay., Ingold M; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Uruguay., Vilaseca C; Departamento de Fisiología, Facultad de Medicina, Udelar, Uruguay., Galliussi G; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Laboratory of Immunoregulation and Inflammation; Institut Pasteur Montevideo, Uruguay., Ziegler L; Departamento de Ecología y Gestión Ambiental, Centro Universitario Regional del Este, Udelar, Maldonado, Uruguay., Peclat TR; Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Rochester, MN, USA., Bresque M; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay., Handy RM; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., King R; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown WV, USA., Dos Reis LM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, SP, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, SP, Brazil., Espasandin C; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Unidad Bioquìmica, Facultad de Veterinaria, Udelar, Uruguay., Breining P; Department of Biomedicine, Aarhus University, Denmark., Dapueto R; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Área I+D Biomédico, CUDIM, Uruguay., Lopez A; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Uruguay., Thompson KL; Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Rochester, MN, USA., Agorrody G; Departamento de Fisiopatología, Hospital de Clínicas, Facultad de Medicina, Udelar, Uruguay., DeVallance E; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV, USA., Meadows E; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA., Lewis SE; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, USA., Barbosa GCS; Laboratory of Bioenergetics and Mitochondrial Physiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil., de Souza LOL; Laboratory of Bioenergetics and Mitochondrial Physiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil., Chichierchio MS; Laboratory of Bioenergetics and Mitochondrial Physiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil., Valez V; Cátedra de Bioquímica y Biofísica, Facultad de Odontología, Udelar, Uruguay.; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Uruguay., Aicardo A; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Uruguay.; Departamento de Nutrición Clínica, Escuela de Nutrición, Udelar, Uruguay., Contreras P; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Departamento de Fisiología, Facultad de Medicina, Udelar, Uruguay., Vendelbo MH; Department of Biomedicine, Aarhus University, Denmark.; Department of Nuclear Medicine and PET, Aarhus University Hospital, Denmark., Jakobsen S; Department of Nuclear Medicine and PET, Aarhus University Hospital, Denmark., Kamaid A; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur de Montevideo, IIBCE, Uruguay.; Unidad de Bioimagenología Avanzada. Institut Pasteur de Montevideo, Uruguay., Porcal W; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Uruguay., Calliari A; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.; Unidad Biofísica, Departamento de Biociencias, Facultad de Veterinaria, Udelar, Uruguay., Verdes JM; Unidad Patología, Departamento de Patobiología; Facultad de Veterinaria, Udelar, Uruguay., Du J; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, USA., Wang Y; Department of Ophthalmology and Visual Sciences, Department of Biochemistry, West Virginia University, Morgantown, USA., Hollander JM; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Division of Exercise Physiology, West Virginia University, Morgantown, USA., White TA; Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA., Radi R; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Uruguay., Moyna G; Laboratorio de Fisicoquímica Orgánica, Departamento de Química del Litoral, CENUR Litoral Norte, Udelar, Uruguay., Quijano C; Centro de Investigaciones Biomédicas (CEINBIO), Udelar, Uruguay.; Departamento de Bioquímica, Facultad de Medicina, Udelar, Uruguay., O'Doherty R; Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh, Pennsylvania.; Department of Microbiology and Molecular Genetics; University of Pittsburgh, Pennsylvania., Moraes-Vieira P; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology, and Immunology, Institute of Biology, University of Campinas, SP, Brazil; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, SP, Brazil., Holloway GP; Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada., Leonardi R; Department of Biochemistry and Molecular Medicine, West Virginia University, Morgantown WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), Campinas, SP, Brazil; Instituto Nacional de Obesidade e Diabetes, Campinas, SP, Brazil., Camacho-Pereira J; Laboratory of Bioenergetics and Mitochondrial Physiology, Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro, Brazil., Kelley EE; Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV, USA.; Mitochondria, Metabolism and Bioenergetics Working Group; School of Medicine, West Virginia University, Morgantown, WV, USA.; Center for Inhalation Toxicology (iTOX), School of Medicine, West Virginia University, Morgantown, USA., Duran R; Unidad de Bioquímica y Proteómica Analíticas, Institut Pasteur de Montevideo, IIBCE, Uruguay., Lopez GV; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay.; Departamento de Química Orgánica, Facultad de Química, Udelar, Uruguay., Batthyány C; Laboratory of Vascular Biology and Drug Development, Institut Pasteur Montevideo, Uruguay., Chini EN; Mayo Clinic Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.; Department of Physiology and Biomedical Engineering; Mayo Clinic, Rochester, MN, USA.; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Jacksonville, Florida, USA., Escande C; Laboratory of Metabolic Diseases and Aging, Institut Pasteur Montevideo, Uruguay.

Publikováno v: Research square [Res Sq] 2023 Jul 12. Date of Electronic Publication: 2023 Jul 12.

Jejunum-derived NF-κB reporter organoids as 3D models for the study of TNF-alpha-induced inflammation.

Autor: Daghero H; Cell Biology Unit, Institut Pasteur de Montevideo, Mataojo 2020, 11400, Montevideo, Uruguay., Doffe F; INSERM, UMR 1186, Integrative Tumor Immunology and Immunotherapy, Gustave Roussy, Faculty of Medecine, University Paris-Saclay, 94805, Villejuif, France., Varela B; Pathology Unit, Department of Pathobiology, Faculty of Veterinary, Universidad de la Republica, Route 8, Km. 18 and Route 102, CP 13000, Montevideo, Uruguay., Yozzi V; Pathology Unit, Department of Pathobiology, Faculty of Veterinary, Universidad de la Republica, Route 8, Km. 18 and Route 102, CP 13000, Montevideo, Uruguay., Verdes JM; Pathology Unit, Department of Pathobiology, Faculty of Veterinary, Universidad de la Republica, Route 8, Km. 18 and Route 102, CP 13000, Montevideo, Uruguay., Crispo M; Laboratory Animal Biotechnology Unit, Institut Pasteur de Montevideo, Mataojo 2020, 11400, Montevideo, Uruguay., Bollati-Fogolín M; Cell Biology Unit, Institut Pasteur de Montevideo, Mataojo 2020, 11400, Montevideo, Uruguay. mbollati@pasteur.edu.uy., Pagotto R; Cell Biology Unit, Institut Pasteur de Montevideo, Mataojo 2020, 11400, Montevideo, Uruguay. pagotto@pasteur.edu.uy.

Publikováno v: Scientific reports [Sci Rep] 2022 Aug 24; Vol. 12 (1), pp. 14425. Date of Electronic Publication: 2022 Aug 24.

Ivermectin reduces in vivo coronavirus infection in a mouse experimental model.

Autor: Arévalo AP; Transgenic and Experimental Animal Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay., Pagotto R; Cell Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay., Pórfido JL; Transgenic and Experimental Animal Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay.; Worm Biology Laboratory, Institut Pasteur de Montevideo/Department of Biosciences, Faculty of Chemistry, University of the Republic, Montevideo, Uruguay., Daghero H; Cell Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay., Segovia M; Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.; Immunobiology Department, Faculty of Medicine, University of the Republic, Montevideo, Uruguay., Yamasaki K; Pathobiology Department, Faculty of Veterinary, Pathology Unit, University of the Republic, Montevideo, Uruguay., Varela B; Pathobiology Department, Faculty of Veterinary, Pathology Unit, University of the Republic, Montevideo, Uruguay., Hill M; Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.; Immunobiology Department, Faculty of Medicine, University of the Republic, Montevideo, Uruguay., Verdes JM; Pathobiology Department, Faculty of Veterinary, Pathology Unit, University of the Republic, Montevideo, Uruguay., Duhalde Vega M; Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.; Institute of Biological Chemistry and Chemical Physics (UBA-CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina., Bollati-Fogolín M; Cell Biology Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay., Crispo M; Transgenic and Experimental Animal Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay. crispo@pasteur.edu.uy.

Publikováno v: Scientific reports [Sci Rep] 2021 Mar 30; Vol. 11 (1), pp. 7132. Date of Electronic Publication: 2021 Mar 30.