Human Umbilical Cord-Mesenchymal Stem Cells Promote Extracellular Matrix Remodeling in Microglia.

Autor: Lombardo MT; Institute of Neuroscience, National Research Council of Italy, Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, Piazza dell' Ateneo Nuovo 1, 20126 Milan, Italy., Gabrielli M; Institute of Neuroscience, National Research Council of Italy, Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy., Julien-Marsollier F; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., Faivre V; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., Le Charpentier T; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., Bokobza C; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., D'Aliberti D; Department of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy., Pelizzi N; CARE Franchise, Chiesi Farmaceutici S.p.A., 43122 Parma, Italy., Halimi C; Institute of Neuroscience, National Research Council of Italy, Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy., Spinelli S; Department of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy., Van Steenwinckel J; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., Verderio EAM; School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK.; Department of Biological Sciences (BIGEA), University of Bologna, Via Francesco Selmi 3, 40126 Bologna, Italy., Gressens P; Inserm, NeuroDiderot, Université Paris Cité, 75019 Paris, France., Piazza R; Department of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy., Verderio C; Institute of Neuroscience, National Research Council of Italy, Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy.

Publikováno v: Cells [Cells] 2024 Oct 09; Vol. 13 (19). Date of Electronic Publication: 2024 Oct 09.

Paired plasma lipidomics and proteomics analysis in the conversion from mild cognitive impairment to Alzheimer's disease.

Autor: Gómez-Pascual A; Department of Information and Communications Engineering Faculty of Informatics, University of Murcia, Murcia, Spain; Steno Diabetes Center Copenhagen, Herlev, Denmark., Naccache T; Department of Data Science, City University of London, United Kingdom., Xu J; Institute of Pharmaceutical Science, King's College London, London, United Kingdom., Hooshmand K; Steno Diabetes Center Copenhagen, Herlev, Denmark., Wretlind A; Steno Diabetes Center Copenhagen, Herlev, Denmark., Gabrielli M; CNR Institute of Neuroscience, 20854, Vedano al Lambro, Italy., Lombardo MT; CNR Institute of Neuroscience, 20854, Vedano al Lambro, Italy; School of Medicine and Surgery, University of Milano-Bicocca, 20126, Italy., Shi L; Novo Nordisk Research Centre Oxford (NNRCO), Oxford, United Kingdom., Buckley NJ; Department of Psychiatry, University of Oxford, United Kingdom; Kavli Institute for Nanoscience Discovery, Denmark., Tijms BM; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Vos SJB; Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Ten Kate M; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands., Engelborghs S; Reference Center for Biological Markers of Dementia (BIODEM), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology and Bru-BRAIN, UZ Brussel and Center for Neurosciences (C4N), Vrije Universiteit Brussel, Brussels, Belgium., Sleegers K; Complex Genetics Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium; Institute Born-Bunge, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium., Frisoni GB; University of Geneva, Geneva, Switzerland; IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy., Wallin A; Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden., Lleó A; Neurology Department, Hospital Sant Pau, Barcelona, Spain, Centro de Investigación en Red en enfermedades neurodegenerativas (CIBERNED)., Popp J; Old age psychiatry, University Hospital of Lausanne, University of Lausanne, Switzerland; Department of Geriatric Psychiatry, University Hospital of Psychiatry Zürich, University of Zürich, Switzerland., Martinez-Lage P; CITA-Alzheimer Foundation, San Sebastian, Spain., Streffer J; AC Immune SA, Lausanne, Switzerland, formerly Janssen R&D, LLC. Beerse, Belgium at the time of study conduct., Barkhof F; Department of Radiology and Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, the Netherlands; Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, United Kingdom., Zetterberg H; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden; UK Dementia Research Institute at UCL, London, United Kingdom; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom., Visser PJ; Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands; Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Maastricht University, Maastricht, the Netherlands., Lovestone S; Department of Psychiatry, University of Oxford, United Kingdom; Janssen Medical (UK), High Wycombe, United Kingdom., Bertram L; Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany; Department of Psychology, University of Oslo, Oslo, Norway., Nevado-Holgado AJ; Department of Psychiatry, University of Oxford, United Kingdom., Gualerzi A; IRCCS Fondazione Don Carlo Gnocchi ONLUS in Milan, Italy., Picciolini S; IRCCS Fondazione Don Carlo Gnocchi ONLUS in Milan, Italy., Proitsi P; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom., Verderio C; CNR Institute of Neuroscience, 20854, Vedano al Lambro, Italy., Botía JA; Department of Information and Communications Engineering Faculty of Informatics, University of Murcia, Murcia, Spain., Legido-Quigley C; Steno Diabetes Center Copenhagen, Herlev, Denmark; Institute of Pharmaceutical Science, King's College London, London, United Kingdom. Electronic address: cristina.legido_quigley@kcl.ac.uk.

Publikováno v: Computers in biology and medicine [Comput Biol Med] 2024 Jun; Vol. 176, pp. 108588. Date of Electronic Publication: 2024 May 13.

Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1 ^G93A pigs.

Autor: Golia MT; National Research Council of Italy, Institute of Neuroscience (IN-CNR), Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy., Frigerio R; National Research Council of Italy, Institute of Chemical Science and Technologies (SCITEC-CNR), Via Mario Bianco 9, 20131 Milan, Italy., Pucci S; National Research Council of Italy, Institute of Neuroscience (IN-CNR), Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy., Sironi F; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156 Milano, Italy., Margotta C; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156 Milano, Italy., Pasetto L; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156 Milano, Italy., Testori C; Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta (IZSPLV), Via Bologna 148, 10154 Torino, Italy., Berrone E; Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta (IZSPLV), Via Bologna 148, 10154 Torino, Italy., Ingravalle F; Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta (IZSPLV), Via Bologna 148, 10154 Torino, Italy., Chiari M; National Research Council of Italy, Institute of Chemical Science and Technologies (SCITEC-CNR), Via Mario Bianco 9, 20131 Milan, Italy., Gori A; National Research Council of Italy, Institute of Chemical Science and Technologies (SCITEC-CNR), Via Mario Bianco 9, 20131 Milan, Italy., Duchi R; Avantea, Laboratory of Reproductive Technologies, Via Porcellasco 7/F, 26100 Cremona, Italy., Perota A; Avantea, Laboratory of Reproductive Technologies, Via Porcellasco 7/F, 26100 Cremona, Italy., Bergamaschi L; Avantea, Laboratory of Reproductive Technologies, Via Porcellasco 7/F, 26100 Cremona, Italy., D'Angelo A; Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Torino, Italy., Cagnotti G; Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Torino, Italy., Galli C; Avantea, Laboratory of Reproductive Technologies, Via Porcellasco 7/F, 26100 Cremona, Italy., Corona C; Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d'Aosta (IZSPLV), Via Bologna 148, 10154 Torino, Italy., Bonetto V; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156 Milano, Italy., Bendotti C; Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Mario Negri, 2, 20156 Milano, Italy., Cretich M; National Research Council of Italy, Institute of Chemical Science and Technologies (SCITEC-CNR), Via Mario Bianco 9, 20131 Milan, Italy., Colombo SF; National Research Council of Italy, Institute of Neuroscience (IN-CNR), Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy., Verderio C; National Research Council of Italy, Institute of Neuroscience (IN-CNR), Via Raoul Follereau 3, 20854 Vedano al Lambro, Italy. Electronic address: c.verderio@in.cnr.it.

Publikováno v: Experimental neurology [Exp Neurol] 2024 Apr; Vol. 374, pp. 114716. Date of Electronic Publication: 2024 Feb 06.

Extracellular vesicles released by microglia and macrophages carry endocannabinoids which foster oligodendrocyte differentiation.

Autor: Lombardi M; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy.; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Scaroni F; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy., Gabrielli M; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy.; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Raffaele S; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Bonfanti E; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Filipello F; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Humanitas Research Hospital, Rozzano, Italy., Giussani P; Department of Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Segrate, Italy., Picciolini S; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Fondazione Don Carlo Gnocchi Onlus, Milan, Italy., de Rosbo NK; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Ospedale Policlinico San Martino, Genoa, Italy.; TomaLab, Institute of Nanotechnology, CNR, Rome, Italy., Uccelli A; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Ospedale Policlinico San Martino, Genoa, Italy.; Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy., Golia MT; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy.; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., D'Arrigo G; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy.; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Rubino T; Department of Biotechnology and Life Sciences (DBSV) and Neuroscience Center, University of Insubria, Busto Arsizio, Italy., Hooshmand K; System Medicine, Steno Diabetes Center Copenhagen, Copenhagen, Denmark., Legido-Quigley C; System Medicine, Steno Diabetes Center Copenhagen, Copenhagen, Denmark.; Institute of Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Fenoglio C; Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy.; Fondazione Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy., Gualerzi A; Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Fondazione Don Carlo Gnocchi Onlus, Milan, Italy., Fumagalli M; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy., Verderio C; Department of Biomedical Sciences, National Research Council (CNR) Institute of Neuroscience, Vedano al Lambro, Italy.; NeuroMI Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.

Publikováno v: Frontiers in immunology [Front Immunol] 2024 Feb 23; Vol. 15, pp. 1331210. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).

Exosomal profiling should be used to monitor disease activity in MS patients: Commentary.

Autor: Gabrielli M; CNR Institute of Neuroscience, Milan, Italy; NeuroMI - Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy., Verderio C; CNR Institute of Neuroscience, Milan, Italy; NeuroMI - Milan Center for Neuroscience, University of Milano-Bicocca, Milan, Italy.

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2023 Sep; Vol. 29 (10), pp. 1208. Date of Electronic Publication: 2023 Sep 07.