Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.

Autor: de Rooij JD; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Branstetter C; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Ma J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Li Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Walsh MP; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Cheng J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Obulkasim A; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Dang J; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Verboon LJ; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Mulder HL; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Zimmermann M; Department of Pediatric Hematology/Oncology, Medical School Hannover, Hannover, Germany., Koss C; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Gupta P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Edmonson M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Lim JY; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Reinhardt K; Department of Pediatric Oncology, University of Duisburg-Essen, Essen, Germany., Pigazzi M; Department of Women's and Children's Health, University of Padova, Padova, Italy., Song G; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Yeoh AE; Department of Pediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Cancer Science Institute, National University of Singapore, Singapore., Shih LY; Chang Gung Memorial Hospital-Linkou, Chang Gung University, Taoyuan City, Taiwan., Liang DC; Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan., Halene S; Section of Hematology, Department of Internal Medicine and Yale Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA., Krause DS; Department of Laboratory Medicine, Yale University, New Haven, Connecticut, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Locatelli F; Department of Pediatric Hematology Oncology, University of Pavia, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy., Reinhardt D; Department of Pediatric Oncology, University of Duisburg-Essen, Essen, Germany., van den Heuvel-Eibrink MM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.; Department of Pediatric Oncology, Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands., Zwaan CM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Fornerod M; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Gruber TA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

Publikováno v: Nature genetics [Nat Genet] 2017 Mar; Vol. 49 (3), pp. 451-456. Date of Electronic Publication: 2017 Jan 23.

MicroRNA-106b~25 cluster is upregulated in relapsed MLL-rearranged pediatric acute myeloid leukemia.

Autor: Verboon LJ; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., Obulkasim A; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., de Rooij JD; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., Katsman-Kuipers JE; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., Sonneveld E; Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands., Baruchel A; Department of Hematology, Hopital Saint- Louis, Paris, France., Trka J; Department of Pediatric Hematology/Oncology, 2nd Medical School, Charles University, Prague, Czech Republic., Reinhardt D; Clinic for Pediatrics III, University Hospital Essen, Essen, Germany., Pieters R; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands., Cloos J; Paediatric Oncology/Haematology, VU University Medical Centre, Amsterdam, The Netherlands., Kaspers GJ; Paediatric Oncology/Haematology, VU University Medical Centre, Amsterdam, The Netherlands., Klusmann JH; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany., Zwaan CM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., Fornerod M; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands., van den Heuvel-Eibrink MM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam, The Netherlands.; Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands.

Publikováno v: Oncotarget [Oncotarget] 2016 Jul 26; Vol. 7 (30), pp. 48412-48422.

Mapping epigenetic regulator gene mutations in cytogenetically normal pediatric acute myeloid leukemia.

Autor: Valerio DG; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Katsman-Kuipers JE; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Jansen JH; Department of Hematology, Radboud UMC, Nijmegen, the Netherlands., Verboon LJ; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., de Haas V; Dutch Childhood Oncology Group (DCOG), The Hague, The Netherlands., Stary J; Pediatric Hematology/Oncology, 2 Medical School, Charles University, Prague, Czech Republic., Baruchel A; AP-HP, Hôpital Robert Debré and Université Paris Diderot, Paris, France., Zimmermann M; AML-BFM Study Group, Department of Pediatric Oncology/Hematology, Medical High School, Hannover, Germany., Pieters R; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Reinhardt D; AML-BFM Study Group, Department of Pediatric Oncology/Hematology, Medical High School, Hannover, Germany., van den Heuvel-Eibrink MM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands., Zwaan CM; Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands c.m.zwaan@erasmusmc.nl.

Publikováno v: Haematologica [Haematologica] 2014 Aug; Vol. 99 (8), pp. e130-2. Date of Electronic Publication: 2014 May 09.