Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Verbena Kosovrasti"'
Autor:
Christian Wolfrum, Nikolay V. Dokholyan, Gang Wang, Valerie A. Clausen, Julia Hettinger, Svetlana Shulga Morskaya, Qianfan Wang, Joshua Brodsky, Verbena Kosovrasti, Xuemei Zhang, Dinah W.Y. Sah, Mike Meys, Kallanthottathil G. Rajeev, Yupang Fang, Muthiah Manoharan, Jennifer Sharman, Martin Maier, Feng Ding, Mariano Severgnini, Victor Kotelianski, Lubomir Tchangov, Renta Hutabarat, Chang Geng Peng, Robert Li, Tim Racie, Lubomir Nechev, James Butler, Tomoko Nakayama, Scott A Barros, Alfica Sehgal, Markus Stoffel
Publikováno v:
Molecular Therapy, 20 (8)
Molecular Therapy
MOLECULAR THERAPY
Molecular Therapy
MOLECULAR THERAPY
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of the corresponding pathogenic protein. The major challenge
Autor:
Douglas Ulen Gwost, Verbena Kosovrasti, Michael Meys, Dinah W.Y. Sah, Gregory R. Stewart, Peter A. Hardy, Lubomir Nechev, Pei Ge, Muthiah Manoharan, Klaus Charisse, Yi Ai, Lubomir Tchangov, David K. Stiles, Don M. Gash, Andrei Guzaev, Richard Grondin, Peter T. Nelson, Zhiming Zhang, Brian D. Nelson, William F. Kaemmerer, Martin Maier, Mark T. Butt
Publikováno v:
Experimental Neurology. 233:463-471
Huntington's disease is an autosomal dominant neurodegenerative disease caused by a toxic gain of function mutation in the huntingtin gene (Htt). Silencing of Htt with RNA interference using direct CNS delivery in rodent models of Huntington's diseas
Autor:
Ammen P. Sandhu, Scott A Barros, William Cantley, Ying K. Tam, Masuna Srinivasulu, Verbena Kosovrasti, Akin Akinc, Kieu Lam, Kallanthottathil G. Rajeev, Marco A. Ciufolini, Dinah W.Y. Sah, Soma De, Lloyd Jeffs, Ismail M. Hafez, Qingmin Chen, Thomas D. Madden, Antonin de Fougerolles, Ed Yaworski, June Qin, Mark A Tracy, Pieter R. Cullis, Barbara L. Mui, Jianxin Chen, Michael J. Hope, Martin Maier, Sandra K. Klimuk, Rene Alvarez, Connie K Cho, Michael J Weinstein, Muthiah Manoharan, Kim F. Wong, Mikameh Kazem, Derrick Stebbing, Merete L. Eisenhardt, Ian MacLachlan, Lubomir Nechev, Erin J Crosley, Muthusamy Jayaraman, J. Robert Dorkin, Sean C. Semple, Todd Borland
Publikováno v:
Nature Biotechnology. 28:172-176
We adopted a rational approach to design cationic lipids for use in formulations to deliver small interfering RNA (siRNA). Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-dimethylaminopropane (DLinDMA), a key lipid component of stable