SARS-CoV-2 variants evolve convergent strategies to remodel the host response

Autor: Bouhaddou, Mehdi, Reuschl, Ann-Kathrin, Polacco, Benjamin J., Thorne, Lucy G., Ummadi, Manisha R., Ye, Chengjin, Rosales, Romel, Pelin, Adrian, Batra, Jyoti, Jang, Gwendolyn M., Xu, Jiewei, Moen, Jack M., Richards, Alicia L., Zhou, Yuan, Harjai, Bhavya, Stevenson, Erica, Rojc, Ajda, Ragazzini, Roberta, Whelan, Matthew V.X., Furnon, Wilhelm, De Lorenzo, Giuditta, Cowton, Vanessa, Syed, Abdullah M., Ciling, Alison, Deutsch, Noa, Pirak, Daniel, Dowgier, Giulia, Mesner, Dejan, Turner, Jane L., McGovern, Briana L., Rodriguez, M. Luis, Leiva-Rebollo, Rocio, Dunham, Alistair S., Zhong, Xiaofang, Eckhardt, Manon, Fossati, Andrea, Liotta, Nicholas F., Kehrer, Thomas, Cupic, Anastasija, Rutkowska, Magdalena, Mena, Ignacio, Aslam, Sadaf, Hoffert, Alyssa, Foussard, Helene, Olwal, Charles Ochieng’, Huang, Weiqing, Zwaka, Thomas, Pham, John, Lyons, Molly, Donohue, Laura, Griffin, Aliesha, Nugent, Rebecca, Holden, Kevin, Deans, Robert, Aviles, Pablo, Lopez-Martin, Jose A., Jimeno, Jose M., Obernier, Kirsten, Fabius, Jacqueline M., Soucheray, Margaret, Hüttenhain, Ruth, Jungreis, Irwin, Kellis, Manolis, Echeverria, Ignacia, Verba, Kliment, Bonfanti, Paola, Beltrao, Pedro, Sharan, Roded, Doudna, Jennifer A., Martinez-Sobrido, Luis, Patel, Arvind H., Palmarini, Massimo, Miorin, Lisa, White, Kris, Swaney, Danielle L., Garcia-Sastre, Adolfo, Jolly, Clare, Zuliani-Alvarez, Lorena, Towers, Greg J., Krogan, Nevan J.

Publikováno v: In Cell 12 October 2023 186(21):4597-4614

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Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

Autor: Remesh, Soumya G, Merz, Gregory E, Brilot, Axel F, Chio, Un Seng, Rizo, Alexandrea N, Pospiech, Thomas H, Lui, Irene, Laurie, Mathew T, Glasgow, Jeff, Le, Chau Q, Zhang, Yun, Diwanji, Devan, Hernandez, Evelyn, Lopez, Jocelyne, Mehmood, Hevatib, Pawar, Komal Ishwar, Pourmal, Sergei, Smith, Amber M, Zhou, Fengbo, QCRG Structural Biology Consortium, DeRisi, Joseph, Kortemme, Tanja, Rosenberg, Oren S, Glasgow, Anum, Leung, Kevin K, Wells, James A, Verba, Kliment A

Publikováno v: Structure (London, England : 1993), vol 31, iss 3

The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor-binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered theSARS-CoV-2 host entry receptor, ACE2, to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::caf7bc62ae64e02b98b60286af094cf9
https://escholarship.org/uc/item/8nf664kq

Efficient expression, purification, and visualization by cryo-EM of unliganded near full-length HER3

Autor: Diwanji, Devan, Trenker, Raphael, Jura, Natalia, Verba, Kliment A

Publikováno v: Methods in Enzymology ISBN: 9780323915410
Methods Enzymol

Biochemical analyses of membrane receptor kinases have been limited by challenges in obtaining sufficient homogeneous receptor samples for downstream structural and biophysical characterization. Here, we report a suite of methods for the efficient ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0aaecbbd5de37a8b98bc1367aaa5877
https://doi.org/10.1016/bs.mie.2022.03.048