The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease

Autor: Lin, C., Happe, H., Veraar, K., Scharpfenecker, M., Peters, D.J.M., Dipak Consortium

Publikováno v: Experimental Biology and Medicine
Experimental Biology and Medicine, 243(13), 1092-1098

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive renal cyst formation and expansion. Several clinical trials show that somatostatin analogs halt cyst growth and progression of ADPKD by inhibiting adenosine 3′,5�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efc509d3a38bb9858a3b9cb37818e79
https://hdl.handle.net/1887/86535

Polycystin-1 dysfunction impairs electrolyte and water handling in a renal precystic mouse model for ADPKD.

Autor: Verschuren EHJ; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands., Mohammed SG; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands., Leonhard WN; Department of Human Genetics, Leiden University Medical Centre , Leiden , The Netherlands., Overmars-Bos C; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands., Veraar K; Department of Human Genetics, Leiden University Medical Centre , Leiden , The Netherlands., Hoenderop JGJ; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands., Bindels RJM; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands., Peters DJM; Department of Human Genetics, Leiden University Medical Centre , Leiden , The Netherlands., Arjona FJ; Department of Physiology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center , Nijmegen , The Netherlands.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2018 Sep 01; Vol. 315 (3), pp. F537-F546. Date of Electronic Publication: 2018 May 16.

Cross-Species Insights into Autosomal Dominant Polycystic Kidney Disease: Provide an Alternative View on Research Advancement.

Autor: Luo, Jianing¹ (AUTHOR) luojianing@zju.edu.cn, Zhang, Yuan¹ (AUTHOR) zhangyuan2020@zju.edu.cn, Jayaprakash, Sakthidasan² (AUTHOR) jsakthi88@gmail.com, Zhuang, Lenan¹ (AUTHOR) zhuangln@zju.edu.cn, He, Jin¹ (AUTHOR) hejin@zju.edu.cn

Publikováno v: International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5646. 22p.

Inhibition of Activin Signaling Slows Progression of Polycystic Kidney Disease.

Autor: Leonhard WN; Departments of Human Genetics., Kunnen SJ; Departments of Human Genetics., Plugge AJ; Departments of Human Genetics., Pasternack A; Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland; and., Jianu SB; Departments of Human Genetics., Veraar K; Pathology, and., El Bouazzaoui F; Departments of Human Genetics., Hoogaars WM; Department of Human Movement Sciences, Faculty of Behavior and Movement Sciences, Vrije Universiteit Amsterdam, MOVE Research Institute, Amsterdam, The Netherlands., Ten Dijke P; Molecular Cell Biology and Cancer Genomics Centre Netherlands at the Leiden University Medical Center, Leiden, The Netherlands., Breuning MH; Departments of Human Genetics., De Heer E; Pathology, and., Ritvos O; Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland; and., Peters DJ; Departments of Human Genetics, d.j.m.peters@lumc.nl.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2016 Dec; Vol. 27 (12), pp. 3589-3599. Date of Electronic Publication: 2016 Mar 28.

Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease.

Autor: Leonhard WN; Departments of Human Genetics., Zandbergen M; Pathology, and., Veraar K; Pathology, and., van den Berg S; Departments of Human Genetics., van der Weerd L; Departments of Human Genetics, Radiology, Leiden University Medical Center, Leiden, The Netherlands., Breuning M; Departments of Human Genetics., de Heer E; Pathology, and., Peters DJ; Departments of Human Genetics, d.j.m.peters@lumc.nl.

Publikováno v: Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2015 Jun; Vol. 26 (6), pp. 1322-33. Date of Electronic Publication: 2014 Oct 31.