Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vera Wagschal"'
BackgroundCardiac glycosides are known to fatally inhibit the Na,K-ATPase throughout the animal kingdom. Several animals, however, evolved target-site insensitivity by substitutions in the otherwise highly conserved cardiac glycoside binding pocket l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b59ab8518ff7c66780738ab918eb56
https://doi.org/10.1101/2020.08.28.272054
https://doi.org/10.1101/2020.08.28.272054
Publikováno v:
Entomologia Experimentalis et Applicata. 157:30-39
Cardiac glycosides are a prime example of highly toxic plant secondary compounds, which block an essential transmembrane carrier in animals, the Na,K-ATPase. Nevertheless, over 100 insect species from diverse orders are known to feed on plants contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c3436bfc9ae29318a0aa60559d4202
https://doi.org/10.1111/eea.12340
https://doi.org/10.1111/eea.12340
Publikováno v:
The American naturalist. 190(S1)
Natural selection imposed by natural toxins has led to striking levels of convergent evolution at the molecular level. Cardiac glycosides represent a group of plant toxins that block the Na,K-ATPase, a vital membrane protein in animals. Several herbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702c8cf55b8a031fdcc92390ca57e549
https://pubmed.ncbi.nlm.nih.gov/28731826
https://pubmed.ncbi.nlm.nih.gov/28731826
Autor:
Niels Pietsch, Vera Wagschal, Susanne Dobler, Renja Romey-Glüsing, Kai Schütte, Nadja Dahdouli, Fee Meinzer
Publikováno v:
Proc Biol Sci
Evolution of insensitivity to the toxic effects of cardiac glycosides has become a model in the study of convergent evolution, as five taxonomic orders of insects use the same few similar amino acid substitutions in the otherwise highly conserved Na,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121784b6d8ce3b6ba2984a7f2c51071
https://doi.org/10.1098/rspb.2019.0883
https://doi.org/10.1098/rspb.2019.0883
Autor:
Vera Wagschal, Georg Petschenka, Nils Sander, Susanne Dobler, Michael Boppré, Steffi Fandrich
Publikováno v:
Evolution. 67:2753-2761
Despite the monarch butterfly (Danaus plexippus) being famous for its adaptations to the defensive traits of its milkweed host plants, little is known about the macroevolution of these traits. Unlike most other animal species, monarchs are largely in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2094787f29ca3b469094b2a48702f038
https://doi.org/10.1111/evo.12152
https://doi.org/10.1111/evo.12152
Publikováno v:
Proceedings of the National Academy of Sciences. 109:13040-13045
The extent of convergent molecular evolution is largely unknown, yet is critical to understanding the genetics of adaptation. Target site insensitivity to cardenolides is a prime candidate for studying molecular convergence because herbivores in six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5038f24742725dee946a9b94b12579
https://doi.org/10.1073/pnas.1202111109
https://doi.org/10.1073/pnas.1202111109
Autor:
Georg, Petschenka, Steffi, Fandrich, Nils, Sander, Vera, Wagschal, Michael, Boppré, Susanne, Dobler
Publikováno v:
Evolution; international journal of organic evolution. 67(9)
Despite the monarch butterfly (Danaus plexippus) being famous for its adaptations to the defensive traits of its milkweed host plants, little is known about the macroevolution of these traits. Unlike most other animal species, monarchs are largely in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9de955b405af2591c0b2f8265614e399
https://pubmed.ncbi.nlm.nih.gov/24033181
https://pubmed.ncbi.nlm.nih.gov/24033181
Publikováno v:
Proceedings of the Royal Society B: Biological Sciences. 280:20123089
Because cardenolides specifically inhibit the Na+K+-ATPase, insects feeding on cardenolide-containing plants need to circumvent this toxic effect. Some insects such as the monarch butterfly rely on target site insensitivity, yet other cardenolide-ada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307da6019bbcb5b0cff581848c3ec298
https://doi.org/10.1098/rspb.2012.3089
https://doi.org/10.1098/rspb.2012.3089