In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma

Autor: Solveig Lemmel, Markus Weckmann, Anna Wohlers, Adan Chari Jirmo, Ruth Grychtol, Isabell Ricklefs, Gyde Nissen, Anna Bachmann, Shantanu Singh, Juan Caicedo, Thomas Bahmer, Gesine Hansen, Erika Von Mutius, Klaus F. Rabe, Oliver Fuchs, Anna-Maria Dittrich, Bianca Schaub, Christine Happle, Anne E. Carpenter, Matthias Volkmar Kopp, Tim Becker, the ALLIANCE Study Group as part of the German Centre for Lung Research (DZL), Mustafa Abdo, Miguel Alcazar, Mira Berbig, Heike Biller, Xenia Bovermann, Folke Brinkmann, Mifflin-Rae Calveron, David S. DeLuca, Gesa Diekmann, Christian Dopfer, Markus Ege, Svenja Foth, Svenja Gaedcke, Karoline I. Gaede, Anika Habener, Christian Herzmann, Alexander Hose, Sabina Illi, Anne-Marie Kirsten, Naschla Kohistani-Greif, Inke R. König, Silke Van Koningsbruggen-Rietschel, Matthias V. Kopp, Johanna Kurz, Katja Landgraf-Rauf, Kristina Laubhahn, Lena Liboschik, Claudia Liebl, Berrit Liselotte Husstedt, Bin Liu, Nicole Maison, Aydin Malik, Carola Marzi, Meike Meyer, Catharina Nitsche, Frauke Pedersen, Mareike Price, Harald Renz, Ernst Rietschel, Barbara Roesler, Christina Schauberger, Tom Schildberg, Carsten Schmidt-Weber, Nicolaus Schwerk, Chrysanthi Skevaki, Alena Steinmetz, Laila Sultansei, Marlen Szewczyk, Dominik Thiele, Vera Veith, Gesche Voigt, Benjamin Waschki, Henrik Watz, Stefanie Weber, Nils Welchering, Esther Zeitlmann, Ulrich Zissler

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocytes (NGs) fro

Externí odkaz: https://doaj.org/article/fc7e3e168608484cb6c82625730f72c5

T2-high asthma phenotypes across lifespan

Autor: Nicole, Maison, Jimmy, Omony, Sabina, Illi, Dominik, Thiele, Chrysanthi, Skevaki, Anna-Maria, Dittrich, Thomas, Bahmer, Klaus Friedrich, Rabe, Markus, Weckmann, Christine, Happle, Bianca, Schaub, Meike, Meyer, Svenja, Foth, Ernst, Rietschel, Harald, Renz, Gesine, Hansen, Matthias Volkmar, Kopp, Erika, von Mutius, Ruth, Grychtol, Oliver, Fuchs, Barbara, Roesler, Nils, Welchering, Naschla, Kohistani-Greif, Johanna, Kurz, Katja, Landgraf-Rauf, Kristina, Laubhahn, Claudia, Liebl, Markus, Ege, Alexander, Hose, Esther, Zeitlmann, Mira, Berbig, Carola, Marzi, Christina, Schauberger, Ulrich, Zissler, Carsten, Schmidt-Weber, Isabell, Ricklefs, Gesa, Diekmann, Lena, Liboschik, Gesche, Voigt, Laila, Sultansei, Gyde, Nissen, Inke R, König, Anne-Marie, Kirsten, Frauke, Pedersen, Henrik, Watz, Benjamin, Waschki, Christian, Herzmann, Mustafa, Abdo, Heike, Biller, Karoline I, Gaede, Xenia, Bovermann, Alena, Steinmetz, Berrit Liselotte, Husstedt, Catharina, Nitsche, Vera, Veith, Marlen, Szewczyk, Folke, Brinkmann, Aydin, Malik, Nicolaus, Schwerk, Christian, Dopfer, Mareike, Price, Adan Chari, Jirmo, Anika, Habener, David S, DeLuca, Svenja, Gaedcke, Bin, Liu, Mifflin-Rae, Calveron, Stefanie, Weber, Tom, Schildberg, Silke, van Koningsbruggen-Rietschel, Miguel, Alcazar

Publikováno v: The European respiratory journal. 60(3)

RationaleIn adults, personalised asthma treatment targets patients with type 2 (T2)-high and eosinophilic asthma phenotypes. It is unclear whether such classification is achievable in children.ObjectivesTo define T2-high asthma with easily accessible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5935e68e18e5454ad68c21d641201c
https://pubmed.ncbi.nlm.nih.gov/36175027

Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study

Autor: Erika von Mutius, Frauke Pedersen, Gesine Hansen, Anne-Marie Kirsten, Matthias V. Kopp, Benjamin Waschki, Mustafa Abdo, Frederik Trinkmann, Henrik Watz, Klaus F. Rabe, Thomas Bahmer, Heike Biller, Vera Veith

Publikováno v: Respiratory Research
Respiratory Research, Vol 21, Iss 1, Pp 1-7 (2020)
Abdo, Mustafa; Watz, Henrik; Veith, Vera; Kirsten, Anne-Marie; Biller, Heike; Pedersen, Frauke; von Mutius, Erika; Kopp, Matthias V.; Hansen, Gesine; Waschki, Benjamin; Rabe, Klaus F.; Trinkmann, Frederik; Bahmer, Thomas (2020). Small airway dysfunction as predictor and marker for clinical response to biological therapy in severe eosinophilic asthma: a longitudinal observational study. Respiratory Research, 21(1), p. 278. 10.1186/s12931-020-01543-5

Background Anti-T2 biological therapies have proven to effectively reduce acute exacerbations and daily doses of oral steroids in severe eosinophilic asthma. Despite the remarkable clinical efficacy, there are usually only moderate improvements in ai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6c88b7cbe12fab7f46648c599843f15
https://doi.org/10.1186/s12931-020-01543-5