Výsledky vyhledávání - "Vera Schregel"

Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly

Autor: Mengya Liu, Morgan R. Herod, Vera Schregel, Christopher McCormick, Chris Hinds, Rozanne M. Sandri-Goldin, John McLauchlan

Publikováno v: Journal of Virology. 88:2748-2762

Within the polyprotein encoded by hepatitis C virus (HCV), the minimum components required for viral RNA replication lie in the NS3-5B region, while virion assembly requires expression of all virus components. Here, we have employed complementation s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23609db4d2a4b9731f0ad4ffdaafa3bb
https://doi.org/10.1128/jvi.03588-13

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Mapping of a self-interaction domain of the cytomegalovirus protein kinase pUL97

Autor: Sabrina Auerochs, Vera Schregel, Katja Maurer, Ramona Jochmann, Thomas Stamminger, Manfred Marschall

Publikováno v: Journal of General Virology. 88:395-404

The human cytomegalovirus-encoded protein kinase pUL97 is a determinant of efficient virus replication and fulfils several regulatory functions. In particular, pUL97 interacts with and phosphorylates viral and cellular proteins. Substrate phosphoryla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f6540b73a8176aeda50fb72a9d4943
https://doi.org/10.1099/vir.0.82393-0

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Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation

Autor: Sabrina Auerochs, Thomas Wittenberg, Jens Milbradt, Vera Schregel, Katharina Nöbauer, Manfred Marschall, Ebrahim Razzazi-Fazeli, Christophe Jardin, Christian Held, Rike Webel, Heinrich Sticht

The pUL97 protein kinase encoded by human cytomegalovirus is a multifunctional determinant of the efficiency of viral replication and phosphorylates viral as well as cellular substrate proteins. Here, we report that pUL97 is expressed in two isoforms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a14696215eb27448017c4beac24b3609
https://publica.fraunhofer.de/handle/publica/225304

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Analysis of the structure-activity relationship of four herpesviral UL97 subfamily protein kinases reveals partial but not full functional conservation

Autor: Andrea Marzi, Manfred Marschall, Vera Schregel, Sabrina Auerochs, Daniel Romaker, Katja Maurer, Heinrich Sticht

Publikováno v: Journal of medicinal chemistry. 49(24)

Herpesviral protein kinases of the UL97 subfamily are expressed by all known herpesviruses but the degree of functional conservation is unclear. A selection of representative members was investigated by a comparative structural and functional analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6764e9c5e5c814a6445b801f3338ab55
https://pubmed.ncbi.nlm.nih.gov/17125257

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Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene

Autor: Michael Goltz, Vera Schregel, Manfred Marschall, Güzin Dural, Jochen Hentschke, Bernhard Ehlers

Publikováno v: The Journal of general virology. 87(Pt 10)

Endotheliotropic elephant herpesvirus (elephantid herpesvirus 1; ElHV-1) is apathogenic for African elephants (Loxodonta africana), but causes fatal haemorrhagic disease in Asian elephants (Elephas maximus). This is thought to occur through transmiss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f04b423ecb7deb59a7e151fb4b37ed3
https://pubmed.ncbi.nlm.nih.gov/16963736

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