Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Vera Roginskaya"'
Autor:
Brittani L. Schnable, Matthew A. Schaich, Vera Roginskaya, Liam P. Leary, Tyler M. Weaver, Bret D. Freudenthal, Alexander C. Drohat, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Base excision repair is the main pathway involved in active DNA demethylation. 5-formylcytosine and 5-carboxylcytosine, two oxidized moieties of methylated cytosine, are recognized and removed by thymine DNA glycosylase (TDG) to generate an
Externí odkaz:
https://doaj.org/article/c5ab3255991842278bb091539a39a8ac
Autor:
Namrata Kumar, Arjan F. Theil, Vera Roginskaya, Yasmin Ali, Michael Calderon, Simon C. Watkins, Ryan P. Barnes, Patricia L. Opresko, Alex Pines, Hannes Lans, Wim Vermeulen, Bennett Van Houten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Nucleotide excision repair proteins are involved in the repair of UV-induced DNA damage. Here, the authors show that NER proteins, DDB2, XPC, and XPA play a vital role in the 8-oxoguanine repair by coordinating with base excision repair protein OGG1.
Externí odkaz:
https://doaj.org/article/677d2112db5041e7bd30b5fcd641a24a
Autor:
Dong Wang, Robert Hartman, Chao Han, Chao-ming Zhou, Brandon Couch, Matias Malkamaki, Vera Roginskaya, Bennett Van Houten, Steven J. Mullett, Stacy G. Wendell, Michael J. Jurczak, James Kang, Joon Lee, Gwendolyn Sowa, Nam Vo
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-15 (2021)
Abstract Background Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulpous (NP) surrounded by the more oxygenated annulus fibrosus (AF). Lactic acid, an abundant
Externí odkaz:
https://doaj.org/article/c277863dd836412d934d854ba2944040
Autor:
Ryan P. Barnes, Mariarosaria de Rosa, Sanjana A. Thosar, Ariana C. Detwiler, Vera Roginskaya, Bennett Van Houten, Marcel P. Bruchez, Jacob Stewart-Ornstein, Patricia L. Opresko
Publikováno v:
Nature Structural & Molecular Biology. 29:639-652
Oxidative stress is a primary cause of cellular senescence and contributes to the etiology of numerous human diseases. Oxidative damage to telomeric DNA has been proposed to cause premature senescence by accelerating telomere shortening. Here, we tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c30a54e92e0b0240046eb4a31042ad
https://doi.org/10.1038/s41594-022-00790-y
https://doi.org/10.1038/s41594-022-00790-y
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Suppl. Table 1: IC50 values for the DNA Ligase inhibitor L67 for three cancer cells lines, a telomerase-immortalized fibroblast and the Rho minus derivatives of each of the cell lines; Suppl. Table 2: DNA sequences of primers used for amplification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fe2b33ba51181bcda1b44240e6a897
https://doi.org/10.1158/0008-5472.22412627.v1
https://doi.org/10.1158/0008-5472.22412627.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Effect of L67 on the cell cycle distribution of synchronized HCA-Ltrt cells. Panel B. Effect of L67 on mitochondrial superoxide level in HCA-Ltrt cells and HCA-Ltrt Rho minus cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3581fe508af73c5a8f2c916c554d116
https://doi.org/10.1158/0008-5472.22412636.v1
https://doi.org/10.1158/0008-5472.22412636.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Induction of gammaH2AX foci in HeLa cells, HeLa Rho minus cells and HeLa cells expressing mitochondrially targeted E. coli DNA ligase by L67. Panel B. N-acetyl cysteine inhibits L67-induced autophosphorylation of ATM in HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39918fd872f0fbbbb145a3742fe66984
https://doi.org/10.1158/0008-5472.22412642.v1
https://doi.org/10.1158/0008-5472.22412642.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Supplementary Materials and methods plus legends for six supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd3f40f9e9c9db55cfc5c47d0942df2
https://doi.org/10.1158/0008-5472.22412630.v1
https://doi.org/10.1158/0008-5472.22412630.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
Panel A. Characterization of HeLA cells expressing mitochondrially-targeted E. coli DNA ligase. DNA encoding the E. coli DNA detected by PCR and expression of GFP-tagged E. coli DNA ligase detected by immunoblotting. Panel B. Effect of L67 on DNA lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c6f8254fe81586581d6123cb1df7cf
https://doi.org/10.1158/0008-5472.22412648.v1
https://doi.org/10.1158/0008-5472.22412648.v1
Autor:
Alan E. Tomkinson, Bennett Van Houten, Vera Roginskaya, Yoshihiro Matsumoto, Annahita Sallmyr
L67 does not induce cleavage of caspases 7 or 9 in HeLa cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ac794028a874b7da0eb43d113fd7c4
https://doi.org/10.1158/0008-5472.22412633.v1
https://doi.org/10.1158/0008-5472.22412633.v1